STRINGSTRING
AGS66927.1 AGS66927.1 AGS67012.1 AGS67012.1 AGS67027.1 AGS67027.1 AGS67144.1 AGS67144.1 AGS67217.1 AGS67217.1 AGS67580.1 AGS67580.1 AGS67604.1 AGS67604.1 AGS67698.1 AGS67698.1 AGS67754.1 AGS67754.1 AGS67794.1 AGS67794.1 aspA aspA AGS67868.1 AGS67868.1 AGS67907.1 AGS67907.1 AGS67915.1 AGS67915.1 AGS67944.1 AGS67944.1 gabD1 gabD1 AGS68156.1 AGS68156.1 gcvP gcvP AGS68344.1 AGS68344.1 metK metK AGS68416.1 AGS68416.1 AGS68535.1 AGS68535.1 AGS68695.1 AGS68695.1 AGS68777.1 AGS68777.1 AGS68832.1 AGS68832.1 tal tal pgi1 pgi1 tpiA tpiA pgk pgk AGS68850.1 AGS68850.1 AGS68922.1 AGS68922.1 AGS69030.1 AGS69030.1 pfp pfp AGS69107.1 AGS69107.1 AGS69108.1 AGS69108.1 AGS69110.1 AGS69110.1 lipB lipB lipA lipA aceE aceE AGS69380.1 AGS69380.1 leuA leuA AGS69602.1 AGS69602.1 AGS69675.1 AGS69675.1 gltA gltA AGS69738.1 AGS69738.1 AGS69788.1 AGS69788.1 AGS69789.1 AGS69789.1 AGS69790.1 AGS69790.1 AGS69791.1 AGS69791.1 AGS69896.1 AGS69896.1 ahcY ahcY AGS70018.1 AGS70018.1 eno eno prs prs ppc ppc purU purU AGS70251.1 AGS70251.1 serC serC AGS70315.1 AGS70315.1 AGS70605.1 AGS70605.1 AGS70695.1 AGS70695.1 AGS70696.1 AGS70696.1 AGS70697.1 AGS70697.1 AGS70707.1 AGS70707.1 AGS70708.1 AGS70708.1 AGS70709.1 AGS70709.1 AGS70779.1 AGS70779.1 AGS70780.1 AGS70780.1 AGS70815.1 AGS70815.1 acsA acsA ilvD ilvD AGS71054.1 AGS71054.1 AGS71141.1 AGS71141.1 AGS71142.1 AGS71142.1 AGS71201.1 AGS71201.1 gabD2 gabD2 sucC sucC sucD sucD folD folD mdh mdh glyA-2 glyA-2 sdhB sdhB sdhA1 sdhA1 AGS71369.1 AGS71369.1 AGS71370.1 AGS71370.1 AGS71427.1 AGS71427.1 AGS71454.1 AGS71454.1 AGS71458.1 AGS71458.1 pckG pckG AGS71478.1 AGS71478.1 fumC fumC AGS71534.1 AGS71534.1 glpX glpX AGS71544.1 AGS71544.1 AGS71600.1 AGS71600.1 sdhA2 sdhA2 AGS71768.1 AGS71768.1 kgd kgd AGS71830.1 AGS71830.1 AGS71831.1 AGS71831.1 thrB thrB glyA-3 glyA-3 AGS71893.1 AGS71893.1 pfkA-2 pfkA-2 AGS71934.1 AGS71934.1 glyA glyA gcvH gcvH gcvT gcvT AGS71962.1 AGS71962.1 AGS71979.1 AGS71979.1 ilvH ilvH ilvC ilvC AGS71982.1 AGS71982.1 leuB leuB AGS71991.1 AGS71991.1 AGS71997.1 AGS71997.1 leuC leuC leuD leuD AGS72272.1 AGS72272.1 AGS72273.1 AGS72273.1 AGS72319.1 AGS72319.1 AGS72326.1 AGS72326.1 AGS72442.1 AGS72442.1 AGS72467.1 AGS72467.1 mmuM mmuM AGS72648.1 AGS72648.1 AGS72660.1 AGS72660.1 AGS72710.1 AGS72710.1 AGS72726.1 AGS72726.1 AGS72738.1 AGS72738.1 AGS72785.1 AGS72785.1 pgi2 pgi2 zwf-2 zwf-2 tal-2 tal-2 AGS72891.1 AGS72891.1 tdh tdh kbl kbl AGS73059.1 AGS73059.1 AGS73090.1 AGS73090.1 AGS73100.1 AGS73100.1 AGS73121.1 AGS73121.1 AGS73192.1 AGS73192.1 sdhA3 sdhA3 AGS73194.1 AGS73194.1 AGS73291.1 AGS73291.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
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gene neighborhood
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gene co-occurrence
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AGS66927.1Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (473 aa)
AGS67012.1Hypothetical protein; COG0367 Asparagine synthase (glutamine-hydrolyzing). (592 aa)
AGS67027.1Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (434 aa)
AGS67144.1COG0031 Cysteine synthase. (757 aa)
AGS67217.1Hypothetical protein; COG0499 S-adenosylhomocysteine hydrolase. (560 aa)
AGS67580.1COG0033 Phosphoglucomutase. (546 aa)
AGS67604.1COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (464 aa)
AGS67698.1COG1171 Threonine dehydratase. (322 aa)
AGS67754.1COG0367 Asparagine synthase (glutamine-hydrolyzing). (613 aa)
AGS67794.1COG0698 Ribose 5-phosphate isomerase RpiB. (159 aa)
aspACOG1027 Aspartate ammonia-lyase. (469 aa)
AGS67868.1COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
AGS67907.1Cysteine synthase/cystathionine beta-synthase family protein; COG0031 Cysteine synthase. (374 aa)
AGS67915.1COG0191 Fructose/tagatose bisphosphate aldolase. (292 aa)
AGS67944.1Aldolase; COG2008 Threonine aldolase. (356 aa)
gabD1Succinic semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases. (461 aa)
AGS68156.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (399 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
AGS68344.1COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
AGS68416.1Aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (273 aa)
AGS68535.15-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1156 aa)
AGS68695.13-phosphoserine phosphatase; COG3830 ACT domain-containing protein. (402 aa)
AGS68777.1COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (580 aa)
AGS68832.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (695 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
pgi1COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. (550 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
AGS68850.1COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
AGS68922.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
AGS69030.1COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
AGS69107.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
AGS69108.1Dihydrolipoyllysine-residue succinyltransferase; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (597 aa)
AGS69110.12-oxoacid dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
lipBLipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (262 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
aceEPyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (878 aa)
AGS69380.1Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (906 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
AGS69602.1COG0698 Ribose 5-phosphate isomerase RpiB. (162 aa)
AGS69675.1COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (429 aa)
AGS69738.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (539 aa)
AGS69788.1LuxAB-like protein (oxygenase); COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. (362 aa)
AGS69789.1Decarboxylase; COG3473 Maleate cis-trans isomerase. (243 aa)
