STRINGSTRING
AGS67027.1 AGS67027.1 AGS68416.1 AGS68416.1 argD argD argB argB argJ argJ argC argC AGS68764.1 AGS68764.1 leuA leuA asd asd gltA gltA AGS69738.1 AGS69738.1 AGS70251.1 AGS70251.1 AGS70781.1 AGS70781.1 lysY lysY AGS70785.1 AGS70785.1 AGS70849.1 AGS70849.1 asd-2 asd-2 AGS70977.1 AGS70977.1 ilvD ilvD AGS71025.1 AGS71025.1 AGS71201.1 AGS71201.1 AGS71478.1 AGS71478.1 AGS71637.1 AGS71637.1 AGS71979.1 AGS71979.1 ilvH ilvH ilvC ilvC leuB leuB AGS71991.1 AGS71991.1 AGS71997.1 AGS71997.1 leuC leuC leuD leuD AGS72235.1 AGS72235.1 AGS72272.1 AGS72272.1 AGS72273.1 AGS72273.1 AGS72442.1 AGS72442.1 AGS72648.1 AGS72648.1 AGS73059.1 AGS73059.1 AGS73090.1 AGS73090.1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AGS67027.1Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (434 aa)
AGS68416.1Aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (273 aa)
argDCOG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa)
AGS68764.1Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (429 aa)
AGS69738.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (539 aa)
AGS70251.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (366 aa)
AGS70781.1Acetyl-lysine deacetylase; COG0548 Acetylglutamate kinase. (618 aa)
lysYPutative LysW-gamma-L-alpha-aminoadipyl-6-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (355 aa)
AGS70785.1Lysine biosynthesis protein LysX; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the RimK family. (289 aa)
AGS70849.1COG0527 Aspartokinases; Belongs to the aspartokinase family. (423 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (360 aa)
AGS70977.1COG1246 N-acetylglutamate synthase and related acetyltransferases. (177 aa)
ilvDCOG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (617 aa)
AGS71025.1Aminotransferase; COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (401 aa)
AGS71201.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (408 aa)
AGS71478.1Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (403 aa)
AGS71637.1Hypothetical protein; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (299 aa)
AGS71979.1Acetolactate synthase 1 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (616 aa)
ilvHCOG0440 Acetolactate synthase, small (regulatory) subunit. (174 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
AGS71991.1COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (362 aa)
AGS71997.1Alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
AGS72235.1Class III aminotransferase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (493 aa)
AGS72272.1COG0372 Citrate synthase. (423 aa)
AGS72273.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (388 aa)
AGS72442.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AGS72648.1Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (402 aa)
AGS73059.1COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
AGS73090.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (591 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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