STRINGSTRING
AGS66934.1 AGS66934.1 AGS67033.1 AGS67033.1 kirD kirD AGS68350.1 AGS68350.1 AGS68416.1 AGS68416.1 AGS68596.1 AGS68596.1 coaE coaE panB panB AGS69257.1 AGS69257.1 AGS69287.1 AGS69287.1 AGS69471.1 AGS69471.1 AGS69738.1 AGS69738.1 AGS70938.1 AGS70938.1 panC panC coaX coaX ilvD ilvD coaA coaA acpS acpS AGS71421.1 AGS71421.1 AGS71581.1 AGS71581.1 AGS71586.1 AGS71586.1 AGS71979.1 AGS71979.1 ilvH ilvH ilvC ilvC AGS71991.1 AGS71991.1 coaD coaD AGS72698.1 AGS72698.1 AGS72701.1 AGS72701.1 AGS72702.1 AGS72702.1 AGS73090.1 AGS73090.1 panD panD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AGS66934.14'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (232 aa)
AGS67033.1COG2091 Phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (205 aa)
kirDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (146 aa)
AGS68350.1Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
AGS68416.1Aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (273 aa)
AGS68596.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (462 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (288 aa)
AGS69257.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (483 aa)
AGS69287.1Oxidoreductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (299 aa)
AGS69471.1Putative 4'-phosphopantetheinyl transferase; COG2091 Phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (250 aa)
AGS69738.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (539 aa)
AGS70938.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (486 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (333 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (265 aa)
ilvDCOG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (617 aa)
coaACOG1072 Panthothenate kinase. (329 aa)
acpS4'-phosphopantetheinyl transferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (123 aa)
AGS71421.1COG1012 NAD-dependent aldehyde dehydrogenases. (478 aa)
AGS71581.1COG2091 Phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (272 aa)
AGS71586.1COG2091 Phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (246 aa)
AGS71979.1Acetolactate synthase 1 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (616 aa)
ilvHCOG0440 Acetolactate synthase, small (regulatory) subunit. (174 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
AGS71991.1COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (362 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
AGS72698.1Hydrolase; COG0388 Predicted amidohydrolase. (280 aa)
AGS72701.1Hydrolase; COG0388 Predicted amidohydrolase. (280 aa)
AGS72702.1Phenylhydantoinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. (467 aa)
AGS73090.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (591 aa)
panDAspartate alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (140 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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