(18 nodes) Mismatch repair network (Streptomyces collinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	AGS67314.1	Hypothetical protein. (112 aa)
	ligB	ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (512 aa)
	AGS68407.1	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (241 aa)
	AGS68723.1	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (318 aa)
	dnaE	COG0587 DNA polymerase III, alpha subunit. (1179 aa)
	AGS69469.1	COG1466 DNA polymerase III, delta subunit. (333 aa)
	AGS69668.1	COG0629 Single-stranded DNA-binding protein. (160 aa)
	dnaX	DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (762 aa)
	AGS70620.1	COG0629 Single-stranded DNA-binding protein. (196 aa)
	AGS70648.1	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
	AGS70919.1	DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication. (404 aa)
	AGS71316.1	COG0210 Superfamily I DNA and RNA helicases. (826 aa)
	xseB	Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (74 aa)
	xseA	Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (406 aa)
	AGS71694.1	COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1189 aa)
	AGS71698.1	COG0210 Superfamily I DNA and RNA helicases. (731 aa)
	ligA	NAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (731 aa)
	AGS72521.1	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (241 aa)

Your Current Organism:

Streptomyces collinus

NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGS67314.1	AGS69668.1	B446_02410	B446_14250	Hypothetical protein.	COG0629 Single-stranded DNA-binding protein.	0.900
AGS67314.1	AGS70620.1	B446_02410	B446_19030	Hypothetical protein.	COG0629 Single-stranded DNA-binding protein.	0.900
AGS68407.1	AGS68723.1	B446_07915	B446_09500	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.908
AGS68407.1	AGS69469.1	B446_07915	B446_13255	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG1466 DNA polymerase III, delta subunit.	0.944
AGS68407.1	AGS70648.1	B446_07915	B446_19170	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.958
AGS68407.1	AGS70919.1	B446_07915	B446_20535	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication.	0.914
AGS68407.1	AGS72521.1	B446_07915	B446_28575	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.911
AGS68407.1	dnaE	B446_07915	B446_10825	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0587 DNA polymerase III, alpha subunit.	0.955
AGS68407.1	dnaX	B446_07915	B446_18430	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.966
AGS68723.1	AGS68407.1	B446_09500	B446_07915	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.908
AGS68723.1	AGS69469.1	B446_09500	B446_13255	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG1466 DNA polymerase III, delta subunit.	0.944
AGS68723.1	AGS70648.1	B446_09500	B446_19170	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.958
AGS68723.1	AGS70919.1	B446_09500	B446_20535	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication.	0.914
AGS68723.1	AGS72521.1	B446_09500	B446_28575	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.916
AGS68723.1	dnaE	B446_09500	B446_10825	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0587 DNA polymerase III, alpha subunit.	0.955
AGS68723.1	dnaX	B446_09500	B446_18430	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.966
AGS69469.1	AGS68407.1	B446_13255	B446_07915	COG1466 DNA polymerase III, delta subunit.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.944
AGS69469.1	AGS68723.1	B446_13255	B446_09500	COG1466 DNA polymerase III, delta subunit.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.944
AGS69469.1	AGS69668.1	B446_13255	B446_14250	COG1466 DNA polymerase III, delta subunit.	COG0629 Single-stranded DNA-binding protein.	0.740
AGS69469.1	AGS70620.1	B446_13255	B446_19030	COG1466 DNA polymerase III, delta subunit.	COG0629 Single-stranded DNA-binding protein.	0.504