STRINGSTRING
AGS73430.1 AGS73430.1 AGS66875.1 AGS66875.1 AGS66924.1 AGS66924.1 AGS66929.1 AGS66929.1 AGS66935.1 AGS66935.1 AGS66937.1 AGS66937.1 AGS67012.1 AGS67012.1 AGS67020.1 AGS67020.1 AGS67022.1 AGS67022.1 AGS67023.1 AGS67023.1 AGS67024.1 AGS67024.1 AGS67034.1 AGS67034.1 AGS67051.1 AGS67051.1 AGS67131.1 AGS67131.1 AGS67141.1 AGS67141.1 AGS67147.1 AGS67147.1 kirAVI kirAVI kirAIV kirAIV kirAI kirAI AGS67201.1 AGS67201.1 AGS67265.1 AGS67265.1 AGS67279.1 AGS67279.1 AGS67282.1 AGS67282.1 AGS67283.1 AGS67283.1 AGS67490.1 AGS67490.1 AGS67530.1 AGS67530.1 AGS67565.1 AGS67565.1 AGS67612.1 AGS67612.1 AGS67635.1 AGS67635.1 AGS67644.1 AGS67644.1 AGS67660.1 AGS67660.1 AGS67662.1 AGS67662.1 AGS67754.1 AGS67754.1 AGS67759.1 AGS67759.1 AGS67773.1 AGS67773.1 AGS67776.1 AGS67776.1 AGS67777.1 AGS67777.1 AGS67778.1 AGS67778.1 AGS67790.1 AGS67790.1 AGS67830.1 AGS67830.1 AGS67973.1 AGS67973.1 AGS68049.1 AGS68049.1 AGS68078.1 AGS68078.1 ligB ligB AGS68092.1 AGS68092.1 AGS68093.1 AGS68093.1 bioD bioD AGS68170.1 AGS68170.1 AGS68228.1 AGS68228.1 AGS68259.1 AGS68259.1 AGS68350.1 AGS68350.1 carB carB carA carA AGS68358.1 AGS68358.1 alaS alaS hisS hisS thrS thrS pheT pheT pheS pheS AGS68493.1 AGS68493.1 pafA pafA mshC mshC AGS68579.1 AGS68579.1 AGS68586.1 AGS68586.1 AGS68625.1 AGS68625.1 pyrG pyrG tyrS tyrS cobN cobN cobB cobB ileS ileS murD murD murF murF murE murE AGS69057.1 AGS69057.1 AGS69125.1 AGS69125.1 AGS69142.1 AGS69142.1 AGS69178.1 AGS69178.1 nadE nadE AGS69262.1 AGS69262.1 AGS69347.1 AGS69347.1 AGS69349.1 AGS69349.1 AGS69350.1 AGS69350.1 glyQS glyQS AGS69465.1 AGS69465.1 AGS69473.1 AGS69473.1 AGS69507.1 AGS69507.1 AGS69518.1 AGS69518.1 leuS leuS AGS69565.1 AGS69565.1 AGS69588.1 AGS69588.1 valS valS AGS69656.1 AGS69656.1 AGS69689.1 AGS69689.1 AGS69706.1 AGS69706.1 AGS69734.1 AGS69734.1 AGS69747.1 AGS69747.1 AGS69748.1 AGS69748.1 AGS69756.1 AGS69756.1 AGS69799.1 AGS69799.1 AGS69806.1 AGS69806.1 AGS69867.1 AGS69867.1 fbiB fbiB AGS69977.1 AGS69977.1 purK purK AGS70117.1 AGS70117.1 AGS70201.1 AGS70201.1 AGS70231.1 AGS70231.1 AGS70255.1 AGS70255.1 AGS70257.1 AGS70257.1 AGS70258.1 AGS70258.1 AGS70268.1 AGS70268.1 cysS cysS AGS70461.1 AGS70461.1 purM purM purL purL purQ purQ purS purS purC purC purD purD AGS70549.1 AGS70549.1 serS serS aspS aspS metG metG metG-2 metG-2 AGS70778.1 AGS70778.1 AGS70785.1 AGS70785.1 purA purA AGS70880.1 AGS70880.1 acsA acsA tilS tilS panC panC trpS trpS argS argS lysK lysK AGS71035.1 AGS71035.1 AGS71092.1 AGS71092.1 AGS71093.1 AGS71093.1 guaA guaA sucC sucC sucD sucD AGS71353.1 AGS71353.1 trpS-2 trpS-2 AGS71429.1 AGS71429.1 AGS71433.1 AGS71433.1 AGS71434.1 AGS71434.1 AGS71435.1 AGS71435.1 AGS71688.1 AGS71688.1 AGS71702.1 AGS71702.1 AGS71808.1 AGS71808.1 AGS71828.1 AGS71828.1 atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC ligA ligA gatC gatC gatA gatA gatB gatB AGS72006.1 AGS72006.1 AGS72007.1 AGS72007.1 gltX gltX ddl ddl proS proS AGS72236.1 AGS72236.1 AGS72374.1 AGS72374.1 AGS72380.1 AGS72380.1 AGS72389.1 AGS72389.1 AGS72403.1 AGS72403.1 murC murC argG argG AGS72610.1 AGS72610.1 AGS72616.1 AGS72616.1 AGS72628.1 AGS72628.1 AGS72629.1 AGS72629.1 AGS72651.1 AGS72651.1 AGS72652.1 AGS72652.1 AGS72653.1 AGS72653.1 AGS72710.1 AGS72710.1 AGS72789.1 AGS72789.1 AGS72831.1 AGS72831.1 AGS72897.1 AGS72897.1 ligC ligC AGS72929.1 AGS72929.1 AGS73007.1 AGS73007.1 AGS73014.1 AGS73014.1 AGS73102.1 AGS73102.1 AGS73103.1 AGS73103.1 AGS73107.1 AGS73107.1 lysS lysS egtA egtA AGS73229.1 AGS73229.1 AGS73298.1 AGS73298.1 AGS73309.1 AGS73309.1 AGS73412.1 AGS73412.1 AGS73413.1 AGS73413.1 AGS73416.1 AGS73416.1 AGS73493.1 AGS73493.1 kirAI-2 kirAI-2 kirAIV-2 kirAIV-2 kirAVI-2 kirAVI-2 AGS73547.1 AGS73547.1 AGS73553.1 AGS73553.1 AGS73563.1 AGS73563.1 AGS73644.1 AGS73644.1 AGS73660.1 AGS73660.1 AGS73670.1 AGS73670.1 AGS73671.1 AGS73671.1 AGS73672.1 AGS73672.1 AGS73674.1 AGS73674.1 AGS73682.1 AGS73682.1 AGS73757.1 AGS73757.1 AGS73759.1 AGS73759.1 AGS73765.1 AGS73765.1 AGS73770.1 AGS73770.1 AGS73819.1 AGS73819.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AGS73430.1Capsule biosynthesis protein CapB; COG0285 Folylpolyglutamate synthase. (485 aa)
