STRINGSTRING
AGS72274.1 AGS72274.1 AGS68425.1 AGS68425.1 cobT-2 cobT-2 AGS68423.1 AGS68423.1 AGS68093.1 AGS68093.1 AGS68078.1 AGS68078.1 AGS67973.1 AGS67973.1 AGS67964.1 AGS67964.1 hemL hemL AGS71858.1 AGS71858.1 hemH hemH hemE hemE AGS72468.1 AGS72468.1 AGS72469.1 AGS72469.1 AGS72541.1 AGS72541.1 AGS72610.1 AGS72610.1 AGS72651.1 AGS72651.1 AGS73016.1 AGS73016.1 AGS73017.1 AGS73017.1 AGS67339.1 AGS67339.1 AGS71024.1 AGS71024.1 AGS71022.1 AGS71022.1 hemC hemC AGS67616.1 AGS67616.1 hemA hemA AGS70610.1 AGS70610.1 AGS70091.1 AGS70091.1 AGS69902.1 AGS69902.1 AGS69806.1 AGS69806.1 AGS69734.1 AGS69734.1 hemC-2 hemC-2 AGS69656.1 AGS69656.1 AGS69463.1 AGS69463.1 AGS69366.1 AGS69366.1 AGS69118.1 AGS69118.1 cobS cobS cobT cobT AGS69095.1 AGS69095.1 ctaB ctaB AGS68827.1 AGS68827.1 AGS68755.1 AGS68755.1 AGS68754.1 AGS68754.1 AGS68753.1 AGS68753.1 AGS68752.1 AGS68752.1 AGS68751.1 AGS68751.1 AGS68749.1 AGS68749.1 cobB cobB AGS68747.1 AGS68747.1 AGS68746.1 AGS68746.1 cobN cobN cobQ cobQ cobD cobD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGS72274.1ATP/GTP-binding protein; COG0523 Putative GTPases (G3E family). (359 aa)
AGS68425.1precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. (408 aa)
cobT-2Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1417 aa)
AGS68423.1uroporphyrin-III methyltransferase; COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); Belongs to the precorrin methyltransferase family. (409 aa)
AGS68093.1COG3442 Predicted glutamine amidotransferase. (242 aa)
AGS68078.1Hypothetical protein. (64 aa)
AGS67973.1Hypothetical protein. (1224 aa)
AGS67964.1Hypothetical protein. (306 aa)
hemLCOG0001 Glutamate-1-semialdehyde aminotransferase. (439 aa)
AGS71858.1Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (375 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa)
AGS72468.1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (472 aa)
AGS72469.1Hypothetical protein. (243 aa)
AGS72541.1Hypothetical protein. (246 aa)
AGS72610.1Hypothetical protein. (521 aa)
AGS72651.1COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (420 aa)
AGS73016.1COG2099 Precorrin-6x reductase. (249 aa)
AGS73017.1Precorrin 6A synthase; COG2243 Precorrin-2 methylase. (259 aa)
AGS67339.1Hypothetical protein; COG0523 Putative GTPases (G3E family). (389 aa)
AGS71024.1COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (310 aa)
AGS71022.1uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; COG0007 Uroporphyrinogen-III methylase. (569 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (303 aa)
AGS67616.1Aminotransferase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (566 aa)
AGS70610.1COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol. (139 aa)
AGS70091.1COG0310 ABC-type Co2+ transport system, permease component. (349 aa)
AGS69902.1Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; COG1587 Uroporphyrinogen-III synthase. (387 aa)
AGS69806.1Membrane protein. (187 aa)
AGS69734.1Tripeptidyl aminopeptidase. (477 aa)
hemC-2Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (311 aa)
AGS69656.1COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (448 aa)
AGS69463.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (410 aa)
AGS69366.1Hypothetical protein. (292 aa)
AGS69118.1Oxidoreductase; COG1233 Phytoene dehydrogenase and related proteins. (454 aa)
cobSCobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (261 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (378 aa)
AGS69095.1COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase. (400 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (306 aa)
AGS68827.1COG1612 Uncharacterized protein required for cytochrome oxidase assembly. (336 aa)
AGS68755.1Metal binding protein. (303 aa)
AGS68754.1precorrin-8X methylmutase; COG2082 Precorrin isomerase. (195 aa)
AGS68753.1Precorrin methylase; COG2073 Cobalamin biosynthesis protein CbiG. (566 aa)
AGS68752.1precorrin-6Y C5,15-methyltransferase; COG2241 Precorrin-6B methylase 1. (413 aa)
AGS68751.1COG2875 Precorrin-4 methylase. (272 aa)
AGS68749.1COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. (247 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa)
AGS68747.1cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; COG2109 ATP:corrinoid adenosyltransferase. (199 aa)
AGS68746.1COG1239 Mg-chelatase subunit ChlI. (670 aa)
cobNCobaltochelatase subunit CobN; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. (1210 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (314 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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