(32 nodes) Benzoate degradation network (Streptomyces collinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGS67350.1	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit. (108 aa)
	AGS67355.1	COG1024 Enoyl-CoA hydratase/carnithine racemase. (248 aa)
	AGS67361.1	COG4829 Muconolactone delta-isomerase. (97 aa)
	AGS67463.1	COG1250 3-hydroxyacyl-CoA dehydrogenase. (300 aa)
	AGS67755.1	3-oxoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (259 aa)
	AGS67769.1	COG0183 Acetyl-CoA acetyltransferase. (388 aa)
	AGS67772.1	COG1024 Enoyl-CoA hydratase/carnithine racemase. (266 aa)
	AGS68199.1	3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
	AGS68463.1	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit. (148 aa)
	AGS68471.1	COG1250 3-hydroxyacyl-CoA dehydrogenase. (277 aa)
	AGS68638.1	COG1960 Acyl-CoA dehydrogenases. (396 aa)
	AGS68935.1	COG1024 Enoyl-CoA hydratase/carnithine racemase. (247 aa)
	AGS68939.1	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
	AGS69244.1	Lipid-transfer protein; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	AGS69271.1	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
	AGS70020.1	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	AGS70231.1	COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (505 aa)
	AGS70254.1	COG1024 Enoyl-CoA hydratase/carnithine racemase. (245 aa)
	AGS70692.1	COG1250 3-hydroxyacyl-CoA dehydrogenase. (504 aa)
	AGS71859.1	COG1250 3-hydroxyacyl-CoA dehydrogenase. (282 aa)
	AGS71873.1	Acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
	AGS72460.1	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	AGS72624.1	COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog. (60 aa)
	AGS72687.1	3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (430 aa)
	AGS72762.1	Oxidoreductase; COG1250 3-hydroxyacyl-CoA dehydrogenase. (604 aa)
	AGS72919.1	3-oxoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (373 aa)
	AGS72920.1	3-carboxy-cis,cis-muconate cycloisomerase; COG0015 Adenylosuccinate lyase. (452 aa)
	AGS72921.1	COG3485 Protocatechuate 3,4-dioxygenase beta subunit. (200 aa)
	AGS72922.1	COG3485 Protocatechuate 3,4-dioxygenase beta subunit. (261 aa)
	AGS72945.1	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
	AGS72946.1	Fatty acid oxidative multifunctional enzyme; COG1024 Enoyl-CoA hydratase/carnithine racemase. (727 aa)
	AGS73063.1	COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (254 aa)

Your Current Organism:

Streptomyces collinus

NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGS67350.1	AGS67361.1	B446_02590	B446_02645	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.	COG4829 Muconolactone delta-isomerase.	0.907
AGS67350.1	AGS67755.1	B446_02590	B446_04635	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.	3-oxoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.901
AGS67350.1	AGS72687.1	B446_02590	B446_29405	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.	3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.916
AGS67350.1	AGS72919.1	B446_02590	B446_30575	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.	3-oxoadipate enol-lactone hydrolase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.919
AGS67350.1	AGS72920.1	B446_02590	B446_30580	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.	3-carboxy-cis,cis-muconate cycloisomerase; COG0015 Adenylosuccinate lyase.	0.946
AGS67350.1	AGS72921.1	B446_02590	B446_30585	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.	COG3485 Protocatechuate 3,4-dioxygenase beta subunit.	0.462
AGS67350.1	AGS72922.1	B446_02590	B446_30590	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.	COG3485 Protocatechuate 3,4-dioxygenase beta subunit.	0.470
AGS67355.1	AGS67463.1	B446_02615	B446_03155	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1250 3-hydroxyacyl-CoA dehydrogenase.	0.875
AGS67355.1	AGS67769.1	B446_02615	B446_04705	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG0183 Acetyl-CoA acetyltransferase.	0.588
AGS67355.1	AGS68199.1	B446_02615	B446_06875	COG1024 Enoyl-CoA hydratase/carnithine racemase.	3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.548
AGS67355.1	AGS68471.1	B446_02615	B446_08235	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1250 3-hydroxyacyl-CoA dehydrogenase.	0.878
AGS67355.1	AGS68638.1	B446_02615	B446_09070	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1960 Acyl-CoA dehydrogenases.	0.948
AGS67355.1	AGS68935.1	B446_02615	B446_10565	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.724
AGS67355.1	AGS68939.1	B446_02615	B446_10585	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.548
AGS67355.1	AGS69244.1	B446_02615	B446_12110	COG1024 Enoyl-CoA hydratase/carnithine racemase.	Lipid-transfer protein; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.548
AGS67355.1	AGS69271.1	B446_02615	B446_12245	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.548
AGS67355.1	AGS70020.1	B446_02615	B446_16010	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.548
AGS67355.1	AGS70692.1	B446_02615	B446_19390	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1250 3-hydroxyacyl-CoA dehydrogenase.	0.874
AGS67355.1	AGS71859.1	B446_02615	B446_25240	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1250 3-hydroxyacyl-CoA dehydrogenase.	0.897
AGS67355.1	AGS71873.1	B446_02615	B446_25310	COG1024 Enoyl-CoA hydratase/carnithine racemase.	Acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.548