AGS66875.1Hypothetical protein; COG0603 Predicted PP-loop superfamily ATPase. (445 aa)
AGS66924.1Hypothetical protein; COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (434 aa)
AGS66929.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (500 aa)
AGS66935.1Hypothetical protein. (298 aa)
AGS66937.1Hypothetical protein; COG0439 Biotin carboxylase. (394 aa)
AGS67012.1Hypothetical protein; COG0367 Asparagine synthase (glutamine-hydrolyzing). (592 aa)
AGS67020.1Hypothetical protein; COG0439 Biotin carboxylase. (422 aa)
AGS67022.1COG1020 Non-ribosomal peptide synthetase modules and related proteins; Belongs to the ATP-dependent AMP-binding enzyme family. (539 aa)
AGS67023.1Condensation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (418 aa)
AGS67024.1COG0439 Biotin carboxylase. (799 aa)
AGS67034.1Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (526 aa)
AGS67051.1Urea amidolyase; COG0439 Biotin carboxylase. (1195 aa)
AGS67131.1COG1020 Non-ribosomal peptide synthetase modules and related proteins. (3518 aa)
AGS67141.1COG1020 Non-ribosomal peptide synthetase modules and related proteins; Belongs to the ATP-dependent AMP-binding enzyme family. (1073 aa)
AGS67147.1Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (2417 aa)
kirAVICOG3321 Polyketide synthase modules and related proteins; polyketide synthase of the cis-AT type. (2898 aa)
kirAIVCOG3321 Polyketide synthase modules and related proteins; polyketide synthase of the trans-AT type. (6398 aa)
kirAICOG3321 Polyketide synthase modules and related proteins; polyketide synthase of the trans-AT type. (1999 aa)
AGS67201.1COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (360 aa)
AGS67265.1Capsule biosynthesis protein CapB; COG0285 Folylpolyglutamate synthase. (485 aa)
AGS67279.1AMP-dependent synthetase/ligase; COG1541 Coenzyme F390 synthetase. (420 aa)
AGS67282.1Acyl-protein synthetase LuxE. (388 aa)
AGS67283.1Hypothetical protein; COG1541 Coenzyme F390 synthetase. (835 aa)
AGS67490.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (497 aa)
AGS67530.1Glutamate-cysteine ligase. (492 aa)
AGS67565.1(NiFe) hydrogenase maturation protein HypF; COG0068 Hydrogenase maturation factor. (782 aa)
AGS67612.1Hypothetical protein; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (327 aa)
AGS67635.1Hypothetical protein; COG1793 ATP-dependent DNA ligase. (203 aa)
AGS67644.1COG1793 ATP-dependent DNA ligase. (327 aa)
AGS67660.1Carboxylate-amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (362 aa)
AGS67662.1long-chain-fatty-acid-CoA ligase; COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (634 aa)
AGS67754.1COG0367 Asparagine synthase (glutamine-hydrolyzing). (613 aa)
AGS67759.1Non-ribosomal peptide synthetase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (577 aa)
AGS67773.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (539 aa)
AGS67776.1phenylacetate:CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (431 aa)
AGS67777.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (498 aa)
AGS67778.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (516 aa)
AGS67790.1Thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (316 aa)
AGS67830.1COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (134 aa)
AGS67973.1Hypothetical protein. (1224 aa)
AGS68049.1NRPS protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins; Belongs to the ATP-dependent AMP-binding enzyme family. (1087 aa)
AGS68078.1Hypothetical protein. (64 aa)
ligBATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (512 aa)
AGS68092.1Ligase; COG0769 UDP-N-acetylmuramyl tripeptide synthase. (412 aa)
AGS68093.1COG3442 Predicted glutamine amidotransferase. (242 aa)
bioDDithiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (238 aa)
AGS68170.1Hypothetical protein. (495 aa)
AGS68228.1Hypothetical protein; COG0840 Methyl-accepting chemotaxis protein. (505 aa)
AGS68259.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (655 aa)
