node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
E0VEV6_PEDHC | E0VPE3_PEDHC | E0VEV6 | E0VPE3 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | ERCC4 domain-containing protein. | 0.794 |
E0VEV6_PEDHC | E0W3R6_PEDHC | E0VEV6 | E0W3R6 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Uncharacterized protein. | 0.709 |
E0VP82_PEDHC | E0VPE3_PEDHC | E0VP82 | E0VPE3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ERCC4 domain-containing protein. | 0.879 |
E0VP82_PEDHC | E0VRP4_PEDHC | E0VP82 | E0VRP4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Exonuclease, putative. | 0.905 |
E0VP82_PEDHC | E0VU37_PEDHC | E0VP82 | E0VU37 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA replication helicase DNA2, putative. | 0.950 |
E0VP82_PEDHC | E0VVF4_PEDHC | E0VP82 | E0VVF4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA excision repair protein, putative. | 0.557 |
E0VP82_PEDHC | E0W3R6_PEDHC | E0VP82 | E0W3R6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.716 |
E0VPE3_PEDHC | E0VEV6_PEDHC | E0VPE3 | E0VEV6 | ERCC4 domain-containing protein. | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | 0.794 |
E0VPE3_PEDHC | E0VP82_PEDHC | E0VPE3 | E0VP82 | ERCC4 domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.879 |
E0VPE3_PEDHC | E0VRP4_PEDHC | E0VPE3 | E0VRP4 | ERCC4 domain-containing protein. | Exonuclease, putative. | 0.904 |
E0VPE3_PEDHC | E0VU37_PEDHC | E0VPE3 | E0VU37 | ERCC4 domain-containing protein. | DNA replication helicase DNA2, putative. | 0.847 |
E0VPE3_PEDHC | E0VVF4_PEDHC | E0VPE3 | E0VVF4 | ERCC4 domain-containing protein. | DNA excision repair protein, putative. | 0.930 |
E0VPE3_PEDHC | E0W3R6_PEDHC | E0VPE3 | E0W3R6 | ERCC4 domain-containing protein. | Uncharacterized protein. | 0.836 |
E0VRP4_PEDHC | E0VP82_PEDHC | E0VRP4 | E0VP82 | Exonuclease, putative. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.905 |
E0VRP4_PEDHC | E0VPE3_PEDHC | E0VRP4 | E0VPE3 | Exonuclease, putative. | ERCC4 domain-containing protein. | 0.904 |
E0VRP4_PEDHC | E0VU37_PEDHC | E0VRP4 | E0VU37 | Exonuclease, putative. | DNA replication helicase DNA2, putative. | 0.961 |
E0VRP4_PEDHC | E0VVF4_PEDHC | E0VRP4 | E0VVF4 | Exonuclease, putative. | DNA excision repair protein, putative. | 0.495 |
E0VRP4_PEDHC | E0W3R6_PEDHC | E0VRP4 | E0W3R6 | Exonuclease, putative. | Uncharacterized protein. | 0.820 |
E0VU37_PEDHC | E0VP82_PEDHC | E0VU37 | E0VP82 | DNA replication helicase DNA2, putative. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.950 |
E0VU37_PEDHC | E0VPE3_PEDHC | E0VU37 | E0VPE3 | DNA replication helicase DNA2, putative. | ERCC4 domain-containing protein. | 0.847 |