(110 nodes) Regulation of cell cycle process network (Cyphellophora europaea)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W2S1R4_9EURO	Uncharacterized protein. (350 aa)
	W2S229_9EURO	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (530 aa)
	W2S252_9EURO	Protein kinase domain-containing protein. (547 aa)
	W2S283_9EURO	WD_REPEATS_REGION domain-containing protein. (606 aa)
	W2S296_9EURO	Protein kinase domain-containing protein. (670 aa)
	W2S2J4_9EURO	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2956 aa)
	W2S2T4_9EURO	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (444 aa)
	W2S372_9EURO	Uncharacterized protein. (567 aa)
	W2S3A0_9EURO	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (546 aa)
	W2S3J2_9EURO	Rab-GAP TBC domain-containing protein. (408 aa)
	W2S3X4_9EURO	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (182 aa)
	W2S454_9EURO	Protein kinase domain-containing protein. (1491 aa)
	W2S4C9_9EURO	Uncharacterized protein. (1014 aa)
	W2S528_9EURO	TYR_PHOSPHATASE_2 domain-containing protein. (681 aa)
	W2S5S0_9EURO	ANAPC5 domain-containing protein. (765 aa)
	W2S626_9EURO	PARP-type domain-containing protein. (322 aa)
	W2S6B0_9EURO	BRCT domain-containing protein. (216 aa)
	W2S6W9_9EURO	HORMA domain-containing protein. (704 aa)
	W2S728_9EURO	Zn(2)-C6 fungal-type domain-containing protein. (724 aa)
	W2S7S7_9EURO	TPR_REGION domain-containing protein. (758 aa)
	W2S8J2_9EURO	Uncharacterized protein. (432 aa)
	W2S8L2_9EURO	Uncharacterized protein. (943 aa)
	W2S8P0_9EURO	Uncharacterized protein. (861 aa)
	W2S8U3_9EURO	Septum-promoting GTP-binding protein 1. (284 aa)
	W2S987_9EURO	Uncharacterized protein; Involved in DNA replication and cell separation. Belongs to the SDS23 family. (488 aa)
	W2S9B1_9EURO	BRCT domain-containing protein. (1345 aa)
	W2S9P9_9EURO	Uncharacterized protein. (1095 aa)
	W2SAA6_9EURO	RNA-dependent RNA polymerase. (1165 aa)
	W2SAY0_9EURO	Uncharacterized protein. (621 aa)
	W2SB56_9EURO	ERCC4 domain-containing protein. (637 aa)
	W2SBF4_9EURO	Structural maintenance of chromosomes protein. (1177 aa)
	W2SBI6_9EURO	Protein kinase domain-containing protein. (556 aa)
	W2SBU0_9EURO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (405 aa)
	W2SBX9_9EURO	HORMA domain-containing protein. (225 aa)
	W2SCF6_9EURO	Uncharacterized protein. (763 aa)
	W2SCJ7_9EURO	Uncharacterized protein. (1294 aa)
	W2SCL8_9EURO	RNA-dependent RNA polymerase. (1344 aa)
	W2SCQ3_9EURO	Uncharacterized protein. (365 aa)
	W2SCW7_9EURO	Uncharacterized protein. (472 aa)
	W2SE74_9EURO	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (453 aa)
	W2SED6_9EURO	Uncharacterized protein. (347 aa)
	W2SEG7_9EURO	BTB domain-containing protein. (264 aa)
	W2SEQ0_9EURO	SMK-1 domain-containing protein. (918 aa)
	W2SES1_9EURO	Uncharacterized protein. (77 aa)
	W2SEZ3_9EURO	Uncharacterized protein. (440 aa)
	W2SFP1_9EURO	ERCC4 domain-containing protein. (595 aa)
	W2SGM7_9EURO	Uncharacterized protein. (782 aa)
	W2RIZ6_9EURO	TPR_REGION domain-containing protein. (423 aa)
	W2RJB5_9EURO	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (647 aa)
	W2RJE0_9EURO	Uncharacterized protein. (831 aa)
