STRINGSTRING
NMB1829 NMB1829 NMB2134 NMB2134 NMB2091 NMB2091 porB porB NMB1989 NMB1989 frpB frpB NMB1963 NMB1963 NMB1949 NMB1949 NMB1948 NMB1948 mlp mlp NMB1882 NMB1882 NMB1881 NMB1881 NMB1880 NMB1880 pilQ pilQ pilN pilN pilM pilM tonB tonB NMB1674 NMB1674 NMB1672 NMB1672 hmbR hmbR NMB1628 NMB1628 NMB1548 NMB1548 lbpA lbpA NMB1497 NMB1497 NMB1466 NMB1466 NMB1462 NMB1462 NMB1440 NMB1440 porA porA prc prc eno eno NMB1279 NMB1279 NMB1238 NMB1238 NMB1164 NMB1164 NMB1162 NMB1162 NMB1126 NMB1126 NMB1124 NMB1124 NMB1085 NMB1085 ggt ggt NMB0987 NMB0987 NMB0964 NMB0964 NMB0946 NMB0946 NMB0928 NMB0928 NMB0877 NMB0877 lolB lolB NMB0749 NMB0749 lnt lnt lptE lptE comL comL lolA lolA nqrE nqrE dnaK dnaK NMB0464 NMB0464 tbp1 tbp1 amiC amiC lptA lptA NMB0354 NMB0354 NMB0346 NMB0346 NMB0345 NMB0345 NMB0293 NMB0293 lptD lptD rlpA rlpA bamE bamE omp85 omp85 NMB0181 NMB0181 NMB0088 NMB0088 ctrB ctrB ctrA ctrA NMB0041 NMB0041 NMB0033 NMB0033
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NMB1829TonB-dependent receptor; Identified by similarity to EGAD:8251; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783. (708 aa)
NMB2134Conserved hypothetical protein; Identified by similarity to EGAD:24660; match to protein family HMM PF01103. (635 aa)
NMB2091Putative hemolysin; Identified by similarity to EGAD:28637; match to protein family HMM PF04972. (202 aa)
porBMajor outer membrane protein PIB; Serves as a slightly cation selective porin; Belongs to the Gram-negative porin family. (331 aa)
NMB1989iron(III) ABC transporter, periplasmic binding protein; Identified by similarity to EGAD:108974; match to protein family HMM PF01497. (321 aa)
frpBIron-regulated outer membrane protein FrpB; Identified by similarity to EGAD:133971; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783. (714 aa)
NMB1963Conserved hypothetical protein; Identified by similarity to EGAD:163193; match to protein family HMM PF05494. (196 aa)
NMB1949Putative soluble lytic murein transglycosylase; Identified by similarity to EGAD:23218; match to protein family HMM PF01464. (616 aa)
NMB1948ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. (245 aa)
mlpLipoprotein; Identified by similarity to EGAD:40759; match to protein family HMM PF04355. (171 aa)
NMB1882TonB-dependent receptor; Identified by similarity to EGAD:8251; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783. (725 aa)
NMB1881Conserved hypothetical protein; Identified by similarity to EGAD:108081; match to protein family HMM PF07883. (107 aa)
NMB1880Putative ABC transporter, periplasmic solute-binding protein; Identified by similarity to EGAD:108974; match to protein family HMM PF01497. (321 aa)
pilQpilQ protein; Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA (By similarity); Belongs to the bacterial secretin family. PilQ subfamily. (769 aa)
pilNpilN protein; Identified by similarity to EGAD:151888; match to protein family HMM PF05137. (199 aa)
pilMpilM protein; Identified by similarity to EGAD:151887; match to protein family HMM TIGR01175. (371 aa)
tonBTonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence. (280 aa)
NMB1674GDSL lipase family protein; Identified by similarity to EGAD:18113; match to protein family HMM PF00657. (213 aa)
NMB1672Conserved hypothetical protein; Identified by similarity to EGAD:91019; match to protein family HMM PF03886. (172 aa)
hmbRHemoglobin receptor; Identified by similarity to EGAD:131251; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01786. (791 aa)
NMB1628Putative tspB protein; Identified by similarity to GP:3758871; match to protein family HMM PF05616. (517 aa)
NMB1548Putative tspB protein; Identified by similarity to GP:3758871; match to protein family HMM PF05616. (548 aa)
lbpALactoferrin-binding protein A; Unknown. May be an iron-siderophore receptor. (943 aa)
NMB1497TonB-dependent receptor; Probable receptor, TonB-dependent. (921 aa)
NMB1466Conserved hypothetical protein; Identified by similarity to EGAD:28010; match to protein family HMM PF04575. (243 aa)
NMB1462Putative transglycosylase; Identified by similarity to EGAD:107330; match to protein family HMM PF01464. (207 aa)
NMB1440Hypothetical protein; Identified by Glimmer2; putative. (237 aa)
porAOuter membrane protein PorA; Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity. (392 aa)
prcCarboxy-terminal peptidase; Identified by similarity to GP:555748; match to protein family HMM PF00595; match to protein family HMM PF03572; match to protein family HMM TIGR00225; Belongs to the peptidase S41A family. (494 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
NMB1279Putative membrane-bound lytic murein transglycosylase B; Identified by similarity to EGAD:31033; match to protein family HMM TIGR02282. (369 aa)
