STRINGSTRING
rlmN rlmN CMV24_23305 CMV24_23305 moaA moaA nadA nadA queE queE rimO rimO CMV24_09960 CMV24_09960 edd edd RK21_03984 RK21_03984 hemN hemN RK21_00894 RK21_00894 sdhB sdhB CMV24_00320 CMV24_00320 CMV24_00185 CMV24_00185 CMV24_00065 CMV24_00065 RK21_03069 RK21_03069 nfuA nfuA RK21_03696 RK21_03696 leuC leuC nuoB nuoB CMV24_15915 CMV24_15915 RK21_00978 RK21_00978 nuoI nuoI RK21_03470 RK21_03470 ispH ispH GCA_000688275_04669 GCA_000688275_04669 RK21_03111 RK21_03111 CMV24_15415 CMV24_15415 CMV24_20050 CMV24_20050 GCA_000688275_00187 GCA_000688275_00187 CMV24_20045 CMV24_20045 RK21_05186 RK21_05186 pqqE pqqE bioB bioB RK21_03318 RK21_03318 CMV24_12040 CMV24_12040 CMV24_16990 CMV24_16990 lipA-2 lipA-2 fdxH fdxH RK21_04525 RK21_04525 CMV24_20520 CMV24_20520 RK21_01662 RK21_01662 rlmD rlmD ttcA ttcA acnB acnB RK21_04771 RK21_04771 CMV24_11215 CMV24_11215 CMV24_11270 CMV24_11270 RK21_05706 RK21_05706 CMV24_01375 CMV24_01375 queG queG thiC thiC nth nth dinG dinG CMV24_24490 CMV24_24490 GCA_000688275_01625 GCA_000688275_01625 lipA lipA ispG ispG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rlmNUnannotated protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (381 aa)
CMV24_23305Unannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (776 aa)
moaAUnannotated protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (334 aa)
nadAUnannotated protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (352 aa)
queEUnannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa)
rimOUnannotated protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (443 aa)
CMV24_09960Unannotated protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
eddUnannotated protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa)
RK21_03984Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
hemNUnannotated protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa)
RK21_00894Unannotated protein; Accepts electrons from ETF and reduces ubiquinone. (554 aa)
sdhBUnannotated protein. (234 aa)
CMV24_00320Unannotated protein. (472 aa)
CMV24_00185Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (391 aa)
CMV24_00065Unannotated protein. (83 aa)
RK21_03069Unannotated protein. (550 aa)
nfuAUnannotated protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (194 aa)
RK21_03696Unannotated protein; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (641 aa)
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa)
nuoBUnannotated protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (225 aa)
CMV24_15915Unannotated protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (454 aa)
RK21_00978Unannotated protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (904 aa)
nuoIUnannotated protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (182 aa)
RK21_03470Unannotated protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (322 aa)
ispHUnannotated protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (315 aa)
GCA_000688275_04669Unannotated protein. (614 aa)
RK21_03111Unannotated protein. (885 aa)
CMV24_15415Unannotated protein; Reduction of activated sulfate into sulfite. (244 aa)
CMV24_20050Unannotated protein. (956 aa)
GCA_000688275_00187Unannotated protein. (832 aa)
CMV24_20045Unannotated protein. (519 aa)
RK21_05186Unannotated protein. (351 aa)
pqqEUnannotated protein; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (382 aa)
bioBUnannotated protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (352 aa)
RK21_03318Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa)
CMV24_12040Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
CMV24_16990Unannotated protein. (411 aa)
lipA-2Unannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa)
fdxHUnannotated protein; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (316 aa)
RK21_04525Unannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (809 aa)
CMV24_20520Unannotated protein. (196 aa)
RK21_01662Unannotated protein. (284 aa)
rlmDUnannotated protein; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (452 aa)
ttcAUnannotated protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (274 aa)
acnBUnannotated protein; Belongs to the aconitase/IPM isomerase family. (697 aa)
RK21_04771Unannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (781 aa)
CMV24_11215Unannotated protein; Adenine glycosylase active on G-A mispairs. (355 aa)
CMV24_11270Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
RK21_05706Unannotated protein. (438 aa)
CMV24_01375Unannotated protein. (766 aa)
queGUnannotated protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (354 aa)
thiCUnannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (628 aa)
nthUnannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)
dinGUnannotated protein; DNA-dependent ATPase and 5'-3' DNA helicase. (714 aa)
CMV24_24490Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
GCA_000688275_01625Unannotated protein. (252 aa)
lipAUnannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (332 aa)
ispGUnannotated protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (369 aa)
Your Current Organism:
Pseudomonas plecoglossicida
NCBI taxonomy Id: 1215115
Other names: P. plecoglossicida NBRC 103162 = DSM 15088, Pseudomonas plecoglossicida DSM 15088, Pseudomonas plecoglossicida DSM 15088 = NBRC 103162, Pseudomonas plecoglossicida NBRC 103162, Pseudomonas plecoglossicida NBRC 103162 = DSM 15088
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