(34 nodes) Ubiquitin-dependent ERAD pathway network (Pediculus humanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	E0W4B4_PEDHC	RDD domain-containing protein. (286 aa)
	E0W1I0_PEDHC	Ubiquitin-conjugating enzyme E2, putative. (204 aa)
	E0W1F4_PEDHC	Uncharacterized protein. (1831 aa)
	E0W0C3_PEDHC	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (264 aa)
	E0W030_PEDHC	Calnexin precursor, putative. (606 aa)
	E0VZR8_PEDHC	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (767 aa)
	E0VZR7_PEDHC	Ubiquitin-like domain-containing protein. (1267 aa)
	E0VZD5_PEDHC	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (525 aa)
	E0VYX2_PEDHC	Ssm4 protein, putative. (906 aa)
	E0VXH0_PEDHC	Ubiquitin-conjugating enzyme E2 G2, putative; Belongs to the ubiquitin-conjugating enzyme family. (169 aa)
	E0VXA0_PEDHC	Ancient ubiquitous protein, putative. (393 aa)
	E0VWT2_PEDHC	Heat shock 70 kDa protein cognate 3 precursor,putative; Belongs to the heat shock protein 70 family. (656 aa)
	E0VWS8_PEDHC	F-box only protein, putative. (271 aa)
	E0VWC3_PEDHC	Autocrine motility factor receptor, putative. (549 aa)
	E0VTU5_PEDHC	Ubiquitin conjugation factor E4 A, putative. (1082 aa)
	E0VSK4_PEDHC	Synoviolin, putative. (626 aa)
	E0VBI8_PEDHC	RING finger protein, putative. (325 aa)
	E0VAG3_PEDHC	FAS-associated factor, putative. (588 aa)
	E0V9N4_PEDHC	OTU domain-containing protein. (316 aa)
	E0V9I5_PEDHC	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (221 aa)
	E0VRW0_PEDHC	Uncharacterized protein. (135 aa)
	E0VQS0_PEDHC	Hsp90 protein, putative. (778 aa)
	E0VQJ1_PEDHC	Ubx domain-containing protein, putative. (228 aa)
	E0VQG9_PEDHC	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (634 aa)
	E0VQE6_PEDHC	UBX domain-containing protein, putative. (442 aa)
	E0VNV4_PEDHC	XTP3-transactivated gene B protein precursor,putative. (529 aa)
	E0VNJ7_PEDHC	Medulloblastoma antigen MU-MB-50.4, putative. (292 aa)
	E0VMM4_PEDHC	Ubiquitin fusion degradaton protein, putative. (316 aa)
	E0VLB7_PEDHC	J domain-containing protein. (321 aa)
	E0VKR5_PEDHC	Ubiquitin conjugation factor E4 B, putative. (1047 aa)
	E0VKQ4_PEDHC	Ubiquitin-conjugating enzyme E2 J1, putative. (246 aa)
	E0VK53_PEDHC	ANK_REP_REGION domain-containing protein. (582 aa)
	E0VG38_PEDHC	Small glutamine-rich tetratricopeptide repeat-containing protein A, putative. (303 aa)
	E0VFQ2_PEDHC	26S protease regulatory subunit S10B, putative; Belongs to the AAA ATPase family. (395 aa)

Your Current Organism:

Pediculus humanus

NCBI taxonomy Id: 121224
Other names: P. humanus corporis, Pediculus humanus corporis, Pediculus humanus humanus, human body lice, human body louse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E0V9I5_PEDHC	E0VAG3_PEDHC	E0V9I5	E0VAG3	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	FAS-associated factor, putative.	0.668
E0V9I5_PEDHC	E0VKQ4_PEDHC	E0V9I5	E0VKQ4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2 J1, putative.	0.547
E0V9I5_PEDHC	E0VMM4_PEDHC	E0V9I5	E0VMM4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Ubiquitin fusion degradaton protein, putative.	0.969
E0V9I5_PEDHC	E0VNV4_PEDHC	E0V9I5	E0VNV4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	XTP3-transactivated gene B protein precursor,putative.	0.993
E0V9I5_PEDHC	E0VQE6_PEDHC	E0V9I5	E0VQE6	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBX domain-containing protein, putative.	0.676
E0V9I5_PEDHC	E0VQG9_PEDHC	E0V9I5	E0VQG9	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.627
E0V9I5_PEDHC	E0VSK4_PEDHC	E0V9I5	E0VSK4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Synoviolin, putative.	0.941
E0V9I5_PEDHC	E0VWC3_PEDHC	E0V9I5	E0VWC3	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Autocrine motility factor receptor, putative.	0.941
E0V9I5_PEDHC	E0VWT2_PEDHC	E0V9I5	E0VWT2	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Heat shock 70 kDa protein cognate 3 precursor,putative; Belongs to the heat shock protein 70 family.	0.883
E0V9I5_PEDHC	E0VXA0_PEDHC	E0V9I5	E0VXA0	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Ancient ubiquitous protein, putative.	0.428
E0V9I5_PEDHC	E0VYX2_PEDHC	E0V9I5	E0VYX2	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Ssm4 protein, putative.	0.556
E0V9I5_PEDHC	E0W030_PEDHC	E0V9I5	E0W030	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Calnexin precursor, putative.	0.674
E0V9I5_PEDHC	E0W0C3_PEDHC	E0V9I5	E0W0C3	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.995
E0V9I5_PEDHC	E0W1I0_PEDHC	E0V9I5	E0W1I0	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2, putative.	0.604
E0V9N4_PEDHC	E0VKR5_PEDHC	E0V9N4	E0VKR5	OTU domain-containing protein.	Ubiquitin conjugation factor E4 B, putative.	0.890
E0V9N4_PEDHC	E0VMM4_PEDHC	E0V9N4	E0VMM4	OTU domain-containing protein.	Ubiquitin fusion degradaton protein, putative.	0.968
E0V9N4_PEDHC	E0VTU5_PEDHC	E0V9N4	E0VTU5	OTU domain-containing protein.	Ubiquitin conjugation factor E4 A, putative.	0.869
E0VAG3_PEDHC	E0V9I5_PEDHC	E0VAG3	E0V9I5	FAS-associated factor, putative.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.668
E0VAG3_PEDHC	E0VKR5_PEDHC	E0VAG3	E0VKR5	FAS-associated factor, putative.	Ubiquitin conjugation factor E4 B, putative.	0.575
E0VAG3_PEDHC	E0VMM4_PEDHC	E0VAG3	E0VMM4	FAS-associated factor, putative.	Ubiquitin fusion degradaton protein, putative.	0.964