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gltB3 gltB3 dapA dapA lysA1 lysA1 BN159_0086 BN159_0086 BN159_0043 BN159_0043 dapE dapE BN159_5215 BN159_5215 hutU hutU BN159_5213 BN159_5213 BN159_5206 BN159_5206 ppc ppc aroH1 aroH1 BN159_4353 BN159_4353 BN159_4326 BN159_4326 BN159_4325 BN159_4325 kynU kynU ask ask asd1 asd1 BN159_4095 BN159_4095 BN159_4069 BN159_4069 folK folK folB folB folP1 folP1 nadB nadB hemA hemA BN159_3946 BN159_3946 BN159_3634 BN159_3634 glyA5 glyA5 BN159_3512 BN159_3512 hutH hutH fumC fumC glsA glsA aspA aspA BN159_7845 BN159_7845 aroB aroB aroK aroK aroC aroC BN159_7090 BN159_7090 BN159_7045 BN159_7045 BN159_6844 BN159_6844 BN159_6786 BN159_6786 BN159_6657 BN159_6657 BN159_6611 BN159_6611 BN159_6606 BN159_6606 dapA2 dapA2 dapD dapD aroQ aroQ BN159_6499 BN159_6499 BN159_6445 BN159_6445 gltB1 gltB1 BN159_6411 BN159_6411 aroH3 aroH3 nadA nadA BN159_5781 BN159_5781 gudD gudD BN159_5754 BN159_5754 asd3 asd3 BN159_5542 BN159_5542 aroA aroA BN159_5336 BN159_5336 gdhB gdhB hutI hutI BN159_3203 BN159_3203 aroA2 aroA2 BN159_3104 BN159_3104 lysA3 lysA3 glyA3 glyA3 glyA1 glyA1 BN159_2884 BN159_2884 dapB dapB dapA1 dapA1 dapF dapF BN159_2333 BN159_2333 frc frc aroE aroE BN159_1762 BN159_1762 BN159_1692 BN159_1692
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gltB3Glutamate synthase [NADPH] small chain. (487 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (329 aa)
lysA1Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (443 aa)
BN159_0086Hypothetical protein. (341 aa)
BN159_0043Peptidase dimerization domain-containing protein. (425 aa)
dapESuccinyl-diaminopimelate desuccinylase. (359 aa)
BN159_5215Allantoate amidohydrolase. (415 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (554 aa)
BN159_5213Diaminopimelate decarboxylase. (470 aa)
BN159_5206Phenylalanine and histidine ammonia-lyase. (502 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (913 aa)
aroH1Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (462 aa)
BN159_4353Peptidase M20D. (397 aa)
BN159_4326Integral membrane protein. (437 aa)
BN159_4325Hypothetical protein. (358 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (395 aa)
askAspartokinase; Belongs to the aspartokinase family. (425 aa)
asd1Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (352 aa)
BN159_4095Hypothetical protein. (481 aa)
BN159_4069Glutamate decarboxylase; Belongs to the group II decarboxylase family. (464 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. (203 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
folP1Dihydropteroate synthase 1. (287 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (570 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (565 aa)
BN159_3946Peptidase dimerization domain-containing protein. (420 aa)
BN159_3634Hypothetical protein. (100 aa)
glyA5Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (482 aa)
BN159_3512Carboxylate-amine ligase. (407 aa)
hutHHistidine ammonia-lyase. (544 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
glsAGlutaminase; Belongs to the glutaminase family. (313 aa)
aspAAspartate ammonia-lyase. (469 aa)
BN159_7845M20/M25/M40 family peptidase. (451 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
BN159_7090Shikimate-5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (279 aa)
BN159_7045Regulator. (137 aa)
BN159_6844Dehydratase; Belongs to the CoA-transferase III family. (402 aa)
BN159_6786Chorismate mutase. (120 aa)
BN159_6657Hypothetical protein. (363 aa)
BN159_66115-dehydro-4-deoxyglucarate dehydratase; Belongs to the DapA family. (303 aa)
BN159_6606Putative 5-dehydro-4-deoxyglucarate dehydratase 1; Belongs to the DapA family. (314 aa)
dapA2Dihydrodipicolinate synthase 2; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa)
dapDTransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (329 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa)
BN159_6499Glutamate synthase 1 [NADH]. (495 aa)
BN159_6445Chorismate mutase. (116 aa)
gltB1Ferredoxin-dependent glutamate synthase 1. (1530 aa)
BN159_6411formyl-CoA transferase; Belongs to the CoA-transferase III family. (411 aa)
aroH3Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (450 aa)
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
BN159_5781Dihydrodipicolinate synthase; Belongs to the DapA family. (308 aa)
gudDPutative glucarate dehydratase; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (429 aa)
BN159_5754Putative 5-dehydro-4-deoxyglucarate dehydratase 2; Belongs to the DapA family. (307 aa)
asd3Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa)
BN159_5542Hypothetical protein. (383 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (410 aa)
BN159_5336NAD-dependent malic enzyme. (477 aa)
gdhBNAD-specific glutamate dehydrogenase. (1644 aa)
hutIImidazolonepropionase. (402 aa)
BN159_3203Peptidase. (470 aa)
aroA23-phosphoshikimate 1-carboxyvinyltransferase 2; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (438 aa)
BN159_3104NAD-dependent malic enzyme. (407 aa)
lysA3Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
glyA3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
glyA1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
BN159_2884Proline dehydrogenase. (308 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa)
dapA1Dihydrodipicolinate synthase 1; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa)
BN159_2333Lysine/ornithine decarboxylase. (392 aa)
frcFormyl-coenzyme A transferase; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate; Belongs to the CoA-transferase III family. Frc subfamily. (413 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa)
BN159_1762Dihydrodipicolinate synthase; Belongs to the DapA family. (298 aa)
BN159_1692Alpha-methylacyl-CoA racemase; Belongs to the CoA-transferase III family. (377 aa)
Your Current Organism:
Streptomyces davaonensis
NCBI taxonomy Id: 1214101
Other names: S. davaonensis JCM 4913, Streptomyces davaonensis 768, Streptomyces davaonensis JCM 4913, Streptomyces davawensis 768, Streptomyces davawensis JCM 4913
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