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AGS67145.1 AGS67145.1 AGS67616.1 AGS67616.1 hemC-2 hemC-2 AGS68423.1 AGS68423.1 cobT-2 cobT-2 AGS68425.1 AGS68425.1 cobD cobD cobQ cobQ cobN cobN AGS68746.1 AGS68746.1 AGS68747.1 AGS68747.1 cobB cobB AGS68749.1 AGS68749.1 AGS68751.1 AGS68751.1 AGS68752.1 AGS68752.1 AGS68753.1 AGS68753.1 AGS68754.1 AGS68754.1 AGS68755.1 AGS68755.1 AGS69095.1 AGS69095.1 cobT cobT cobS cobS AGS69902.1 AGS69902.1 hemA hemA hemC hemC AGS71022.1 AGS71022.1 AGS71024.1 AGS71024.1 hemL hemL AGS71858.1 AGS71858.1 hemH hemH hemE hemE AGS72468.1 AGS72468.1 AGS72469.1 AGS72469.1 AGS73016.1 AGS73016.1 AGS73017.1 AGS73017.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AGS67145.1GHMP kinase; COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase. (327 aa)
AGS67616.1Aminotransferase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
hemC-2Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (311 aa)
AGS68423.1uroporphyrin-III methyltransferase; COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); Belongs to the precorrin methyltransferase family. (409 aa)
cobT-2Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1417 aa)
AGS68425.1precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. (408 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (314 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
cobNCobaltochelatase subunit CobN; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. (1210 aa)
AGS68746.1COG1239 Mg-chelatase subunit ChlI. (670 aa)
AGS68747.1cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; COG2109 ATP:corrinoid adenosyltransferase. (199 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa)
AGS68749.1COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. (247 aa)
AGS68751.1COG2875 Precorrin-4 methylase. (272 aa)
AGS68752.1precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. (413 aa)
AGS68753.1Precorrin methylase; COG2073 Cobalamin biosynthesis protein CbiG. (566 aa)
AGS68754.1precorrin-8X methylmutase; COG2082 Precorrin isomerase. (195 aa)
AGS68755.1Metal binding protein. (303 aa)
AGS69095.1COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase. (400 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (378 aa)
cobSCobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (261 aa)
AGS69902.1Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; COG1587 Uroporphyrinogen-III synthase. (387 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (566 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (303 aa)
AGS71022.1uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; COG0007 Uroporphyrinogen-III methylase. (569 aa)
AGS71024.1COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (310 aa)
hemLCOG0001 Glutamate-1-semialdehyde aminotransferase. (439 aa)
AGS71858.1Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (375 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa)
AGS72468.1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (472 aa)
AGS72469.1Hypothetical protein. (243 aa)
AGS73016.1COG2099 Precorrin-6x reductase. (249 aa)
AGS73017.1Precorrin 6A synthase; COG2243 Precorrin-2 methylase. (259 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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