STRINGSTRING
gabD1 gabD1 AGS69107.1 AGS69107.1 AGS69108.1 AGS69108.1 AGS69110.1 AGS69110.1 lipB lipB lipA lipA aceE aceE gltA gltA AGS69896.1 AGS69896.1 AGS70251.1 AGS70251.1 AGS70695.1 AGS70695.1 AGS70696.1 AGS70696.1 AGS70697.1 AGS70697.1 AGS70707.1 AGS70707.1 AGS70708.1 AGS70708.1 AGS70709.1 AGS70709.1 acsA acsA AGS71141.1 AGS71141.1 AGS71142.1 AGS71142.1 gabD2 gabD2 sucC sucC sucD sucD mdh mdh sdhB sdhB sdhA1 sdhA1 AGS71369.1 AGS71369.1 AGS71370.1 AGS71370.1 AGS71427.1 AGS71427.1 fumC fumC AGS71534.1 AGS71534.1 AGS71600.1 AGS71600.1 sdhA2 sdhA2 AGS71768.1 AGS71768.1 kgd kgd AGS72272.1 AGS72272.1 AGS72273.1 AGS72273.1 AGS72442.1 AGS72442.1 AGS72467.1 AGS72467.1 AGS72660.1 AGS72660.1 AGS72710.1 AGS72710.1 AGS73059.1 AGS73059.1 AGS73121.1 AGS73121.1 AGS73192.1 AGS73192.1 sdhA3 sdhA3 AGS73194.1 AGS73194.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gabD1Succinic semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases. (461 aa)
AGS69107.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
AGS69108.1Dihydrolipoyllysine-residue succinyltransferase; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (597 aa)
AGS69110.12-oxoacid dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
lipBLipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (262 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
aceEPyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (878 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (429 aa)
AGS69896.1Malate oxidoreductase; COG0281 Malic enzyme. (471 aa)
AGS70251.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (366 aa)
AGS70695.1COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (381 aa)
AGS70696.1COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (334 aa)
AGS70697.1Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (444 aa)
AGS70707.1COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (401 aa)
AGS70708.1COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (328 aa)
AGS70709.1Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (475 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AGS71141.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (353 aa)
AGS71142.1COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (642 aa)
gabD2Succinic semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (537 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
sdhA1COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (584 aa)
AGS71369.1COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. (160 aa)
AGS71370.1COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (126 aa)
AGS71427.1Flavoprotein disulfide reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (482 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
AGS71534.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (554 aa)
AGS71600.1COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (256 aa)
sdhA2COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (643 aa)
AGS71768.1Malate oxidoreductase; COG0281 Malic enzyme. (406 aa)
kgdAlpha-ketoglutarate decarboxylase; COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (1268 aa)
AGS72272.1COG0372 Citrate synthase. (423 aa)
AGS72273.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (388 aa)
AGS72442.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AGS72467.1Flavoprotein oxidoreductase; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. (479 aa)
AGS72660.1COG2225 Malate synthase; Belongs to the malate synthase family. (541 aa)
AGS72710.1COG0095 Lipoate-protein ligase A. (354 aa)
AGS73059.1COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
AGS73121.1COG1012 NAD-dependent aldehyde dehydrogenases. (415 aa)
AGS73192.1Cytochrome b subunit; COG0642 Signal transduction histidine kinase. (223 aa)
sdhA3COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (649 aa)
AGS73194.1COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (249 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.