AGS69790.1Decarboxylase; COG3473 Maleate cis-trans isomerase. (285 aa)
AGS69791.1NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases. (317 aa)
AGS69896.1Malate oxidoreductase; COG0281 Malic enzyme. (471 aa)
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (485 aa)
AGS70018.1Cystathionine beta-synthase; COG0031 Cysteine synthase. (463 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (438 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (910 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
AGS70251.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (366 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
AGS70315.1COG0498 Threonine synthase. (392 aa)
AGS70605.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (382 aa)
AGS70695.1COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (381 aa)
AGS70696.1COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (334 aa)
AGS70697.1Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (444 aa)
AGS70707.1COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (401 aa)
AGS70708.1COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (328 aa)
AGS70709.1Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (475 aa)
AGS70779.1COG3958 Transketolase, C-terminal subunit. (316 aa)
AGS70780.1COG3959 Transketolase, N-terminal subunit. (272 aa)
AGS70815.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
ilvDCOG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (617 aa)
AGS71054.1Glucose 1-dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (285 aa)
AGS71141.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (353 aa)
AGS71142.1COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (642 aa)
AGS71201.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (408 aa)
gabD2Succinic semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (537 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (483 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
sdhA1COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (584 aa)
AGS71369.1COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. (160 aa)
AGS71370.1COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (126 aa)
AGS71427.1Flavoprotein disulfide reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (482 aa)
AGS71454.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (384 aa)
AGS71458.1COG1171 Threonine dehydratase. (409 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
AGS71478.1Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (403 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
AGS71534.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (554 aa)
glpXCOG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins. (344 aa)
AGS71544.1Polyphosphate glucokinase; COG1940 Transcriptional regulator/sugar kinase. (250 aa)
AGS71600.1COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (256 aa)
sdhA2COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (643 aa)
AGS71768.1Malate oxidoreductase; COG0281 Malic enzyme. (406 aa)
kgdAlpha-ketoglutarate decarboxylase; COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (1268 aa)
AGS71830.1COG0460 Homoserine dehydrogenase. (429 aa)
AGS71831.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
AGS71893.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (475 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AGS71934.1COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
AGS71962.1Hypothetical protein. (333 aa)
AGS71979.1Acetolactate synthase 1 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (616 aa)
ilvHCOG0440 Acetolactate synthase, small (regulatory) subunit. (174 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
AGS71982.1COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
AGS71991.1COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (362 aa)
AGS71997.1Alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
AGS72272.1COG0372 Citrate synthase. (423 aa)
AGS72273.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (388 aa)
AGS72319.1NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (280 aa)
AGS72326.1Asparaginase/glutaminase; COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D. (333 aa)
AGS72442.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AGS72467.1Flavoprotein oxidoreductase; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. (479 aa)
mmuMCOG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent). (311 aa)
AGS72648.1Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (402 aa)
AGS72660.1COG2225 Malate synthase; Belongs to the malate synthase family. (541 aa)
AGS72710.1COG0095 Lipoate-protein ligase A. (354 aa)
AGS72726.1COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa)
AGS72738.1COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
AGS72785.1COG0021 Transketolase. (615 aa)
pgi2COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. (554 aa)
zwf-2Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (531 aa)
tal-2Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (377 aa)
AGS72891.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (691 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (399 aa)
AGS73059.1COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
AGS73090.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (591 aa)
AGS73100.1COG2008 Threonine aldolase. (399 aa)
AGS73121.1COG1012 NAD-dependent aldehyde dehydrogenases. (415 aa)
AGS73192.1Cytochrome b subunit; COG0642 Signal transduction histidine kinase. (223 aa)
sdhA3COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (649 aa)
AGS73194.1COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (249 aa)
AGS73291.1Ribose-phosphate pyrophosphokinase; COG0462 Phosphoribosylpyrophosphate synthetase. (317 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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