STRINGSTRING
AGS71873.1 AGS71873.1 glyA glyA gcvH gcvH gcvT gcvT AGS71986.1 AGS71986.1 AGS72018.1 AGS72018.1 arcA arcA AGS72422.1 AGS72422.1 AGS72459.1 AGS72459.1 AGS72460.1 AGS72460.1 AGS72565.1 AGS72565.1 AGS72631.1 AGS72631.1 AGS72688.1 AGS72688.1 AGS73597.1 AGS73597.1 AGS72739.1 AGS72739.1 paaA paaA AGS72776.1 AGS72776.1 AGS72777.1 AGS72777.1 AGS72808.1 AGS72808.1 AGS72810.1 AGS72810.1 AGS72873.1 AGS72873.1 anmK anmK AGS72920.1 AGS72920.1 AGS72922.1 AGS72922.1 AGS72927.1 AGS72927.1 AGS72944.1 AGS72944.1 AGS72945.1 AGS72945.1 AGS72946.1 AGS72946.1 AGS72988.1 AGS72988.1 tdh tdh AGS73013.1 AGS73013.1 egtD egtD AGS73296.1 AGS73296.1 AGS73309.1 AGS73309.1 AGS73505.1 AGS73505.1 AGS73578.1 AGS73578.1 kirHVI-2 kirHVI-2 AGS73668.1 AGS73668.1 AGS67026.1 AGS67026.1 AGS67097.1 AGS67097.1 AGS67116.1 AGS67116.1 kirHVI kirHVI AGS67189.1 AGS67189.1 AGS67383.1 AGS67383.1 AGS67475.1 AGS67475.1 AGS67769.1 AGS67769.1 AGS67770.1 AGS67770.1 glsA glsA AGS68072.1 AGS68072.1 AGS68199.1 AGS68199.1 gcvP gcvP AGS68263.1 AGS68263.1 AGS68296.1 AGS68296.1 AGS68327.1 AGS68327.1 AGS68350.1 AGS68350.1 pdxT pdxT AGS68489.1 AGS68489.1 AGS68585.1 AGS68585.1 hmgA hmgA AGS68606.1 AGS68606.1 AGS68659.1 AGS68659.1 AGS68758.1 AGS68758.1 AGS68766.1 AGS68766.1 AGS68785.1 AGS68785.1 AGS68791.1 AGS68791.1 aroQ aroQ AGS68939.1 AGS68939.1 AGS68953.1 AGS68953.1 AGS69244.1 AGS69244.1 AGS69271.1 AGS69271.1 AGS69446.1 AGS69446.1 AGS69447.1 AGS69447.1 AGS69480.1 AGS69480.1 AGS69819.1 AGS69819.1 AGS69878.1 AGS69878.1 AGS69935.1 AGS69935.1 hutI hutI hutU hutU AGS70016.1 AGS70016.1 AGS70020.1 AGS70020.1 AGS70202.1 AGS70202.1 AGS70213.1 AGS70213.1 AGS70226.1 AGS70226.1 murQ murQ dtd dtd AGS70483.1 AGS70483.1 AGS70551.1 AGS70551.1 AGS70615.1 AGS70615.1 kynA kynA kynU kynU AGS70940.1 AGS70940.1 AGS71052.1 AGS71052.1 AGS71126.1 AGS71126.1 glyA-2 glyA-2 hutH hutH pckG pckG AGS71482.1 AGS71482.1 AGS71673.1 AGS71673.1 nagB nagB AGS71799.1 AGS71799.1 glyA-3 glyA-3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AGS71873.1Acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
AGS71986.1COG0506 Proline dehydrogenase. (308 aa)
AGS72018.1Hypothetical protein; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (261 aa)
arcACOG2235 Arginine deiminase. (407 aa)
AGS72422.1Hypothetical protein. (343 aa)
AGS72459.1Fatty acid oxidation complex alpha-subunit; COG1024 Enoyl-CoA hydratase/carnithine racemase. (709 aa)
AGS72460.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
AGS72565.1Carboxyvinyl-carboxyphosphonate phosphorylmutase; COG2513 PEP phosphonomutase and related enzymes. (287 aa)
AGS72631.1COG3960 Glyoxylate carboligase; Belongs to the TPP enzyme family. (595 aa)
AGS72688.1Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (211 aa)
AGS73597.1Beta-lactamase domain-containing protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (304 aa)
AGS72739.1COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin. (284 aa)
paaAphenylacetate-CoA oxygenase subunit PaaA. (340 aa)
AGS72776.1phenylacetate-CoA oxygenase subunit PaaB; COG3460 Uncharacterized enzyme of phenylacetate metabolism. (100 aa)
AGS72777.1Phenylacetic acid degradation protein PaaC. (277 aa)
AGS72808.1Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (429 aa)
AGS72810.1Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (263 aa)
AGS72873.1Saccharopine dehydrogenase. (353 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (386 aa)
AGS72920.13-carboxy-cis,cis-muconate cycloisomerase; COG0015 Adenylosuccinate lyase. (452 aa)
AGS72922.1COG3485 Protocatechuate 3,4-dioxygenase beta subunit. (261 aa)
AGS72927.1Glutathione-dependent aldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (396 aa)
AGS72944.1Fatty acid-CoA racemase; COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (394 aa)
AGS72945.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
AGS72946.1Fatty acid oxidative multifunctional enzyme; COG1024 Enoyl-CoA hydratase/carnithine racemase. (727 aa)
AGS72988.1Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (415 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
AGS73013.1beta-ketoadipyl-CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
egtDHypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (320 aa)
AGS73296.1COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (543 aa)
AGS73309.1Hypothetical protein; COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase. (177 aa)
AGS73505.1Hypothetical protein. (350 aa)
AGS73578.1Glutathione-dependent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (391 aa)