NMB1238Peptidyl-prolyl cis-trans isomerase-related protein; Identified by similarity to EGAD:91215. (512 aa)
NMB1164Hypothetical protein; Identified by Glimmer2; putative. (223 aa)
NMB1162Hypothetical protein; Identified by Glimmer2; putative. (215 aa)
NMB1126Hypothetical protein; Identified by Glimmer2; putative. (223 aa)
NMB1124Hypothetical protein; Identified by Glimmer2; putative. (215 aa)
NMB1085Putative N-acetylmuramoyl-L-alanine amidase; Identified by similarity to EGAD:21606. (181 aa)
ggtGamma-glutamyltranspeptidase; Identified by similarity to EGAD:161107; match to protein family HMM PF01019; match to protein family HMM TIGR00066. (606 aa)
NMB0987Putative N-acetylmuramoyl-L-alanine amidase; Identified by similarity to EGAD:21606. (181 aa)
NMB0964TonB-dependent receptor; Probable receptor, TonB-dependent. (758 aa)
NMB0946Identified by similarity to EGAD:48455; match to protein family HMM PF00462; match to protein family HMM PF00578; match to protein family HMM TIGR02190. (245 aa)
NMB0928Hypothetical protein; Identified by Glimmer2; putative. (398 aa)
NMB0877Penicillin-binding protein; Identified by similarity to EGAD:10529; match to protein family HMM PF00768; match to protein family HMM PF07943; Belongs to the peptidase S11 family. (389 aa)
lolBPutative outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (193 aa)
NMB0749Penicillin-binding protein 4; Identified by similarity to EGAD:8088; match to protein family HMM PF00768; Belongs to the peptidase S11 family. (312 aa)
lntPutative apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (524 aa)
lptEPutative rare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family. (159 aa)
comLCompetence lipoprotein ComL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Required for efficient transformation of Neisseria meningitidis by species-related DNA; Belongs to the BamD family. (267 aa)
lolAOuter membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). (207 aa)
nqrENa(+)-translocating NADH-quinone reductase, subunit E; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family. (197 aa)
dnaKdnaK protein; Acts as a chaperone. (642 aa)
NMB0464Putative phospholipase A1; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. (382 aa)
tbp1Transferrin-binding protein 1; Acts as a transferrin receptor and is required for transferrin utilization; Belongs to the TonB-dependent receptor family. (915 aa)
amiCN-acetylmuramoyl-L-alanine amidase; Cell-wall hydrolase involved in septum cleavage during cell division; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. (416 aa)
lptAConserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. (176 aa)
NMB0354Hypothetical protein; Identified by Glimmer2; putative. (193 aa)
NMB0346Hypothetical protein; Identified by Glimmer2; putative. (252 aa)
NMB0345Putative cell-binding factor; Identified by similarity to EGAD:12394. (288 aa)
NMB0293Putative TonB-dependent receptor; Identified by similarity to EGAD:48295; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783. (703 aa)
lptDPutative organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Belongs to the LptD family. (758 aa)
rlpAConserved hypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (239 aa)
bamEPutative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (125 aa)
omp85Outer membrane protein Omp85; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane; Belongs to the BamA family. (797 aa)
NMB0181Putative outer membrane protein OmpH; Identified by similarity to EGAD:24192; match to protein family HMM PF03938; Belongs to the skp family. (166 aa)
NMB0088Putative outer membrane protein P1; Identified by similarity to EGAD:16317; match to protein family HMM PF03349; Belongs to the OmpP1/FadL family. (466 aa)
ctrBCapsule polysaccharide export inner-membrane protein CtrB; May form an ATP-driven capsule polysaccharide export apparatus, in association with the CtrC and CtrD proteins; Belongs to the BexC/CtrB/KpsE family. (387 aa)
ctrACapsule polysaccharide export outer membrane protein CtrA; Involved in transport of capsular polysaccharides to the cell surface. May function as a membrane anchor for capsular polysaccharides. Possible porin properties; Belongs to the BexD/CtrA/VexA family. (391 aa)
NMB0041ABC transporter, periplasmic solute-binding protein; Identified by similarity to EGAD:159451; match to protein family HMM PF01547; match to protein family HMM TIGR01254. (333 aa)
NMB0033Putative membrane-bound lytic murein transglycosylase A; Identified by similarity to GP:974447; match to protein family HMM PF03562; match to protein family HMM PF06725. (441 aa)
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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