STRINGSTRING
EMF02601.1 EMF02601.1 EMF02655.1 EMF02655.1 EMF02691.1 EMF02691.1 EMF02142.1 EMF02142.1 EMF02153.1 EMF02153.1 EMF01849.1 EMF01849.1 EMF01687.1 EMF01687.1 EMF01703.1 EMF01703.1 rplA rplA EMF01002.1 EMF01002.1 rpsD rpsD EMF00601.1 EMF00601.1 EMF00605.1 EMF00605.1 infC infC lepA lepA rsfS rsfS EME99967.1 EME99967.1 tsf tsf EME99590.1 EME99590.1 infA infA hpf hpf EME99216.1 EME99216.1 EME98832.1 EME98832.1 efp efp EME98663.1 EME98663.1 sti sti EME98108.1 EME98108.1 EME98116.1 EME98116.1 fusA fusA tuf tuf EME97894.1 EME97894.1 EME97789.1 EME97789.1 EME97672.1 EME97672.1 rplM rplM prfB prfB EME97228.1 EME97228.1 EME97162.1 EME97162.1 infB infB prfA prfA infA-2 infA-2 EME96764.1 EME96764.1 EME96466.1 EME96466.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EMF02601.1COG0480 Translation elongation factors (GTPases). (138 aa)
EMF02655.1Hypothetical protein. (709 aa)
EMF02691.1Hypothetical protein. (183 aa)
EMF02142.1ABC transporter; COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (534 aa)
EMF02153.1COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (544 aa)
EMF01849.1Hypothetical protein. (187 aa)
EMF01687.1Hypothetical protein. (208 aa)
EMF01703.1Elongation factor Tu; COG0050 GTPases - translation elongation factors. (450 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (238 aa)
EMF01002.1GTP-binding protein TypA or BipA; COG1217 Predicted membrane GTPase involved in stress response. (635 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (204 aa)
EMF00601.1Roadblock/LC7 family protein; COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid. (140 aa)
EMF00605.1Roadblock/LC7 family protein; COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid. (140 aa)
infCTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (189 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (620 aa)
rsfSIojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (146 aa)
EME99967.1Proteinase inhibitor I4 serpin; COG4826 Serine protease inhibitor; Belongs to the serpin family. (402 aa)
tsfElongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (278 aa)
EME99590.1Hypothetical protein. (388 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa)
hpfHypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (228 aa)
EME99216.1COG3462 Predicted membrane protein. (93 aa)
EME98832.1Hypothetical protein. (352 aa)
efpElongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (188 aa)
EME98663.1Proteinase inhibitor I16 subtilisin-type inhibitor. (131 aa)
stiProtease inhibitor protein; Strong inhibitor of bacterial serine proteases such as subtilisin. (148 aa)
EME98108.1Hypothetical protein. (441 aa)
EME98116.1COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (554 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (706 aa)
tufElongation factor Tu1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa)
EME97894.1Small GTP-binding protein; COG0480 Translation elongation factors (GTPases). (713 aa)
EME97789.1Elongation factor Tu; COG0050 GTPases - translation elongation factors. (200 aa)
EME97672.1Putative ABC transporter ATP-binding protein; COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (539 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa)
prfBPeptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (368 aa)
EME97228.1COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (550 aa)
EME97162.1Hypothetical protein. (272 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (613 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (358 aa)
infA-2Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (74 aa)
EME96764.1COG1186 Protein chain release factor B. (142 aa)
EME96466.1Putative ABC transporter ATP-binding protein; COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (532 aa)
Your Current Organism:
Streptomyces mobaraensis
NCBI taxonomy Id: 1223523
Other names: S. mobaraensis NBRC 13819 = DSM 40847, Streptomyces mobaraensis ATCC 29032, Streptomyces mobaraensis DSM 40847, Streptomyces mobaraensis DSM 40847 = NBRC 13819, Streptomyces mobaraensis IFO 13819, Streptomyces mobaraensis NBRC 13819, Streptomyces mobaraensis NBRC 13819 = DSM 40847, Streptomyces mobaraensis NRRL B-3729
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