STRINGSTRING
ERG6 ERG6 NMT1_2 NMT1_2 EYZ11_001115 EYZ11_001115 EYZ11_001501 EYZ11_001501 EYZ11_002212 EYZ11_002212 EYZ11_003125 EYZ11_003125 EYZ11_001833 EYZ11_001833 EYZ11_001910 EYZ11_001910 EYZ11_001856 EYZ11_001856 EYZ11_004176 EYZ11_004176 ERG24_2 ERG24_2 EYZ11_003533 EYZ11_003533 THI4 THI4 EYZ11_002786 EYZ11_002786 EYZ11_002845 EYZ11_002845 EYZ11_007601 EYZ11_007601 EYZ11_005605 EYZ11_005605 EYZ11_006116 EYZ11_006116 EYZ11_007136 EYZ11_007136 ERG12_1 ERG12_1 MSMO1_2 MSMO1_2 EYZ11_007422 EYZ11_007422 EYZ11_007486 EYZ11_007486 EYZ11_007409 EYZ11_007409 EYZ11_007393 EYZ11_007393 EYZ11_007641 EYZ11_007641 EYZ11_007963 EYZ11_007963 EYZ11_008326 EYZ11_008326 EYZ11_008909 EYZ11_008909 EYZ11_008906 EYZ11_008906 EYZ11_009751 EYZ11_009751 NPS6 NPS6 EYZ11_009339 EYZ11_009339 EYZ11_009345 EYZ11_009345 EYZ11_009351 EYZ11_009351 EYZ11_011558 EYZ11_011558 EYZ11_009498 EYZ11_009498 RER2 RER2 EYZ11_009890 EYZ11_009890 ERG3 ERG3 ERG26_1 ERG26_1 EYZ11_010412 EYZ11_010412 EYZ11_011505 EYZ11_011505 LCB1 LCB1 EYZ11_011374 EYZ11_011374 EYZ11_011556 EYZ11_011556 EYZ11_011560 EYZ11_011560 EYZ11_012096 EYZ11_012096 PDC1 PDC1 EYZ11_012058 EYZ11_012058 EYZ11_012345 EYZ11_012345 EYZ11_012390 EYZ11_012390 EYZ11_012449 EYZ11_012449 EYZ11_012448 EYZ11_012448 EYZ11_000949 EYZ11_000949 EYZ11_000184 EYZ11_000184 EYZ11_011011 EYZ11_011011 EYZ11_004487 EYZ11_004487 GCH1 GCH1 EYZ11_004656 EYZ11_004656 ERG13 ERG13 EYZ11_004134 EYZ11_004134 EYZ11_004397 EYZ11_004397 SC5DL SC5DL ERG4_4 ERG4_4 EYZ11_002985 EYZ11_002985 EYZ11_003539 EYZ11_003539 EYZ11_003448 EYZ11_003448 EYZ11_003061 EYZ11_003061 EYZ11_003129 EYZ11_003129 MCR1 MCR1 EYZ11_004651 EYZ11_004651 EYZ11_004812 EYZ11_004812 EYZ11_004654 EYZ11_004654 EYZ11_007163 EYZ11_007163 EYZ11_005200 EYZ11_005200 EYZ11_005220 EYZ11_005220 TAL1 TAL1 EYZ11_000969 EYZ11_000969 EYZ11_003550 EYZ11_003550 ERG12_2 ERG12_2 EYZ11_005184 EYZ11_005184 ERG4_2 ERG4_2 ERG27 ERG27 ERG1 ERG1 EYZ11_000111 EYZ11_000111 INO1_1 INO1_1 ERG9 ERG9 ERG24_1 ERG24_1 ERG8 ERG8 cprA cprA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ERG6Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (377 aa)
NMT1_2Glycylpeptide N-tetradecanoyltransferase. (342 aa)
EYZ11_001115Uncharacterized protein; Belongs to the cytochrome P450 family. (533 aa)
EYZ11_001501Uncharacterized protein. (106 aa)
EYZ11_002212Neutral ceramidase. (761 aa)
EYZ11_003125Uncharacterized protein. (298 aa)
EYZ11_001833Uncharacterized protein. (207 aa)
EYZ11_001910S5A_REDUCTASE domain-containing protein. (292 aa)
EYZ11_001856Uncharacterized protein. (185 aa)
EYZ11_004176NMO domain-containing protein. (344 aa)
ERG24_2Erg24, C-14 sterol reductase. (499 aa)
EYZ11_003533Uncharacterized protein. (453 aa)
THI4Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (330 aa)
EYZ11_002786Uncharacterized protein. (523 aa)
EYZ11_002845Fe-ADH domain-containing protein. (495 aa)
EYZ11_007601Uncharacterized protein. (474 aa)
EYZ11_005605FSH1 domain-containing protein. (274 aa)
EYZ11_006116Uncharacterized protein. (536 aa)
EYZ11_007136Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa)
ERG12_1Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (439 aa)
MSMO1_2Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (289 aa)
EYZ11_007422MFS domain-containing protein. (384 aa)
EYZ11_007486Fungal_trans domain-containing protein. (1153 aa)
EYZ11_007409Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (293 aa)
EYZ11_007393Thiolase_N domain-containing protein. (64 aa)
EYZ11_0076413-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (436 aa)
EYZ11_007963Kinase; Belongs to the inositol phosphokinase (IPK) family. (1377 aa)
EYZ11_008326Uncharacterized protein. (134 aa)
EYZ11_008909Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (254 aa)
