(46 nodes) Mixed, incl. Two-component regulatory system, and His Kinase A (phosphoacceptor) domain network (Streptomyces collinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGS67101.1	Two-component sensor; COG0642 Signal transduction histidine kinase. (442 aa)
	AGS67197.1	Hypothetical protein. (132 aa)
	AGS67198.1	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (244 aa)
	AGS67199.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (484 aa)
	AGS67200.1	Hypothetical protein; COG0510 Predicted choline kinase involved in LPS biosynthesis. (269 aa)
	AGS68479.1	Two-component system sensor kinase; COG5002 Signal transduction histidine kinase. (375 aa)
	AGS70359.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (226 aa)
	AGS70360.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (417 aa)
	AGS70362.1	Hypothetical protein. (51 aa)
	AGS70422.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (244 aa)
	AGS70423.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (487 aa)
	AGS70985.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (452 aa)
	AGS70986.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (234 aa)
	AGS70987.1	Hypothetical protein. (199 aa)
	AGS71045.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (240 aa)
	AGS71046.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (492 aa)
	AGS71061.1	ATPase domain-containing protein; COG0642 Signal transduction histidine kinase. (505 aa)
	AGS71062.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (223 aa)
	AGS71413.1	Integral membrane protein. (186 aa)
	AGS71414.1	Lipoprotein. (203 aa)
	AGS71415.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (533 aa)
	AGS71416.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (225 aa)
	AGS71417.1	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (245 aa)
	AGS71781.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (373 aa)
	AGS71782.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (246 aa)
	AGS71783.1	Hypothetical protein; COG0421 Spermidine synthase. (223 aa)
	AGS71784.1	Hypothetical protein. (279 aa)
	AGS71827.1	Two-component system response regulator; COG0784 FOG: CheY-like receiver. (178 aa)
	AGS71854.1	Winged helix family two component transcriptional regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (231 aa)
	AGS71855.1	Putative two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (487 aa)
	AGS71856.1	Hypothetical protein. (133 aa)
	AGS71857.1	Hypothetical protein. (96 aa)
	AGS72186.1	Response regulator receiver protein; COG0784 FOG: CheY-like receiver. (226 aa)
	AGS72208.1	Hypothetical protein; COG0607 Rhodanese-related sulfurtransferase. (136 aa)
	AGS72209.1	Cysteine dioxygenase. (183 aa)
	AGS72210.1	Monooxygenase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. (539 aa)
	AGS72215.1	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (228 aa)
	AGS72216.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (475 aa)
	AGS72293.1	Hypothetical protein. (57 aa)
	AGS72294.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (217 aa)
	AGS72295.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (415 aa)
	AGS72296.1	Hypothetical protein. (98 aa)
	AGS72297.1	Hypothetical protein. (311 aa)
	AGS73495.1	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase. (484 aa)
	AGS73496.1	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (244 aa)
	AGS73593.1	Two-component sensor; COG0642 Signal transduction histidine kinase. (442 aa)

Your Current Organism:

Streptomyces collinus

NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGS67101.1	AGS67198.1	B446_01325	B446_01830	Two-component sensor; COG0642 Signal transduction histidine kinase.	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.757
AGS67101.1	AGS68479.1	B446_01325	B446_08275	Two-component sensor; COG0642 Signal transduction histidine kinase.	Two-component system sensor kinase; COG5002 Signal transduction histidine kinase.	0.517
AGS67101.1	AGS70359.1	B446_01325	B446_17715	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.612
AGS67101.1	AGS70422.1	B446_01325	B446_18030	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.660
AGS67101.1	AGS70986.1	B446_01325	B446_20870	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.655
AGS67101.1	AGS71045.1	B446_01325	B446_21165	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.716
AGS67101.1	AGS71046.1	B446_01325	B446_21170	Two-component sensor; COG0642 Signal transduction histidine kinase.	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase.	0.570
AGS67101.1	AGS71061.1	B446_01325	B446_21245	Two-component sensor; COG0642 Signal transduction histidine kinase.	ATPase domain-containing protein; COG0642 Signal transduction histidine kinase.	0.668
AGS67101.1	AGS71062.1	B446_01325	B446_21250	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.694
AGS67101.1	AGS71416.1	B446_01325	B446_23020	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.684
AGS67101.1	AGS71782.1	B446_01325	B446_24855	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.678
AGS67101.1	AGS71827.1	B446_01325	B446_25080	Two-component sensor; COG0642 Signal transduction histidine kinase.	Two-component system response regulator; COG0784 FOG: CheY-like receiver.	0.625
AGS67101.1	AGS71854.1	B446_01325	B446_25215	Two-component sensor; COG0642 Signal transduction histidine kinase.	Winged helix family two component transcriptional regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.719
AGS67101.1	AGS72215.1	B446_01325	B446_27035	Two-component sensor; COG0642 Signal transduction histidine kinase.	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.654
AGS67101.1	AGS72294.1	B446_01325	B446_27430	Two-component sensor; COG0642 Signal transduction histidine kinase.	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.688
AGS67101.1	AGS73496.1	B446_01325	B446_33460	Two-component sensor; COG0642 Signal transduction histidine kinase.	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.757
AGS67197.1	AGS67198.1	B446_01825	B446_01830	Hypothetical protein.	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.432
AGS67197.1	AGS67199.1	B446_01825	B446_01835	Hypothetical protein.	Two-component system sensor kinase; COG0642 Signal transduction histidine kinase.	0.403
AGS67198.1	AGS67101.1	B446_01830	B446_01325	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Two-component sensor; COG0642 Signal transduction histidine kinase.	0.757
AGS67198.1	AGS67197.1	B446_01830	B446_01825	Two-component system regulator; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Hypothetical protein.	0.432