kirHVI-2Putative phytanoyl-CoA dioxygenase; COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin. (281 aa)
AGS73668.1COG1509 Lysine 2,3-aminomutase. (444 aa)
AGS67026.1COG1509 Lysine 2,3-aminomutase. (444 aa)
AGS67097.1Beta-lactamase domain-containing protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (304 aa)
AGS67116.1Glutathione-dependent formaldehyde dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (391 aa)
kirHVIPutative dioxygenase; COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin. (281 aa)
AGS67189.1Hypothetical protein. (350 aa)
AGS67383.1Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (279 aa)
AGS67475.1COG1231 Monoamine oxidase. (435 aa)
AGS67769.1COG0183 Acetyl-CoA acetyltransferase. (388 aa)
AGS67770.1Lipid-transfer protein; COG0183 Acetyl-CoA acetyltransferase. (349 aa)
glsACOG2066 Glutaminase; Belongs to the glutaminase family. (312 aa)
AGS68072.1Putative peptidase M38 family protein; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (539 aa)
AGS68199.13-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
AGS68263.1Lipid-transfer protein; COG0183 Acetyl-CoA acetyltransferase. (396 aa)
AGS68296.1Hypothetical protein; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (537 aa)
AGS68327.1COG1231 Monoamine oxidase. (565 aa)
AGS68350.1Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa)
AGS68489.1Hypothetical protein; COG3616 Predicted amino acid aldolase or racemase. (400 aa)
AGS68585.1Hypothetical protein. (244 aa)
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (437 aa)
AGS68606.1COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (398 aa)
AGS68659.1COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa)
AGS68758.1Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (363 aa)
AGS68766.1Ectoine hydroxylase. (295 aa)
AGS68785.15-dehydro-4-deoxyglucarate dehydratase; COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (313 aa)
AGS68791.1COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (329 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa)
AGS68939.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
AGS68953.1COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (406 aa)
AGS69244.1Lipid-transfer protein; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
AGS69271.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
AGS69446.1Glucarate dehydratase; COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (429 aa)
AGS69447.15-dehydro-4-deoxyglucarate dehydratase; COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (298 aa)
AGS69480.1Polyketide cyclase; COG1878 Predicted metal-dependent hydrolase. (256 aa)
AGS69819.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (285 aa)
AGS69878.1COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins. (382 aa)
AGS69935.1COG2902 NAD-specific glutamate dehydrogenase. (1645 aa)
hutICOG1228 Imidazolonepropionase and related amidohydrolases. (391 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (554 aa)
AGS70016.1COG2986 Histidine ammonia-lyase. (497 aa)
AGS70020.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
AGS70202.1Lipid-transfer protein; COG0183 Acetyl-CoA acetyltransferase. (384 aa)
AGS70213.1Hypothetical protein; COG0183 Acetyl-CoA acetyltransferase. (390 aa)
AGS70226.1Cyclase; COG1878 Predicted metal-dependent hydrolase. (311 aa)
murQN-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (307 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (141 aa)
AGS70483.1Valine dehydrogenase (NADP+); COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (365 aa)
AGS70551.1Lipid-transfer protein; COG0183 Acetyl-CoA acetyltransferase. (388 aa)
AGS70615.1Hypothetical protein. (423 aa)
kynATryptophan 23-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (282 aa)
kynUHydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (394 aa)
AGS70940.1COG0076 Glutamate decarboxylase and related PLP-dependent proteins; Belongs to the group II decarboxylase family. (468 aa)
AGS71052.1Cyclase; COG0009 Putative translation factor (SUA5). (321 aa)
AGS71126.1Fumarylacetoacetase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (405 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (483 aa)
hutHCOG2986 Histidine ammonia-lyase. (514 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
AGS71482.1D-amino acid deaminase; COG3616 Predicted amino acid aldolase or racemase. (425 aa)
AGS71673.1Hypothetical protein. (248 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (261 aa)
AGS71799.1Hypothetical protein; COG0438 Glycosyltransferase. (312 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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