STRINGSTRING
kirCII kirCII AGS66925.1 AGS66925.1 AGS66927.1 AGS66927.1 AGS66930.1 AGS66930.1 AGS67027.1 AGS67027.1 kirAIII kirAIII AGS67229.1 AGS67229.1 AGS67257.1 AGS67257.1 AGS67442.1 AGS67442.1 AGS67616.1 AGS67616.1 AGS67698.1 AGS67698.1 AGS67758.1 AGS67758.1 AGS67902.1 AGS67902.1 AGS68048.1 AGS68048.1 AGS68099.1 AGS68099.1 AGS68125.1 AGS68125.1 bioA bioA AGS68156.1 AGS68156.1 AGS68186.1 AGS68186.1 AGS68187.1 AGS68187.1 gcvP gcvP AGS68289.1 AGS68289.1 argD argD AGS68535.1 AGS68535.1 AGS68576.1 AGS68576.1 AGS68756.1 AGS68756.1 AGS68764.1 AGS68764.1 AGS68818.1 AGS68818.1 AGS68926.1 AGS68926.1 hisC hisC AGS69004.1 AGS69004.1 AGS69080.1 AGS69080.1 AGS69336.1 AGS69336.1 AGS69706.1 AGS69706.1 AGS69738.1 AGS69738.1 AGS69753.1 AGS69753.1 AGS70252.1 AGS70252.1 serC serC AGS70315.1 AGS70315.1 pat pat AGS70605.1 AGS70605.1 AGS70624.1 AGS70624.1 AGS70772.1 AGS70772.1 AGS70773.1 AGS70773.1 AGS70808.1 AGS70808.1 kynU kynU AGS70843.1 AGS70843.1 AGS70940.1 AGS70940.1 AGS71025.1 AGS71025.1 hemL hemL AGS71141.1 AGS71141.1 AGS71201.1 AGS71201.1 alr alr AGS71283.1 AGS71283.1 AGS71319.1 AGS71319.1 glyA-2 glyA-2 AGS71383.1 AGS71383.1 AGS71454.1 AGS71454.1 AGS71458.1 AGS71458.1 AGS71478.1 AGS71478.1 AGS71569.1 AGS71569.1 AGS71639.1 AGS71639.1 kgd kgd lysA lysA AGS71831.1 AGS71831.1 glyA-3 glyA-3 AGS71887.1 AGS71887.1 AGS71911.1 AGS71911.1 glyA glyA AGS71955.1 AGS71955.1 AGS71979.1 AGS71979.1 AGS72101.1 AGS72101.1 AGS72110.1 AGS72110.1 AGS72130.1 AGS72130.1 AGS72235.1 AGS72235.1 AGS72241.1 AGS72241.1 AGS72342.1 AGS72342.1 AGS72343.1 AGS72343.1 AGS72398.1 AGS72398.1 AGS72402.1 AGS72402.1 AGS72424.1 AGS72424.1 dxs dxs AGS72591.1 AGS72591.1 AGS72631.1 AGS72631.1 AGS72648.1 AGS72648.1 AGS72699.1 AGS72699.1 dxs-2 dxs-2 AGS72805.1 AGS72805.1 AGS72807.1 AGS72807.1 AGS72880.1 AGS72880.1 dxs-3 dxs-3 AGS72979.1 AGS72979.1 kbl kbl AGS73087.1 AGS73087.1 AGS73090.1 AGS73090.1 AGS73342.1 AGS73342.1 AGS73438.1 AGS73438.1 AGS73465.1 AGS73465.1 kirAIII-2 kirAIII-2 kirCII-2 kirCII-2 AGS73667.1 AGS73667.1 AGS73764.1 AGS73764.1 AGS73767.1 AGS73767.1 AGS73769.1 AGS73769.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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kirCIIAcyltransferase; COG3321 Polyketide synthase modules and related proteins; KirCII has specificity for ethylmalonyl-CoA, which is selectively transferred to ACP5 of KirAII. (445 aa)
AGS66925.1COG3319 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases. (187 aa)
AGS66927.1Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (473 aa)
AGS66930.1Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (434 aa)
AGS67027.1Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (434 aa)
kirAIIINon-ribosomal peptide synthetase-polyketide synthase hybrid; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (1550 aa)
AGS67229.1Class V aminotransferase; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (396 aa)
AGS67257.1Pyruvate dehydrogenase/oxidase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (585 aa)
AGS67442.1COG1020 Non-ribosomal peptide synthetase modules and related proteins. (1288 aa)
AGS67616.1Aminotransferase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
AGS67698.1COG1171 Threonine dehydratase. (322 aa)
AGS67758.1COG3321 Polyketide synthase modules and related proteins. (4600 aa)
AGS67902.1COG3217 Uncharacterized Fe-S protein. (274 aa)
AGS68048.1NRPS protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (879 aa)
AGS68099.1COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa)
AGS68125.18-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. (375 aa)
bioAAdenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa)
AGS68156.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (399 aa)
AGS68186.1COG3321 Polyketide synthase modules and related proteins; Belongs to the P-Pant transferase superfamily. (1666 aa)
AGS68187.1Beta-ketoacyl synthase; COG2070 Dioxygenases related to 2-nitropropane dioxygenase. (2521 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
AGS68289.1COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (501 aa)
argDCOG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
AGS68535.15-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1156 aa)
AGS68576.1Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (450 aa)
AGS68756.1Hypothetical protein; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (363 aa)
AGS68764.1Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
AGS68818.1Aminotransferase; COG0520 Selenocysteine lyase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
AGS68926.1Amino acid decarboxylase; COG0076 Glutamate decarboxylase and related PLP-dependent proteins. (452 aa)
hisCCOG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa)
AGS69004.1Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (239 aa)
AGS69080.1Pyridoxalphosphate dependent protein; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Belongs to the sulfur carrier protein TusA family. (462 aa)
AGS69336.1Aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (591 aa)
AGS69706.1IolD protein; COG3962 Acetolactate synthase; Belongs to the TPP enzyme family. (628 aa)
AGS69738.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (539 aa)
AGS69753.1Decarboxylase; COG0076 Glutamate decarboxylase and related PLP-dependent proteins. (480 aa)
