STRINGSTRING
AGS67176.1 AGS67176.1 AGS67257.1 AGS67257.1 AGS67466.1 AGS67466.1 AGS67769.1 AGS67769.1 AGS68023.1 AGS68023.1 AGS68381.1 AGS68381.1 AGS68596.1 AGS68596.1 AGS68922.1 AGS68922.1 AGS68939.1 AGS68939.1 AGS69107.1 AGS69107.1 AGS69110.1 AGS69110.1 AGS69257.1 AGS69257.1 AGS69271.1 AGS69271.1 aceE aceE AGS69380.1 AGS69380.1 leuA leuA AGS69455.1 AGS69455.1 AGS69623.1 AGS69623.1 AGS69748.1 AGS69748.1 AGS69896.1 AGS69896.1 AGS70020.1 AGS70020.1 ppc ppc AGS70218.1 AGS70218.1 AGS70695.1 AGS70695.1 AGS70696.1 AGS70696.1 AGS70697.1 AGS70697.1 AGS70707.1 AGS70707.1 AGS70708.1 AGS70708.1 AGS70709.1 AGS70709.1 acsA acsA AGS70938.1 AGS70938.1 AGS71141.1 AGS71141.1 AGS71142.1 AGS71142.1 mdh mdh AGS71421.1 AGS71421.1 AGS71429.1 AGS71429.1 pckG pckG fumC fumC AGS71534.1 AGS71534.1 AGS71768.1 AGS71768.1 AGS71873.1 AGS71873.1 AGS71893.1 AGS71893.1 ackA ackA AGS71895.1 AGS71895.1 AGS71997.1 AGS71997.1 AGS72052.1 AGS72052.1 AGS72427.1 AGS72427.1 AGS72591.1 AGS72591.1 AGS72628.1 AGS72628.1 AGS72660.1 AGS72660.1 AGS72805.1 AGS72805.1 AGS72945.1 AGS72945.1 AGS73325.1 AGS73325.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGS67176.1Beta-lactamase domain-containing protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (255 aa)
AGS67257.1Pyruvate dehydrogenase/oxidase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (585 aa)
AGS67466.1CoA-binding domain-containing protein; COG1042 Acyl-CoA synthetase (NDP forming). (684 aa)
AGS67769.1COG0183 Acetyl-CoA acetyltransferase. (388 aa)
AGS68023.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (507 aa)
AGS68381.1Hydrolase; COG0491 Zn-dependent hydrolases, including glyoxylases. (235 aa)
AGS68596.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (462 aa)
AGS68922.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
AGS68939.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
AGS69107.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
AGS69110.12-oxoacid dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AGS69257.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (483 aa)
AGS69271.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
aceEPyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (878 aa)
AGS69380.1Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (906 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
AGS69455.1Lyase; COG0346 Lactoylglutathione lyase and related lyases. (130 aa)
AGS69623.1COG0346 Lactoylglutathione lyase and related lyases. (148 aa)
AGS69748.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (641 aa)
AGS69896.1Malate oxidoreductase; COG0281 Malic enzyme. (471 aa)
AGS70020.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (910 aa)
AGS70218.1Hypothetical protein; COG1042 Acyl-CoA synthetase (NDP forming). (748 aa)
AGS70695.1COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (381 aa)
AGS70696.1COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (334 aa)
AGS70697.1Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (444 aa)
AGS70707.1COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (401 aa)
AGS70708.1COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (328 aa)
AGS70709.1Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (475 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AGS70938.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (486 aa)
AGS71141.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (353 aa)
AGS71142.1COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (642 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AGS71421.1COG1012 NAD-dependent aldehyde dehydrogenases. (478 aa)
AGS71429.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (590 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
AGS71534.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (554 aa)
AGS71768.1Malate oxidoreductase; COG0281 Malic enzyme. (406 aa)
AGS71873.1Acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
AGS71893.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (475 aa)
ackAAcetate kinase A/propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa)
AGS71895.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
AGS71997.1Alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)
AGS72052.1COG1254 Acylphosphatases. (93 aa)
AGS72427.1Hypothetical protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (455 aa)
AGS72591.1Pyruvate dehydrogenase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (580 aa)
AGS72628.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (557 aa)
AGS72660.1COG2225 Malate synthase; Belongs to the malate synthase family. (541 aa)
AGS72805.1COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (599 aa)
AGS72945.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
AGS73325.1COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases. (389 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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