AGS68350.1Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
carBCOG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1102 aa)
carACOG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (385 aa)
AGS68358.1Integral membrane protein. (183 aa)
alaSalanyl-tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (890 aa)
hisSCOG0124 Histidyl-tRNA synthetase. (420 aa)
thrSCOG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (658 aa)
pheTphenylalanyl-tRNA ligase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (840 aa)
pheSCOG0016 Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (373 aa)
AGS68493.1COG0174 Glutamine synthetase. (454 aa)
pafAProteasome component; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (453 aa)
mshCcysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (409 aa)
AGS68579.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (559 aa)
AGS68586.1Hypothetical protein; COG0073 EMAP domain. (355 aa)
AGS68625.1Hypothetical protein; COG1530 Ribonucleases G and E. (166 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (549 aa)
tyrStyrosyl-tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (422 aa)
cobNCobaltochelatase subunit CobN; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. (1210 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa)
ileSisoleucyl-tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1047 aa)
murDUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (475 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate- D-alanyl-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (467 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (505 aa)
AGS69057.1COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (598 aa)
AGS69125.1COG0174 Glutamine synthetase. (469 aa)
AGS69142.1Glutamate--ammonia ligase; COG0174 Glutamine synthetase. (343 aa)
AGS69178.1COG0174 Glutamine synthetase. (453 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (679 aa)
AGS69262.1Carboxylase. (347 aa)
AGS69347.1Hypothetical protein. (290 aa)
AGS69349.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (482 aa)
AGS69350.1COG0777 Acetyl-CoA carboxylase beta subunit. (458 aa)
glyQSglycyl-tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (460 aa)
AGS69465.1COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (623 aa)
AGS69473.1Putative type I polyketide synthase component; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (570 aa)
AGS69507.1Putative AMP-binding protein; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (514 aa)
AGS69518.1COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (520 aa)
leuSCOG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (960 aa)
AGS69565.1Solo B3/4 domain-containing protein. (235 aa)
AGS69588.1COG0285 Folylpolyglutamate synthase. (503 aa)
valSvalyl-tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (876 aa)
AGS69656.1COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (448 aa)
AGS69689.1Integral membrane protein; COG3307 Lipid A core - O-antigen ligase and related enzymes. (465 aa)
AGS69706.1IolD protein; COG3962 Acetolactate synthase; Belongs to the TPP enzyme family. (628 aa)
AGS69734.1Tripeptidyl aminopeptidase. (477 aa)
AGS69747.1COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (538 aa)
AGS69748.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (641 aa)
AGS69756.1Siderophore biosynthetic enzyme; COG4264 Siderophore synthetase component. (589 aa)
AGS69799.1AMP-binding protein; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (559 aa)
AGS69806.1Membrane protein. (187 aa)
AGS69867.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (448 aa)
fbiBF420-0--gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. (440 aa)
AGS69977.1Hypothetical protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (251 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (372 aa)
AGS70117.1Ligase; COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (206 aa)
AGS70201.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (530 aa)
