(92 nodes) Winged helix DNA-binding domain superfamily network (Pediculus humanus)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	E0VYT3_PEDHC	Forkhead box protein D3, putative. (410 aa)
	E0VZ36_PEDHC	Rap guanine nucleotide exchange factor, putative. (899 aa)
	E0VZE3_PEDHC	Fli1, putative. (399 aa)
	E0VZG5_PEDHC	Forkhead box protein E1, putative. (462 aa)
	E0VZY2_PEDHC	ATP-dependent DNA helicase MER3, putative. (1018 aa)
	E0W056_PEDHC	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (315 aa)
	E0W062_PEDHC	Protein fork head, putative. (454 aa)
	E0W079_PEDHC	Cullin-1, putative; Belongs to the cullin family. (760 aa)
	E0W0J6_PEDHC	Regulator of G-protein signaling, putative. (790 aa)
	E0W0L5_PEDHC	26S proteasome non-ATPase regulatory subunit, putative. (414 aa)
	E0W150_PEDHC	40S ribosomal protein S19, putative. (144 aa)
	E0W1C1_PEDHC	DEP domain-containing protein. (860 aa)
	E0W1E0_PEDHC	Dishevelled, putative. (644 aa)
	E0W1E7_PEDHC	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (487 aa)
	E0W1T3_PEDHC	Lupus la ribonucleoprotein, putative. (549 aa)
	E0W1V2_PEDHC	26S proteasome non-ATPase regulatory subunit, putative. (384 aa)
	E0W291_PEDHC	Cullin-3, putative; Belongs to the cullin family. (607 aa)
	E0W2I2_PEDHC	COP9 signalosome complex subunit, putative. (439 aa)
	E0VI44_PEDHC	Transcription factor E2F3, putative. (292 aa)
	E0VHX5_PEDHC	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1786 aa)
	E0VHH9_PEDHC	Lupus la ribonucleoprotein, putative. (613 aa)
	E0VHF5_PEDHC	CULLIN_2 domain-containing protein; Belongs to the cullin family. (702 aa)
	E0VH79_PEDHC	Fork head domain-containing protein FD5, putative. (269 aa)
	E0VH78_PEDHC	Fork head domain-containing protein FD4, putative. (357 aa)
	E0VGT5_PEDHC	FYVE finger-containing phosphoinositide kinase, putative. (1864 aa)
	E0VGA6_PEDHC	Heat shock factor protein HSF30, putative. (732 aa)
	E0VFN6_PEDHC	26S proteasome regulatory subunit S3, putative. (505 aa)
	E0VN07_PEDHC	DNA-binding protein D-ETS-6, putative. (236 aa)
	E0VFI2_PEDHC	C-ets-2 protein, putative. (116 aa)
	E0VI92_PEDHC	Forkhead protein/ forkhead protein domain, putative. (130 aa)
	E0VI93_PEDHC	Forkhead protein/ forkhead protein domain, putative. (362 aa)
	E0VIT1_PEDHC	DNA replication factor Cdt1, putative. (655 aa)
	E0VJ00_PEDHC	Rfx4, putative. (498 aa)
	E0VJF8_PEDHC	Meiosis-specific transcription factor mei4, putative. (449 aa)
	E0VJJ9_PEDHC	Forkhead box protein I1, putative. (386 aa)
	E0VKE9_PEDHC	Histone H1-III-1, putative. (201 aa)
	E0VKP3_PEDHC	Serine/threonine-protein kinase RIO2, putative. (454 aa)
	E0VKS6_PEDHC	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (205 aa)
	E0VMG7_PEDHC	Blooms syndrome DNA helicase, putative. (1152 aa)
	E0VMN2_PEDHC	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (714 aa)
	E0VN35_PEDHC	Forkhead box protein N3, putative. (563 aa)
	E0VNS1_PEDHC	26S proteasome non-ATPase regulatory subunit, putative. (463 aa)
	E0VP80_PEDHC	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (272 aa)