AGS70252.1Iron/ascorbate-dependent oxidoreductase; COG3491 Isopenicillin N synthase and related dioxygenases; Belongs to the iron/ascorbate-dependent oxidoreductase family. (343 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
AGS70315.1COG0498 Threonine synthase. (392 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
AGS70605.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (382 aa)
AGS70624.1Hypothetical protein; COG0787 Alanine racemase. (343 aa)
AGS70772.1Amino acid adenylation domain-containing protein; COG3321 Polyketide synthase modules and related proteins. (2302 aa)
AGS70773.1type-I PKS; COG3321 Polyketide synthase modules and related proteins. (3118 aa)
AGS70808.1Aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (391 aa)
kynUHydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (394 aa)
AGS70843.1Hypothetical protein; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
AGS70940.1COG0076 Glutamate decarboxylase and related PLP-dependent proteins; Belongs to the group II decarboxylase family. (468 aa)
AGS71025.1Aminotransferase; COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (401 aa)
hemLCOG0001 Glutamate-1-semialdehyde aminotransferase. (439 aa)
AGS71141.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (353 aa)
AGS71201.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (408 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (382 aa)
AGS71283.1COG2258 Uncharacterized protein conserved in bacteria. (222 aa)
AGS71319.1COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding). (136 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (483 aa)
AGS71383.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (526 aa)
AGS71454.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (384 aa)
AGS71458.1COG1171 Threonine dehydratase. (409 aa)
AGS71478.1Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (403 aa)
AGS71569.1COG1020 Non-ribosomal peptide synthetase modules and related proteins. (1678 aa)
AGS71639.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (365 aa)
kgdAlpha-ketoglutarate decarboxylase; COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (1268 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
AGS71831.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
AGS71887.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (566 aa)
AGS71911.1COG0058 Glucan phosphorylase. (872 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
AGS71955.1Pyridoxal-phosphate-dependent aminotransferase; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (389 aa)
AGS71979.1Acetolactate synthase 1 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (616 aa)
AGS72101.1ABC transporter substrate-binding protein; COG4143 ABC-type thiamine transport system, periplasmic component. (360 aa)
AGS72110.1Hypothetical protein; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
AGS72130.1COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
AGS72235.1Class III aminotransferase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (493 aa)
AGS72241.1Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (966 aa)
AGS72342.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (724 aa)
AGS72343.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (602 aa)
AGS72398.1COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)
AGS72402.1COG3321 Polyketide synthase modules and related proteins. (1902 aa)
AGS72424.1COG0019 Diaminopimelate decarboxylase. (398 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
AGS72591.1Pyruvate dehydrogenase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (580 aa)
AGS72631.1COG3960 Glyoxylate carboligase; Belongs to the TPP enzyme family. (595 aa)
AGS72648.1Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (402 aa)
AGS72699.1Class III aminotransferase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
dxs-21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (614 aa)
AGS72805.1COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (599 aa)
AGS72807.1Hypothetical protein; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (418 aa)
AGS72880.1Hypothetical protein. (153 aa)
dxs-31-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa)
AGS72979.1Aminotransferase; COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (399 aa)
AGS73087.1COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (341 aa)
AGS73090.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (591 aa)
AGS73342.1NRPS protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (6187 aa)
AGS73438.1Pyruvate dehydrogenase/oxidase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (585 aa)
AGS73465.1Class V aminotransferase; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (396 aa)
kirAIII-2Non-ribosomal peptide synthetase-polyketide synthase hybrid; COG1020 Non-ribosomal peptide synthetase modules and related proteins. (1550 aa)
kirCII-2Acyltransferase; COG3321 Polyketide synthase modules and related proteins; KirCII has specificity for ethylmalonyl-CoA, which is selectively transferred to ACP5 of KirAII. (445 aa)
AGS73667.1Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (434 aa)
AGS73764.1Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase. (434 aa)
AGS73767.1COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB). (473 aa)
AGS73769.1COG3319 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases. (187 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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