	W2RJM7_9EURO	Uncharacterized protein. (721 aa)
	W2RK08_9EURO	Spindle pole body component. (861 aa)
	W2RKE7_9EURO	Protein kinase domain-containing protein. (818 aa)
	W2RL64_9EURO	Uncharacterized protein. (236 aa)
	W2RMG6_9EURO	Serine/threonine-protein kinase. (1012 aa)
	W2RMM3_9EURO	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1034 aa)
	W2RMS8_9EURO	Uncharacterized protein. (1037 aa)
	W2RMV2_9EURO	Uncharacterized protein. (108 aa)
	W2RNS3_9EURO	WD_REPEATS_REGION domain-containing protein. (707 aa)
	W2RNW1_9EURO	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (320 aa)
	W2RNY4_9EURO	Protein kinase domain-containing protein. (1128 aa)
	W2RP01_9EURO	RING-type domain-containing protein. (127 aa)
	W2RQ24_9EURO	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (407 aa)
	W2RQ78_9EURO	Cell division control protein; Belongs to the CDC6/cdc18 family. (608 aa)
	W2RQA7_9EURO	Uncharacterized protein. (827 aa)
	W2RR15_9EURO	Uncharacterized protein. (164 aa)
	W2RR80_9EURO	FHA domain-containing protein. (902 aa)
	W2RRB3_9EURO	Importin N-terminal domain-containing protein. (1099 aa)
	W2RRK5_9EURO	WD_REPEATS_REGION domain-containing protein. (624 aa)
	W2RRL8_9EURO	Uncharacterized protein. (676 aa)
	W2RS19_9EURO	AAA domain-containing protein. (858 aa)
	W2RS25_9EURO	Spc7 domain-containing protein. (1751 aa)
	W2RS39_9EURO	CULLIN_2 domain-containing protein; Belongs to the cullin family. (706 aa)
	W2RSN6_9EURO	Zds_C domain-containing protein. (880 aa)
	W2RSP1_9EURO	Uncharacterized protein. (813 aa)
	W2RSQ2_9EURO	Uncharacterized protein. (525 aa)
	W2RT00_9EURO	Uncharacterized protein. (306 aa)
	W2RTQ6_9EURO	Cell division control protein 42. (193 aa)
	W2RTQ8_9EURO	Non-specific serine/threonine protein kinase. (868 aa)
	W2RTX8_9EURO	Uncharacterized protein. (584 aa)
	W2RUL2_9EURO	Uncharacterized protein. (685 aa)
	W2RUV0_9EURO	RRM domain-containing protein. (709 aa)
	W2RUY5_9EURO	Rhodanese domain-containing protein. (552 aa)
	W2RV54_9EURO	Serine/threonine-protein kinase pef1; Belongs to the protein kinase superfamily. (416 aa)
	W2RVK4_9EURO	Cyclin-dependent kinase 1. (327 aa)
	W2RVS9_9EURO	Uncharacterized protein. (1522 aa)
	W2RVX5_9EURO	Checkpoint protein; Belongs to the HUS1 family. (353 aa)
	W2RW31_9EURO	Uncharacterized protein. (705 aa)
	W2RWC3_9EURO	WAPL domain-containing protein. (891 aa)
	W2RWK6_9EURO	GTP-binding protein rhoC. (280 aa)
	W2RWR3_9EURO	Uncharacterized protein. (1769 aa)
	W2RXJ4_9EURO	Uncharacterized protein. (750 aa)
	W2RXL8_9EURO	Uncharacterized protein. (663 aa)
	W2RXP8_9EURO	Non-specific serine/threonine protein kinase. (870 aa)
	W2RXW0_9EURO	MRC1 domain-containing protein. (1380 aa)
	W2RXX7_9EURO	Uncharacterized protein. (359 aa)
	W2RY00_9EURO	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (416 aa)
	W2RY52_9EURO	WD_REPEATS_REGION domain-containing protein. (583 aa)
	W2RYS0_9EURO	Uncharacterized protein. (153 aa)
	W2RYU8_9EURO	Protein kinase domain-containing protein. (694 aa)
	W2RZ75_9EURO	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (752 aa)
	W2RZB4_9EURO	Uncharacterized protein. (938 aa)
	W2RZK6_9EURO	Serine/threonine-protein phosphatase. (404 aa)