AGS70231.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (505 aa)
AGS70255.14-coumarate:CoA ligase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (522 aa)
AGS70257.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (613 aa)
AGS70258.1COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (532 aa)
AGS70268.1Hypothetical protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (190 aa)
cysSCOG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa)
AGS70461.1Hypothetical protein. (692 aa)
purMCOG0150 Phosphoribosylaminoimidazole (AIR) synthetase. (355 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (752 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (226 aa)
purSPhosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (90 aa)
purCCOG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (299 aa)
purDCOG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (416 aa)
AGS70549.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (551 aa)
serSseryl-tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa)
aspSaspartyl-tRNA ligase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (587 aa)
metGmethionyl-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (532 aa)
metG-2methionyl-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (571 aa)
AGS70778.1Cysteine synthase; COG0439 Biotin carboxylase. (420 aa)
AGS70785.1Lysine biosynthesis protein LysX; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the RimK family. (289 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
AGS70880.1Hypothetical protein. (155 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (354 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (333 aa)
trpStryptophanyl-tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (341 aa)
argSCOG0018 Arginyl-tRNA synthetase. (589 aa)
lysKCOG1384 Lysyl-tRNA synthetase (class I); Belongs to the class-I aminoacyl-tRNA synthetase family. (579 aa)
AGS71035.1Hypothetical protein. (397 aa)
AGS71092.1Long-chain-fatty acid CoA ligase; COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (652 aa)
AGS71093.1Biotin carboxylase. (272 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
AGS71353.1COG0754 Glutathionylspermidine synthase. (394 aa)
trpS-2tryptophanyl-tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (338 aa)
AGS71429.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (590 aa)
AGS71433.1Hypothetical protein. (69 aa)
AGS71434.1COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (534 aa)
AGS71435.1Ligase; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. (286 aa)
AGS71688.1Molybdopterin biosynthesis-like protein MoeZ; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (392 aa)
AGS71702.1Hypothetical protein. (416 aa)
AGS71808.1DNA ligase; COG3285 Predicted eukaryotic-type DNA primase. (281 aa)
AGS71828.1COG0018 Arginyl-tRNA synthetase. (482 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (256 aa)
atpEATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa)
atpFF0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (182 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (271 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (530 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (305 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (478 aa)
atpCF0F1 ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (125 aa)
ligANAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (731 aa)
gatCasparaginyl/glutamyl-tRNA amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (98 aa)
gatAaspartyl/glutamyl-tRNA amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (499 aa)
gatBaspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (504 aa)
AGS72006.1COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (528 aa)
AGS72007.1Hypothetical protein. (61 aa)
gltXglutamyl-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (475 aa)
ddlD-alanyl-alanine synthetase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (385 aa)
proSprolyl-tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacyla [...] (567 aa)
