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egtB egtB egtC egtC egtD egtD BN159_1507 BN159_1507 hisN hisN hutH hutH dhaS dhaS yfmT yfmT pat pat BN159_5206 BN159_5206 hutU hutU hutI hutI BN159_6072 BN159_6072 hisD hisD hisC hisC hisB hisB hisH hisH priA1 priA1 hisF hisF hisI hisI BN159_6660 BN159_6660 BN159_6862 BN159_6862 hisE hisE hisG hisG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
egtBSulfatase modifying factor; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (434 aa)
egtCHypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (263 aa)
egtDs-adenosyl-L-methionine- dependentmethyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (320 aa)
BN159_1507Hypothetical protein. (260 aa)
hisNHistidinol-phosphatase. (266 aa)
hutHHistidine ammonia-lyase. (544 aa)
dhaSPutative aldehyde dehydrogenase dhaS. (476 aa)
yfmTPutative aldehyde dehydrogenase yfmT; Belongs to the aldehyde dehydrogenase family. (486 aa)
patPutative phenylalanine aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
BN159_5206Phenylalanine and histidine ammonia-lyase. (502 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (554 aa)
hutIImidazolonepropionase. (402 aa)
BN159_6072Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa)
hisBImidazoleglycerol-phosphate dehydratase. (197 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (214 aa)
priA1Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (242 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (129 aa)
BN159_6660Putative aminotransferase. (372 aa)
BN159_6862Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (461 aa)
hisEHypothetical protein. (90 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
Your Current Organism:
Streptomyces davaonensis
NCBI taxonomy Id: 1214101
Other names: S. davaonensis JCM 4913, Streptomyces davaonensis 768, Streptomyces davaonensis JCM 4913, Streptomyces davawensis 768, Streptomyces davawensis JCM 4913
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