STRINGSTRING
AGS71768.1 AGS71768.1 AGS73578.1 AGS73578.1 AGS73576.1 AGS73576.1 AGS73519.1 AGS73519.1 AGS73475.1 AGS73475.1 AGS73386.1 AGS73386.1 AGS73151.1 AGS73151.1 AGS73113.1 AGS73113.1 AGS73059.1 AGS73059.1 AGS73038.1 AGS73038.1 AGS73037.1 AGS73037.1 tdh tdh AGS72946.1 AGS72946.1 AGS72927.1 AGS72927.1 AGS72895.1 AGS72895.1 zwf-2 zwf-2 AGS72886.1 AGS72886.1 AGS72865.1 AGS72865.1 AGS72762.1 AGS72762.1 AGS72672.1 AGS72672.1 AGS72580.1 AGS72580.1 AGS72484.1 AGS72484.1 AGS72459.1 AGS72459.1 dxr dxr gpsA gpsA leuB leuB AGS71982.1 AGS71982.1 ilvC ilvC AGS71976.1 AGS71976.1 AGS71859.1 AGS71859.1 AGS71830.1 AGS71830.1 AGS71448.1 AGS71448.1 mdh mdh AGS71291.1 AGS71291.1 AGS71290.1 AGS71290.1 guaB guaB murB murB AGS70692.1 AGS70692.1 AGS70649.1 AGS70649.1 AGS70473.1 AGS70473.1 AGS70469.1 AGS70469.1 AGS70466.1 AGS70466.1 AGS69987.1 AGS69987.1 AGS69896.1 AGS69896.1 AGS69816.1 AGS69816.1 AGS69728.1 AGS69728.1 AGS69713.1 AGS69713.1 AGS69675.1 AGS69675.1 AGS69647.1 AGS69647.1 AGS69517.1 AGS69517.1 AGS69390.1 AGS69390.1 AGS69331.1 AGS69331.1 AGS69287.1 AGS69287.1 AGS69237.1 AGS69237.1 AGS69217.1 AGS69217.1 hisD hisD zwf zwf AGS68791.1 AGS68791.1 AGS68717.1 AGS68717.1 AGS68471.1 AGS68471.1 aroE aroE AGS68340.1 AGS68340.1 AGS68206.1 AGS68206.1 AGS68197.1 AGS68197.1 AGS68065.1 AGS68065.1 iolG iolG AGS67613.1 AGS67613.1 AGS67463.1 AGS67463.1 AGS67219.1 AGS67219.1 AGS67175.1 AGS67175.1 AGS67118.1 AGS67118.1 AGS67116.1 AGS67116.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGS71768.1Malate oxidoreductase; COG0281 Malic enzyme. (406 aa)
AGS73578.1Glutathione-dependent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (391 aa)
AGS73576.1Glutathione-independent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (378 aa)
AGS73519.1COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (71 aa)
AGS73475.1Oxidoreductase domain-containing protein; COG0673 Predicted dehydrogenases and related proteins. (375 aa)
AGS73386.1COG1064 Zn-dependent alcohol dehydrogenases. (341 aa)
AGS73151.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (479 aa)
AGS73113.1Glutathione-independent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (378 aa)
AGS73059.1COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
AGS73038.1Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (396 aa)
AGS73037.1Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (334 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
AGS72946.1Fatty acid oxidative multifunctional enzyme; COG1024 Enoyl-CoA hydratase/carnithine racemase. (727 aa)
AGS72927.1Glutathione-dependent aldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (396 aa)
AGS72895.16-phospho-beta-glucosidase; COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases. (445 aa)
zwf-2Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (531 aa)
AGS72886.1COG1023 Predicted 6-phosphogluconate dehydrogenase. (292 aa)
AGS72865.1Dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (331 aa)
AGS72762.1Oxidoreductase; COG1250 3-hydroxyacyl-CoA dehydrogenase. (604 aa)
AGS72672.1Dehydrogenase; COG0673 Predicted dehydrogenases and related proteins. (340 aa)
AGS72580.1COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa)
AGS72484.1Hypothetical protein; COG1985 Pyrimidine reductase, riboflavin biosynthesis. (266 aa)
AGS72459.1Fatty acid oxidation complex alpha-subunit; COG1024 Enoyl-CoA hydratase/carnithine racemase. (709 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (405 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (336 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
AGS71982.1COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
AGS71976.1Oxidoreductase; COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (332 aa)
AGS71859.1COG1250 3-hydroxyacyl-CoA dehydrogenase. (282 aa)
AGS71830.1COG0460 Homoserine dehydrogenase. (429 aa)
AGS71448.1Molecular chaperone GroES; COG1064 Zn-dependent alcohol dehydrogenases. (347 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AGS71291.1COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (402 aa)
AGS71290.1Inosine 5-monophosphate dehydrogenase; COG0516 IMP dehydrogenase/GMP reductase. (374 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (351 aa)
AGS70692.1COG1250 3-hydroxyacyl-CoA dehydrogenase. (504 aa)
AGS70649.16-phosphogluconate dehydrogenase-like protein; COG1023 Predicted 6-phosphogluconate dehydrogenase. (291 aa)
AGS70473.1COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (322 aa)
AGS70469.1Bifunctional deaminase/reductase-like protein; COG1985 Pyrimidine reductase, riboflavin biosynthesis. (377 aa)
AGS70466.1Oxidoreductase; COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (315 aa)
AGS69987.1COG1004 Predicted UDP-glucose 6-dehydrogenase. (447 aa)
AGS69896.1Malate oxidoreductase; COG0281 Malic enzyme. (471 aa)
AGS69816.1Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (355 aa)
AGS69728.1Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (383 aa)
AGS69713.1Oxidoreductase; COG1064 Zn-dependent alcohol dehydrogenases. (347 aa)
AGS69675.1COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
AGS69647.1Sugar hydrolase; COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases. (421 aa)
AGS69517.1Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (325 aa)
AGS69390.1Oxidoreductase; COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (336 aa)
AGS69331.1COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (337 aa)
AGS69287.1Oxidoreductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (299 aa)
AGS69237.1Dehydrogenase; COG2030 Acyl dehydratase. (291 aa)
AGS69217.1Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (343 aa)
hisDBifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (512 aa)
AGS68791.1COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (329 aa)
AGS68717.1COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (349 aa)
AGS68471.1COG1250 3-hydroxyacyl-CoA dehydrogenase. (277 aa)
aroECOG0169 Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (267 aa)
AGS68340.1Inosine 5-monophosphate dehydrogenase; COG0516 IMP dehydrogenase/GMP reductase. (480 aa)
AGS68206.1Oxidoreductase; COG0673 Predicted dehydrogenases and related proteins. (318 aa)
AGS68197.1Glutathione-independent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (383 aa)
AGS68065.1Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases. (326 aa)
iolGMyo-inositol 2-dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (337 aa)
AGS67613.1Oxidoreductase. (298 aa)
AGS67463.1COG1250 3-hydroxyacyl-CoA dehydrogenase. (300 aa)
AGS67219.1Oxidoreductase domain-containing protein; COG0673 Predicted dehydrogenases and related proteins. (375 aa)
AGS67175.1COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (71 aa)
AGS67118.1Glutathione-independent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (378 aa)
AGS67116.1Glutathione-dependent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (391 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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