	W2S032_9EURO	Uncharacterized protein. (1958 aa)
	W2S0R5_9EURO	mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (181 aa)
	W2S0V4_9EURO	Uncharacterized protein. (497 aa)
	W2S190_9EURO	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (531 aa)
	W2S1J3_9EURO	Uncharacterized protein. (1057 aa)
	W2S1Q3_9EURO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
	W2S1U5_9EURO	Serine/threonine-protein phosphatase. (455 aa)

Your Current Organism:

Cyphellophora europaea

NCBI taxonomy Id: 1220924
Other names: C. europaea CBS 101466, Cyphellophora europaea CBS 101466, Phialophora europaea CBS 101466

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
W2RIZ6_9EURO	W2RXL8_9EURO	W2RIZ6	W2RXL8	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.633
W2RJB5_9EURO	W2RMG6_9EURO	W2RJB5	W2RMG6	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein kinase.	0.723
W2RJB5_9EURO	W2RNS3_9EURO	W2RJB5	W2RNS3	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	WD_REPEATS_REGION domain-containing protein.	0.638
W2RJB5_9EURO	W2RNW1_9EURO	W2RJB5	W2RNW1	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.864
W2RJB5_9EURO	W2RNY4_9EURO	W2RJB5	W2RNY4	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Protein kinase domain-containing protein.	0.478
W2RJB5_9EURO	W2RQ24_9EURO	W2RJB5	W2RQ24	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.724
W2RJB5_9EURO	W2RR15_9EURO	W2RJB5	W2RR15	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.600
W2RJB5_9EURO	W2RTQ8_9EURO	W2RJB5	W2RTQ8	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Non-specific serine/threonine protein kinase.	0.404
W2RJB5_9EURO	W2RUY5_9EURO	W2RJB5	W2RUY5	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Rhodanese domain-containing protein.	0.608
W2RJB5_9EURO	W2RV54_9EURO	W2RJB5	W2RV54	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein kinase pef1; Belongs to the protein kinase superfamily.	0.690
W2RJB5_9EURO	W2RVK4_9EURO	W2RJB5	W2RVK4	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Cyclin-dependent kinase 1.	0.690
W2RJB5_9EURO	W2RXP8_9EURO	W2RJB5	W2RXP8	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Non-specific serine/threonine protein kinase.	0.404
W2RJB5_9EURO	W2RY00_9EURO	W2RJB5	W2RY00	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.612
W2RJB5_9EURO	W2RY52_9EURO	W2RJB5	W2RY52	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	WD_REPEATS_REGION domain-containing protein.	0.638
W2RJB5_9EURO	W2RZK6_9EURO	W2RJB5	W2RZK6	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase.	0.904
W2RJB5_9EURO	W2S1R4_9EURO	W2RJB5	W2S1R4	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.631
W2RJB5_9EURO	W2S1U5_9EURO	W2RJB5	W2S1U5	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase.	0.904
W2RJB5_9EURO	W2S229_9EURO	W2RJB5	W2S229	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.973
W2RJB5_9EURO	W2S283_9EURO	W2RJB5	W2S283	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	WD_REPEATS_REGION domain-containing protein.	0.638
W2RJB5_9EURO	W2S528_9EURO	W2RJB5	W2S528	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	TYR_PHOSPHATASE_2 domain-containing protein.	0.419