EYZ11_008906AlcB domain-containing protein. (449 aa)
EYZ11_009751Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (428 aa)
NPS6Nonribosomal peptide synthetases (NRPS). (2085 aa)
EYZ11_009339Zn(2)-C6 fungal-type domain-containing protein. (545 aa)
EYZ11_009345MFS domain-containing protein. (541 aa)
EYZ11_009351Uncharacterized protein. (590 aa)
EYZ11_011558Epimerase domain-containing protein. (166 aa)
EYZ11_009498DAGKc domain-containing protein. (500 aa)
RER2Alkyl transferase; Belongs to the UPP synthase family. (395 aa)
EYZ11_009890Uncharacterized protein. (632 aa)
ERG3C-5 sterol desaturase; Belongs to the sterol desaturase family. (347 aa)
ERG26_1Erg26, C-3 sterol dehydrogenase. (412 aa)
EYZ11_010412Uncharacterized protein. (543 aa)
EYZ11_011505Uncharacterized protein. (460 aa)
LCB1Serine palmitoyltransferase component. (504 aa)
EYZ11_011374TMP-TENI domain-containing protein. (519 aa)
EYZ11_011556Uncharacterized protein. (578 aa)
EYZ11_0115603Beta_HSD domain-containing protein. (189 aa)
EYZ11_012096Uncharacterized protein. (255 aa)
PDC1Pyruvate decarboxylase 1. (576 aa)
EYZ11_012058Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (513 aa)
EYZ11_012345Uncharacterized protein. (147 aa)
EYZ11_012390EXPERA domain-containing protein. (235 aa)
EYZ11_012449Uncharacterized protein. (176 aa)
EYZ11_012448Uncharacterized protein. (169 aa)
EYZ11_000949AMP-binding domain-containing protein. (360 aa)
EYZ11_000184Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (245 aa)
EYZ11_011011Uncharacterized protein. (736 aa)
EYZ11_004487EXPERA domain-containing protein. (232 aa)
GCH1GTP cyclohydrolase 1. (334 aa)
EYZ11_004656Uncharacterized protein. (103 aa)
ERG133-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (458 aa)
EYZ11_004134Uncharacterized protein. (459 aa)
EYZ11_004397Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
SC5DLSterol-C5-desaturase; Belongs to the sterol desaturase family. (342 aa)
ERG4_4C-24(28) sterol reductase. (481 aa)
EYZ11_002985Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (362 aa)
EYZ11_003539Uncharacterized protein. (509 aa)
EYZ11_003448Uncharacterized protein. (148 aa)
EYZ11_003061Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (476 aa)
EYZ11_003129FAD-binding FR-type domain-containing protein. (310 aa)
MCR1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (322 aa)
EYZ11_004651Inos-1-P_synth domain-containing protein. (149 aa)
EYZ11_004812DUF2236 domain-containing protein. (290 aa)
EYZ11_004654Uncharacterized protein. (114 aa)
EYZ11_0071633-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (440 aa)
EYZ11_005200Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (559 aa)
EYZ11_005220Kinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
TAL1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (324 aa)
EYZ11_000969Uncharacterized protein. (196 aa)
EYZ11_003550Uncharacterized protein. (231 aa)
ERG12_2Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (532 aa)
EYZ11_005184Uncharacterized protein. (79 aa)
ERG4_2C-24(28) sterol reductase. (422 aa)
ERG273-keto-steroid reductase. (444 aa)
ERG1Squalene epoxidase. (487 aa)
EYZ11_000111Uncharacterized protein. (216 aa)
INO1_1Myo-inositol-1-phosphate synthase. (534 aa)
ERG9Terpene cyclase. (471 aa)
ERG24_1Erg24, C-14 sterol reductase. (483 aa)
ERG8Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (482 aa)
cprANADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (695 aa)
Your Current Organism:
Aspergillus tanneri
NCBI taxonomy Id: 1220188
Other names: A. tanneri, ATCC MYA-4905, Aspergillus tanneri Kwon-Chung, Sugui & S. W. Peterson 2012, NIH1004, NRRL 62425, NRRL 62426, NRRL 63426
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