(33 nodes) SH2 domain superfamily network (Pediculus humanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	E0W242_PEDHC	Cytoplasmic protein NCK1, putative. (424 aa)
	E0V9R3_PEDHC	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1274 aa)
	E0VB13_PEDHC	Tyrosine-protein kinase. (402 aa)
	E0VD29_PEDHC	N-chimaerin, putative. (451 aa)
	E0VDI2_PEDHC	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1783 aa)
	E0VDK7_PEDHC	Tyrosine-protein kinase. (644 aa)
	E0VE57_PEDHC	Sh2 domain containing protein, putative. (253 aa)
	E0VF33_PEDHC	Tens, putative. (1186 aa)
	E0VFQ9_PEDHC	Suppressors of cytokine signaling-5, putative. (526 aa)
	E0VH77_PEDHC	Tyrosine-protein kinase. (1108 aa)
	E0VHG6_PEDHC	Suppressor of cytokine signaling-2, putative. (613 aa)
	E0VIR8_PEDHC	Signal transduction protein lnk-related, putative. (504 aa)
	E0VJF3_PEDHC	Ras GTPase-activating protein, putative. (874 aa)
	E0VJN3_PEDHC	Uncharacterized protein. (792 aa)
	E0VKB1_PEDHC	Tyrosine-protein kinase. (850 aa)
	E0VLH8_PEDHC	RAB GDP/GTP exchange factor, putative. (1381 aa)
	E0VM96_PEDHC	Tyrosine-protein kinase. (493 aa)
	E0VNA4_PEDHC	Adapter molecule Crk, putative. (263 aa)
	E0VNH9_PEDHC	Signal transducer and activator of transcription. (791 aa)
	E0VQI9_PEDHC	Tyrosine-protein kinase. (466 aa)
	E0VQV3_PEDHC	Shc transforming protein, putative. (419 aa)
	E0VR81_PEDHC	E3 ubiquitin-protein ligase CBL, putative. (455 aa)
	E0VSD3_PEDHC	SH2 domain-containing protein. (1195 aa)
	E0VST4_PEDHC	Protein E, putative. (211 aa)
	E0VV62_PEDHC	Protein vav, putative. (732 aa)
	E0VX42_PEDHC	SH2 domain-containing protein 4A, putative. (472 aa)
	E0VXC8_PEDHC	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (622 aa)
	E0VXG9_PEDHC	Uncharacterized protein. (653 aa)
	E0VXU2_PEDHC	Growth factor receptor-bound protein, putative. (494 aa)
	E0VXY7_PEDHC	Tyrosine-protein kinase. (751 aa)
	E0VYA2_PEDHC	Phosphatidylinositol 3-kinase regulatory subunit alpha, putative. (726 aa)
	E0VZT3_PEDHC	Tyrosine-protein kinase. (1347 aa)
	E0W1K0_PEDHC	SH2 domain-containing protein. (378 aa)

Your Current Organism:

Pediculus humanus

NCBI taxonomy Id: 121224
Other names: P. humanus corporis, Pediculus humanus corporis, Pediculus humanus humanus, human body lice, human body louse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E0V9R3_PEDHC	E0VB13_PEDHC	E0V9R3	E0VB13	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.611
E0V9R3_PEDHC	E0VDK7_PEDHC	E0V9R3	E0VDK7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.453
E0V9R3_PEDHC	E0VE57_PEDHC	E0V9R3	E0VE57	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Sh2 domain containing protein, putative.	0.744
E0V9R3_PEDHC	E0VM96_PEDHC	E0V9R3	E0VM96	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.453
E0V9R3_PEDHC	E0VQI9_PEDHC	E0V9R3	E0VQI9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.453
E0V9R3_PEDHC	E0VQV3_PEDHC	E0V9R3	E0VQV3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Shc transforming protein, putative.	0.836
E0V9R3_PEDHC	E0VR81_PEDHC	E0V9R3	E0VR81	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	E3 ubiquitin-protein ligase CBL, putative.	0.471
E0V9R3_PEDHC	E0VST4_PEDHC	E0V9R3	E0VST4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Protein E, putative.	0.937
E0V9R3_PEDHC	E0VV62_PEDHC	E0V9R3	E0VV62	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Protein vav, putative.	0.790
E0V9R3_PEDHC	E0VXC8_PEDHC	E0V9R3	E0VXC8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.450
E0V9R3_PEDHC	E0VYA2_PEDHC	E0V9R3	E0VYA2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol 3-kinase regulatory subunit alpha, putative.	0.935
E0V9R3_PEDHC	E0W242_PEDHC	E0V9R3	E0W242	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Cytoplasmic protein NCK1, putative.	0.546
E0VB13_PEDHC	E0V9R3_PEDHC	E0VB13	E0V9R3	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.611
E0VB13_PEDHC	E0VDK7_PEDHC	E0VB13	E0VDK7	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.439
E0VB13_PEDHC	E0VE57_PEDHC	E0VB13	E0VE57	Tyrosine-protein kinase.	Sh2 domain containing protein, putative.	0.460
E0VB13_PEDHC	E0VH77_PEDHC	E0VB13	E0VH77	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.465
E0VB13_PEDHC	E0VIR8_PEDHC	E0VB13	E0VIR8	Tyrosine-protein kinase.	Signal transduction protein lnk-related, putative.	0.416
E0VB13_PEDHC	E0VKB1_PEDHC	E0VB13	E0VKB1	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.528
E0VB13_PEDHC	E0VM96_PEDHC	E0VB13	E0VM96	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.883
E0VB13_PEDHC	E0VNA4_PEDHC	E0VB13	E0VNA4	Tyrosine-protein kinase.	Adapter molecule Crk, putative.	0.604