(46 nodes) Methane metabolism network (Aspergillus tanneri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	EYZ11_009303	Uncharacterized protein. (470 aa)
	FBP1	Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family. (354 aa)
	EYZ11_012485	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (283 aa)
	EYZ11_010583	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (237 aa)
	EYZ11_011802	ADH_N domain-containing protein. (82 aa)
	EYZ11_011800	ADH_zinc_N domain-containing protein. (255 aa)
	EYZ11_012061	PNPLA domain-containing protein. (561 aa)
	EYZ11_012882	Uncharacterized protein. (438 aa)
	EYZ11_012916	PNPLA domain-containing protein. (398 aa)
	EYZ11_012917	Uncharacterized protein. (416 aa)
	EYZ11_013314	GMC_OxRdtase_N domain-containing protein. (602 aa)
	EYZ11_012989	PNPLA domain-containing protein. (133 aa)
	EYZ11_005583	Uncharacterized protein. (1207 aa)
	EYZ11_005261	Uncharacterized protein. (472 aa)
	EYZ11_007723	Uncharacterized protein. (316 aa)
	EYZ11_008317	Aminotran_5 domain-containing protein. (385 aa)
	EYZ11_010048	Probable acetate kinase. (399 aa)
	EYZ11_010621	Uncharacterized protein. (889 aa)
	EYZ11_011804	Putative glutathione-dependent formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (191 aa)
	EYZ11_000043	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa)
	FLD1_1	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (379 aa)
	EYZ11_000099	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (286 aa)
	EYZ11_000478	Uncharacterized protein. (95 aa)
	FBA1	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (360 aa)
	SHM2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	EYZ11_001935	Uncharacterized protein. (519 aa)
	EYZ11_002348	Uncharacterized protein. (658 aa)
	EYZ11_002559	GFA domain-containing protein. (147 aa)
	EYZ11_002662	TRANSKETOLASE_1 domain-containing protein. (729 aa)
	EYZ11_003733	Uncharacterized protein. (589 aa)
	EYZ11_003119	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (360 aa)
	EYZ11_003301	Uncharacterized protein. (91 aa)
	ACS1	Acetyl-coenzyme A synthetase. (666 aa)
	EYZ11_003492	GFA domain-containing protein. (123 aa)
	PFK1	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (786 aa)
	EYZ11_003790	Uncharacterized protein. (976 aa)
	EYZ11_006944	PNPLA domain-containing protein. (861 aa)
	EYZ11_006011	Uncharacterized protein. (483 aa)
	EYZ11_005998	Uncharacterized protein. (209 aa)
	EYZ11_007877	PFK domain-containing protein. (285 aa)
	EYZ11_008377	PNPLA domain-containing protein. (583 aa)
	EYZ11_009308	Uncharacterized protein. (200 aa)
	EYZ11_008508	Uncharacterized protein. (122 aa)
	EYZ11_008713	Uncharacterized protein. (406 aa)
	EYZ11_009298	PNPLA domain-containing protein. (600 aa)
	EYZ11_009297	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (462 aa)

Your Current Organism:

Aspergillus tanneri

NCBI taxonomy Id: 1220188
Other names: A. tanneri, ATCC MYA-4905, Aspergillus tanneri Kwon-Chung, Sugui & S. W. Peterson 2012, NIH1004, NRRL 62425, NRRL 62426, NRRL 63426

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACS1	EYZ11_010048	A0A4S3JNF6	A0A4V3UNA7	Acetyl-coenzyme A synthetase.	Probable acetate kinase.	0.897
ACS1	EYZ11_012485	A0A4S3JNF6	A0A4S3J5I7	Acetyl-coenzyme A synthetase.	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	0.722
EYZ11_000043	EYZ11_001935	A0A4S3JY48	A0A4S3JRY9	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein.	0.593
EYZ11_000043	EYZ11_002348	A0A4S3JY48	A0A4S3JR56	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein.	0.593
EYZ11_000043	EYZ11_003119	A0A4S3JY48	A0A4S3JPA4	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.545
EYZ11_000043	EYZ11_005261	A0A4S3JY48	A0A4V3UPP7	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein.	0.737
EYZ11_000043	EYZ11_008317	A0A4S3JY48	A0A4V3UNS2	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Aminotran_5 domain-containing protein.	0.932
EYZ11_000043	EYZ11_008713	A0A4S3JY48	A0A4S3J9X6	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein.	0.947
EYZ11_000043	EYZ11_009297	A0A4S3JY48	A0A4S3J891	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.741
EYZ11_000043	SHM2	A0A4S3JY48	A0A4S3JTM6	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.741
EYZ11_000099	EYZ11_000478	A0A4S3JXT5	A0A4S3JX22	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein.	0.585
EYZ11_000099	EYZ11_002559	A0A4S3JXT5	A0A4S3JQJ4	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	GFA domain-containing protein.	0.585
EYZ11_000099	EYZ11_003119	A0A4S3JXT5	A0A4S3JPA4	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.941
EYZ11_000099	EYZ11_003492	A0A4S3JXT5	A0A4S3JN22	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	GFA domain-containing protein.	0.585
EYZ11_000099	EYZ11_007723	A0A4S3JXT5	A0A4V3UNW2	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein.	0.934
EYZ11_000099	EYZ11_008508	A0A4S3JXT5	A0A4S3JA89	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein.	0.585
EYZ11_000099	EYZ11_011800	A0A4S3JXT5	A0A4S3J1V6	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	ADH_zinc_N domain-containing protein.	0.996
EYZ11_000099	EYZ11_011802	A0A4S3JXT5	A0A4S3J2F6	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	ADH_N domain-containing protein.	0.983
EYZ11_000099	EYZ11_011804	A0A4S3JXT5	A0A4V3UMV3	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Putative glutathione-dependent formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family.	0.900
EYZ11_000099	FLD1_1	A0A4S3JXT5	A0A4S3JY22	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.996

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