STRINGSTRING
AGS67590.1 AGS67590.1 AGS67594.1 AGS67594.1 AGS67595.1 AGS67595.1 AGS67769.1 AGS67769.1 gcvP gcvP AGS68493.1 AGS68493.1 AGS68562.1 AGS68562.1 AGS68939.1 AGS68939.1 AGS69107.1 AGS69107.1 AGS69125.1 AGS69125.1 AGS69142.1 AGS69142.1 AGS69178.1 AGS69178.1 AGS69229.1 AGS69229.1 AGS69271.1 AGS69271.1 gltA gltA AGS69748.1 AGS69748.1 AGS69809.1 AGS69809.1 AGS69875.1 AGS69875.1 AGS70020.1 AGS70020.1 purU purU AGS70251.1 AGS70251.1 AGS70257.1 AGS70257.1 AGS70289.1 AGS70289.1 acsA acsA AGS71319.1 AGS71319.1 mdh mdh glyA-2 glyA-2 AGS71383.1 AGS71383.1 AGS71429.1 AGS71429.1 AGS71434.1 AGS71434.1 AGS71716.1 AGS71716.1 glyA-3 glyA-3 AGS71872.1 AGS71872.1 AGS71873.1 AGS71873.1 AGS71887.1 AGS71887.1 glyA glyA gcvH gcvH gcvT gcvT AGS72272.1 AGS72272.1 AGS72273.1 AGS72273.1 AGS72342.1 AGS72342.1 AGS72343.1 AGS72343.1 AGS72442.1 AGS72442.1 AGS72628.1 AGS72628.1 AGS72631.1 AGS72631.1 AGS72634.1 AGS72634.1 AGS72635.1 AGS72635.1 AGS72636.1 AGS72636.1 AGS72660.1 AGS72660.1 AGS72753.1 AGS72753.1 AGS72759.1 AGS72759.1 AGS72945.1 AGS72945.1 AGS73007.1 AGS73007.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGS67590.14Fe-4S ferredoxin; COG0437 Fe-S-cluster-containing hydrogenase components 1. (340 aa)
AGS67594.1Molybdopterin oxidoreductase Fe4S4 region; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing. (188 aa)
AGS67595.1Formate dehydrogenase subunit alpha; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (864 aa)
AGS67769.1COG0183 Acetyl-CoA acetyltransferase. (388 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
AGS68493.1COG0174 Glutamine synthetase. (454 aa)
AGS68562.1Hypothetical protein; COG2864 Cytochrome b subunit of formate dehydrogenase. (176 aa)
AGS68939.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
AGS69107.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
AGS69125.1COG0174 Glutamine synthetase. (469 aa)
AGS69142.1Glutamate--ammonia ligase; COG0174 Glutamine synthetase. (343 aa)
AGS69178.1COG0174 Glutamine synthetase. (453 aa)
AGS69229.12-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (230 aa)
AGS69271.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (429 aa)
AGS69748.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (641 aa)
AGS69809.1Hydrolase; COG0546 Predicted phosphatases. (239 aa)
AGS69875.1(S)-2-hydroxy-acid oxidase; COG0277 FAD/FMN-containing dehydrogenases. (457 aa)
AGS70020.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
AGS70251.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (366 aa)
AGS70257.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (613 aa)
AGS70289.1Hydrolase; COG0546 Predicted phosphatases. (211 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AGS71319.1COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding). (136 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (483 aa)
AGS71383.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (526 aa)
AGS71429.1COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (590 aa)
AGS71434.1COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (534 aa)
AGS71716.1Bromoperoxidase-catalase; COG0753 Catalase; Belongs to the catalase family. (483 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
AGS71872.1methylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. (146 aa)
AGS71873.1Acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
AGS71887.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (566 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
AGS72272.1COG0372 Citrate synthase. (423 aa)
AGS72273.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (388 aa)
AGS72342.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (724 aa)
AGS72343.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (602 aa)
AGS72442.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AGS72628.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (557 aa)
AGS72631.1COG3960 Glyoxylate carboligase; Belongs to the TPP enzyme family. (595 aa)
AGS72634.1COG0753 Catalase; Belongs to the catalase family. (485 aa)
AGS72635.12-hydroxy-3-oxopropionate reductase; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (297 aa)
AGS72636.1Oxidoreductase; COG3622 Hydroxypyruvate isomerase; Belongs to the hyi family. (273 aa)
AGS72660.1COG2225 Malate synthase; Belongs to the malate synthase family. (541 aa)
AGS72753.1COG1929 Glycerate kinase; Belongs to the glycerate kinase type-1 family. (378 aa)
AGS72759.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (664 aa)
AGS72945.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
AGS73007.1COG0174 Glutamine synthetase. (467 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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