AGS72236.1Iron transport protein; COG4264 Siderophore synthetase component. (722 aa)
AGS72374.1Fatty acid-CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (530 aa)
AGS72380.1COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (514 aa)
AGS72389.1COG0172 Seryl-tRNA synthetase. (425 aa)
AGS72403.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (533 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (463 aa)
argGCOG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (482 aa)
AGS72610.1Hypothetical protein. (521 aa)
AGS72616.1Mur ligase middle domain-containing protein. (550 aa)
AGS72628.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (557 aa)
AGS72629.1AMP-binding domain protein; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (545 aa)
AGS72651.1COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (420 aa)
AGS72652.1Iron transport protein; COG4264 Siderophore synthetase component. (514 aa)
AGS72653.1Iron transport protein; COG4264 Siderophore synthetase component. (499 aa)
AGS72710.1COG0095 Lipoate-protein ligase A. (354 aa)
AGS72789.1Gas vesicle synthesis protein. (256 aa)
AGS72831.1long-chain-fatty-acid-CoA ligase; COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (608 aa)
AGS72897.1Hypothetical protein. (375 aa)
ligCCOG1793 ATP-dependent DNA ligase. (354 aa)
AGS72929.1Hypothetical protein; COG3285 Predicted eukaryotic-type DNA primase. (347 aa)
AGS73007.1COG0174 Glutamine synthetase. (467 aa)
AGS73014.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (503 aa)
AGS73102.1COG0439 Biotin carboxylase. (415 aa)
AGS73103.1COG0143 Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (543 aa)
AGS73107.1Argininosuccinate lyase; COG0439 Biotin carboxylase. (407 aa)
lysSlysyl-tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (1092 aa)
egtAGlutamate/cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (449 aa)
AGS73229.1L-amino acid ligase; COG0439 Biotin carboxylase. (457 aa)
AGS73298.1COG1309 Transcriptional regulator. (239 aa)
AGS73309.1Hypothetical protein; COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase. (177 aa)
AGS73412.1Hypothetical protein; COG1541 Coenzyme F390 synthetase. (835 aa)
AGS73413.1Acyl-protein synthetase LuxE. (388 aa)
AGS73416.1AMP-dependent synthetase/ligase; COG1541 Coenzyme F390 synthetase. (420 aa)
AGS73493.1COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (359 aa)
kirAI-2COG3321 Polyketide synthase modules and related proteins; polyketide synthase of the trans-AT type. (1999 aa)
kirAIV-2COG3321 Polyketide synthase modules and related proteins; polyketide synthase of the trans-AT type. (6398 aa)
kirAVI-2COG3321 Polyketide synthase modules and related proteins; polyketide synthase of the cis-AT type. (2898 aa)
AGS73547.1Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (2417 aa)
AGS73553.1COG1020 Non-ribosomal peptide synthetase modules and related proteins. (1073 aa)
AGS73563.1COG1020 Non-ribosomal peptide synthetase modules and related proteins. (3518 aa)
AGS73644.1Urea amidolyase; COG0439 Biotin carboxylase. (1195 aa)
AGS73660.1Amino acid adenylation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (526 aa)
AGS73670.1COG0439 Biotin carboxylase. (799 aa)
AGS73671.1Condensation domain-containing protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (418 aa)
AGS73672.1COG1020 Non-ribosomal peptide synthetase modules and related proteins. (539 aa)
AGS73674.1Hypothetical protein; COG0439 Biotin carboxylase. (422 aa)
AGS73682.1Hypothetical protein; COG0367 Asparagine synthase (glutamine-hydrolyzing). (592 aa)
AGS73757.1Hypothetical protein; COG0439 Biotin carboxylase. (394 aa)
AGS73759.1Hypothetical protein. (298 aa)
AGS73765.1COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (500 aa)
AGS73770.1Hypothetical protein; COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (434 aa)
AGS73819.1Hypothetical protein; COG0603 Predicted PP-loop superfamily ATPase. (445 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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