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purQ purQ AGS70674.1 AGS70674.1 guaA guaA AGS71449.1 AGS71449.1 AGS71553.1 AGS71553.1 AGS71735.1 AGS71735.1 AGS72773.1 AGS72773.1 AGS72802.1 AGS72802.1 AGS72956.1 AGS72956.1 AGS67231.1 AGS67231.1 AGS67256.1 AGS67256.1 AGS67409.1 AGS67409.1 AGS67748.1 AGS67748.1 AGS67867.1 AGS67867.1 AGS68093.1 AGS68093.1 carA carA pdxT pdxT AGS68495.1 AGS68495.1 pyrG pyrG cobQ cobQ cobB cobB hisH hisH AGS69044.1 AGS69044.1 AGS69440.1 AGS69440.1 AGS69765.1 AGS69765.1 AGS69834.1 AGS69834.1 AGS69936.1 AGS69936.1 AGS70222.1 AGS70222.1 AGS72957.1 AGS72957.1 AGS73091.1 AGS73091.1 AGS73130.1 AGS73130.1 AGS73239.1 AGS73239.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (226 aa)
AGS70674.1COG0512 Anthranilate/para-aminobenzoate synthases component II. (212 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
AGS71449.1Hypothetical protein. (228 aa)
AGS71553.1Glutamine amidotransferase of anthranilate synthase; COG0512 Anthranilate/para-aminobenzoate synthases component II. (195 aa)
AGS71735.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (320 aa)
AGS72773.1Peptidase U61 LD-carboxypeptidase A; COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF. (307 aa)
AGS72802.1Protease; COG0693 Putative intracellular protease/amidase. (180 aa)
AGS72956.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (325 aa)
AGS67231.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (324 aa)
AGS67256.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (303 aa)
AGS67409.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (315 aa)
AGS67748.1Hydrolase. (484 aa)
AGS67867.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (318 aa)
AGS68093.1COG3442 Predicted glutamine amidotransferase. (242 aa)
carACOG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (385 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa)
AGS68495.1Peptidase C26; COG2071 Predicted glutamine amidotransferases. (220 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (549 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa)
AGS69044.1COG0147 Anthranilate/para-aminobenzoate synthases component I. (618 aa)
AGS69440.1COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF. (339 aa)
AGS69765.1Transcriptional activator AdpA; COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (401 aa)
AGS69834.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (332 aa)
AGS69936.1COG0693 Putative intracellular protease/amidase. (188 aa)
AGS70222.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (368 aa)
AGS72957.14-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme; COG0693 Putative intracellular protease/amidase. (214 aa)
AGS73091.1COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain. (332 aa)
AGS73130.1COG0693 Putative intracellular protease/amidase. (180 aa)
AGS73239.1DJ-1/PfpI-family transcriptional regulator; COG0693 Putative intracellular protease/amidase. (224 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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