(40 nodes) Histidine kinase, and Transcription regulator LuxR, C-terminal network (Streptomyces collinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AGS66985.1	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (208 aa)
	AGS67270.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (219 aa)
	AGS67271.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (467 aa)
	AGS67923.1	Two component system response regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (221 aa)
	AGS67924.1	Two component system sensor kinase; COG4585 Signal transduction histidine kinase. (404 aa)
	AGS68106.1	Putative two-component system response regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (234 aa)
	AGS68107.1	Putative two-component sensor kinase; COG4585 Signal transduction histidine kinase. (393 aa)
	AGS68143.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (383 aa)
	AGS68144.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (217 aa)
	AGS68688.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (213 aa)
	AGS68689.1	Two-component system sensor kinase; COG2203 FOG: GAF domain. (381 aa)
	AGS69088.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (226 aa)
	AGS69089.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (406 aa)
	AGS69238.1	Two-component sensor kinase; COG4585 Signal transduction histidine kinase. (426 aa)
	AGS69240.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (203 aa)
	AGS69475.1	Putative two-component system response regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (193 aa)
	AGS69476.1	COG4585 Signal transduction histidine kinase. (789 aa)
	AGS70069.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (255 aa)
	AGS70077.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (228 aa)
	AGS70494.1	ABC transporter ATP-binding protein; COG1131 ABC-type multidrug transport system, ATPase component. (313 aa)
	AGS70495.1	ABC transporter permease; COG0842 ABC-type multidrug transport system, permease component. (259 aa)
	AGS70496.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (421 aa)
	AGS70497.1	Two component system response regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (204 aa)
	AGS70965.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (401 aa)
	AGS70966.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (223 aa)
	AGS71143.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (219 aa)
	AGS71144.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (454 aa)
	AGS71145.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (395 aa)
	AGS71286.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (203 aa)
	AGS71312.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (242 aa)
	AGS71506.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (446 aa)
	AGS71507.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (269 aa)
	AGS71632.1	ABC transporter ATP-binding protein; COG1131 ABC-type multidrug transport system, ATPase component. (309 aa)
	AGS71633.1	COG0842 ABC-type multidrug transport system, permease component. (246 aa)
	AGS71634.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (397 aa)
	AGS71635.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (201 aa)
	AGS72462.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (219 aa)
	AGS73424.1	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase. (467 aa)
	AGS73425.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (219 aa)
	AGS73709.1	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (208 aa)

Your Current Organism:

Streptomyces collinus

NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGS66985.1	AGS67271.1	B446_00735	B446_02195	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.813
AGS66985.1	AGS67924.1	B446_00735	B446_05490	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.817
AGS66985.1	AGS68107.1	B446_00735	B446_06415	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Putative two-component sensor kinase; COG4585 Signal transduction histidine kinase.	0.810
AGS66985.1	AGS68143.1	B446_00735	B446_06595	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.734
AGS66985.1	AGS68689.1	B446_00735	B446_09330	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG2203 FOG: GAF domain.	0.816
AGS66985.1	AGS69089.1	B446_00735	B446_11335	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.807
AGS66985.1	AGS69238.1	B446_00735	B446_12080	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component sensor kinase; COG4585 Signal transduction histidine kinase.	0.782
AGS66985.1	AGS69476.1	B446_00735	B446_13290	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG4585 Signal transduction histidine kinase.	0.674
AGS66985.1	AGS70069.1	B446_00735	B446_16255	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.774
AGS66985.1	AGS70077.1	B446_00735	B446_16295	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.774
AGS66985.1	AGS70496.1	B446_00735	B446_18400	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.717
AGS66985.1	AGS70965.1	B446_00735	B446_20765	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.799
AGS66985.1	AGS71143.1	B446_00735	B446_21655	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.759
AGS66985.1	AGS71144.1	B446_00735	B446_21660	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.669
AGS66985.1	AGS71145.1	B446_00735	B446_21665	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.621
AGS66985.1	AGS71506.1	B446_00735	B446_23470	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.799
AGS66985.1	AGS71507.1	B446_00735	B446_23475	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.773
AGS66985.1	AGS71634.1	B446_00735	B446_24115	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.664
AGS66985.1	AGS73424.1	B446_00735	B446_33100	LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.813
AGS67270.1	AGS67271.1	B446_02190	B446_02195	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two-component system sensor kinase; COG4585 Signal transduction histidine kinase.	0.960