	E0VPF6_PEDHC	Erm, putative. (260 aa)
	E0VPY1_PEDHC	Uncharacterized protein. (448 aa)
	E0VRA6_PEDHC	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (580 aa)
	E0VSK2_PEDHC	Protein C-ets-1-B, putative. (262 aa)
	E0VSQ7_PEDHC	COP9 signalosome complex subunit, putative. (427 aa)
	E0VSS5_PEDHC	Cullin-2, putative; Belongs to the cullin family. (702 aa)
	E0VT63_PEDHC	Anaphase-promoting complex subunit, putative; Belongs to the cullin family. (775 aa)
	E0VTF7_PEDHC	DEP domain-containing protein, putative. (1538 aa)
	E0VU52_PEDHC	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2199 aa)
	E0VV24_PEDHC	U520, putative. (2114 aa)
	E0VV64_PEDHC	Regulator of G-protein signaling, putative. (471 aa)
	E0VVJ7_PEDHC	Heat shock transcription factor, putative. (400 aa)
	E0VVK8_PEDHC	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (215 aa)
	E0VVX5_PEDHC	COP9 signalosome complex subunit, putative. (479 aa)
	E0VW05_PEDHC	COP9 signalosome complex subunit, putative. (408 aa)
	E0VW41_PEDHC	Fork head domain transcription factor slp1, putative. (402 aa)
	E0VW42_PEDHC	Hepatocyte nuclear factor 3-gamma, putative. (354 aa)
	E0VW52_PEDHC	Forkhead box protein C2, putative. (171 aa)
	E0VWI5_PEDHC	RNA polymerase-associated protein LEO1, putative. (972 aa)
	E0VWZ2_PEDHC	Activating signal cointegrator 1 complex subunit 3, helc1, putative. (2141 aa)
	E0VX24_PEDHC	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (563 aa)
	E0VXJ2_PEDHC	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (285 aa)
	E0VXR1_PEDHC	Uncharacterized protein. (620 aa)
	E0VXT3_PEDHC	YL1_C domain-containing protein. (396 aa)
	E0VDJ0_PEDHC	Transcription factor ETV6, putative. (511 aa)
	E0VD80_PEDHC	Cullin-5, putative; Belongs to the cullin family. (774 aa)
	E0VD54_PEDHC	Uncharacterized protein. (279 aa)
	E0VCN5_PEDHC	26S proteasome non-ATPase regulatory subunit, putative. (387 aa)
	E0VC93_PEDHC	Forkhead protein/ forkhead protein domain, putative. (520 aa)
	E0VC41_PEDHC	Uncharacterized protein. (229 aa)
	E0VBW6_PEDHC	La/SS-B, putative. (365 aa)
	E0VBI4_PEDHC	Epithelium specific ets factor 3, ese3, putative. (339 aa)
	E0VB42_PEDHC	Proliferation-associated protein 2G4, putative. (389 aa)
	E0VAZ9_PEDHC	Meiosis-specific transcription factor mei4, putative. (522 aa)
	E0VAX2_PEDHC	DNA-binding protein RFX2, putative. (744 aa)
	E0VAQ3_PEDHC	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (436 aa)
	E0VAD7_PEDHC	Rfx5, putative. (962 aa)
	E0V9P7_PEDHC	Uncharacterized protein. (441 aa)
	E0V958_PEDHC	Histone H1-II-1, putative. (224 aa)
	E0V936_PEDHC	Histone H1-II-1, putative. (212 aa)
	E0W2T5_PEDHC	Lupus la ribonucleoprotein, putative. (527 aa)
	E0W3D8_PEDHC	Forkhead protein/ forkhead protein domain, putative. (518 aa)
	E0W3L6_PEDHC	Uncharacterized protein. (1525 aa)
	E0W411_PEDHC	Cullin-4A, putative; Belongs to the cullin family. (733 aa)
	E0VDP4_PEDHC	Forkhead protein/ forkhead protein domain, putative. (716 aa)
	E0VE12_PEDHC	Cohesin subunit rad21, putative. (713 aa)
	E0VEM0_PEDHC	Transcription factor. (366 aa)
