| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NMB1886 | metH | NMB1886 | NMB0944 | Conserved hypothetical protein; Identified by similarity to EGAD:91612; match to protein family HMM PF01590. | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation. | 0.900 |
| NMB1886 | metK | NMB1886 | NMB1799 | Conserved hypothetical protein; Identified by similarity to EGAD:91612; match to protein family HMM PF01590. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
| cysE | cysK | NMB0560 | NMB0763 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.999 |
| cysE | cysS | NMB0560 | NMB2083 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | cysteinyl-tRNA synthetase; Identified by similarity to EGAD:17646; match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.950 |
| cysE | ilvA | NMB0560 | NMB0878 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.805 |
| cysE | metM | NMB0560 | NMB1228 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Homoserine dehydrogenase; Identified by similarity to EGAD:6746; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.813 |
| cysE | sdaA | NMB0560 | NMB0211 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | L-serine dehydratase; Identified by similarity to GP:3402236; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.911 |
| cysE | serB | NMB0560 | NMB0981 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Phosphoserine phosphatase; Identified by similarity to EGAD:8936; match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.823 |
| cysE | thrB | NMB0560 | NMB2029 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Homoserine kinase; Identified by similarity to GP:3089616; match to protein family HMM PF01636; match to protein family HMM TIGR00938; Belongs to the pseudomonas-type ThrB family. | 0.802 |
| cysK | cysE | NMB0763 | NMB0560 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | 0.999 |
| cysK | cysS | NMB0763 | NMB2083 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | cysteinyl-tRNA synthetase; Identified by similarity to EGAD:17646; match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.800 |
| cysK | luxS | NMB0763 | NMB1981 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Conserved hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.884 |
| cysK | metB | NMB0763 | NMB0802 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine gamma-synthase; Identified by similarity to EGAD:109991; match to protein family HMM PF01053. | 0.976 |
| cysK | metH | NMB0763 | NMB0944 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation. | 0.860 |
| cysK | metZ | NMB0763 | NMB1609 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Trans-sulfuration enzyme family protein; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.972 |
| cysK | pfs | NMB0763 | NMB0767 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.475 |
| cysK | serC | NMB0763 | NMB1640 | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.931 |
| cysS | cysE | NMB2083 | NMB0560 | cysteinyl-tRNA synthetase; Identified by similarity to EGAD:17646; match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | 0.950 |
| cysS | cysK | NMB2083 | NMB0763 | cysteinyl-tRNA synthetase; Identified by similarity to EGAD:17646; match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | Cysteine synthase; Identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.800 |
| ilvA | cysE | NMB0878 | NMB0560 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | 0.805 |