	E0VEU7_PEDHC	Vacuolar protein sorting protein, putative. (176 aa)
	E0VF80_PEDHC	DNA polymerase theta, putative. (1350 aa)

Your Current Organism:

Pediculus humanus

NCBI taxonomy Id: 121224
Other names: P. humanus corporis, Pediculus humanus corporis, Pediculus humanus humanus, human body lice, human body louse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E0VAQ3_PEDHC	E0VCN5_PEDHC	E0VAQ3	E0VCN5	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	26S proteasome non-ATPase regulatory subunit, putative.	0.527
E0VAQ3_PEDHC	E0VMN2_PEDHC	E0VAQ3	E0VMN2	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
E0VAQ3_PEDHC	E0VNS1_PEDHC	E0VAQ3	E0VNS1	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	26S proteasome non-ATPase regulatory subunit, putative.	0.817
E0VAQ3_PEDHC	E0VVK8_PEDHC	E0VAQ3	E0VVK8	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.984
E0VAQ3_PEDHC	E0VW05_PEDHC	E0VAQ3	E0VW05	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 signalosome complex subunit, putative.	0.506
E0VAQ3_PEDHC	E0W150_PEDHC	E0VAQ3	E0W150	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S19, putative.	0.960
E0VAX2_PEDHC	E0VC93_PEDHC	E0VAX2	E0VC93	DNA-binding protein RFX2, putative.	Forkhead protein/ forkhead protein domain, putative.	0.519
E0VAX2_PEDHC	E0VJJ9_PEDHC	E0VAX2	E0VJJ9	DNA-binding protein RFX2, putative.	Forkhead box protein I1, putative.	0.470
E0VAX2_PEDHC	E0VYT3_PEDHC	E0VAX2	E0VYT3	DNA-binding protein RFX2, putative.	Forkhead box protein D3, putative.	0.470
E0VB42_PEDHC	E0VKP3_PEDHC	E0VB42	E0VKP3	Proliferation-associated protein 2G4, putative.	Serine/threonine-protein kinase RIO2, putative.	0.551
E0VB42_PEDHC	E0VMN2_PEDHC	E0VB42	E0VMN2	Proliferation-associated protein 2G4, putative.	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.530
E0VB42_PEDHC	E0W150_PEDHC	E0VB42	E0W150	Proliferation-associated protein 2G4, putative.	40S ribosomal protein S19, putative.	0.848
E0VBW6_PEDHC	E0W1E7_PEDHC	E0VBW6	E0W1E7	La/SS-B, putative.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.666
E0VC41_PEDHC	E0VX24_PEDHC	E0VC41	E0VX24	Uncharacterized protein.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.998
E0VC41_PEDHC	E0VXJ2_PEDHC	E0VC41	E0VXJ2	Uncharacterized protein.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.992
E0VC93_PEDHC	E0VAX2_PEDHC	E0VC93	E0VAX2	Forkhead protein/ forkhead protein domain, putative.	DNA-binding protein RFX2, putative.	0.519
E0VCN5_PEDHC	E0VAQ3_PEDHC	E0VCN5	E0VAQ3	26S proteasome non-ATPase regulatory subunit, putative.	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.527
E0VCN5_PEDHC	E0VFN6_PEDHC	E0VCN5	E0VFN6	26S proteasome non-ATPase regulatory subunit, putative.	26S proteasome regulatory subunit S3, putative.	0.999
E0VCN5_PEDHC	E0VHF5_PEDHC	E0VCN5	E0VHF5	26S proteasome non-ATPase regulatory subunit, putative.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.460
E0VCN5_PEDHC	E0VNS1_PEDHC	E0VCN5	E0VNS1	26S proteasome non-ATPase regulatory subunit, putative.	26S proteasome non-ATPase regulatory subunit, putative.	0.999