STRINGSTRING
ruvC ruvC SFP75122.1 SFP75122.1 SFP76613.1 SFP76613.1 topA topA SFP80271.1 SFP80271.1 SFP80892.1 SFP80892.1 SFP80910.1 SFP80910.1 ligA ligA SFP87744.1 SFP87744.1 SFP90733.1 SFP90733.1 SFP91479.1 SFP91479.1 dnaG dnaG SFP96288.1 SFP96288.1 SFP96315.1 SFP96315.1 SFQ00026.1 SFQ00026.1 sbcD sbcD SFQ01148.1 SFQ01148.1 SFQ01510.1 SFQ01510.1 recR recR SFQ18940.1 SFQ18940.1 ruvB ruvB recA recA uvrB uvrB ruvA ruvA SFQ26056.1 SFQ26056.1 radA radA SFQ27559.1 SFQ27559.1 polA polA SFQ28798.1 SFQ28798.1 recF recF SFQ29760.1 SFQ29760.1 recX recX SFQ33034.1 SFQ33034.1 uvrC uvrC SFQ36787.1 SFQ36787.1 SFQ37354.1 SFQ37354.1 mfd mfd mutS mutS recG recG SFQ40102.1 SFQ40102.1 SFQ40625.1 SFQ40625.1 SFQ41689.1 SFQ41689.1 mutL mutL SFQ47654.1 SFQ47654.1 SFQ48590.1 SFQ48590.1 SFQ51052.1 SFQ51052.1 SFQ51763.1 SFQ51763.1 mutS2 mutS2 SFQ52880.1 SFQ52880.1 SFQ53323.1 SFQ53323.1 SFQ53792.1 SFQ53792.1 recO recO dnaX dnaX SFQ68636.1 SFQ68636.1 SFQ69200.1 SFQ69200.1 SFQ73041.1 SFQ73041.1 priA priA dnaA dnaA SFQ76487.1 SFQ76487.1 SFQ76697.1 SFQ76697.1 SFQ76705.1 SFQ76705.1 SFQ79990.1 SFQ79990.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ruvCHolliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (213 aa)
SFP75122.1DNA topoisomerase-3. (855 aa)
SFP76613.1DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (827 aa)
SFP80271.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (731 aa)
SFP80892.1tRNA1Val (adenine37-N6)-methyltransferase; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). (246 aa)
SFP80910.1RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (156 aa)
ligADNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (701 aa)
SFP87744.1DNA processing protein. (375 aa)
SFP90733.1DNA polymerase III, delta subunit. (395 aa)
SFP91479.1DNA polymerase-3 subunit epsilon. (494 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (698 aa)
SFP96288.1Protein of unknown function. (140 aa)
SFP96315.1Putative DNA-binding domain-containing protein. (208 aa)
SFQ00026.1Competence protein ComEC. (758 aa)
sbcDExodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (419 aa)
SFQ01148.1Exonuclease SbcC. (1238 aa)
SFQ01510.1Fic/DOC family protein. (328 aa)
recRDNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (204 aa)
SFQ18940.1DNA polymerase-3 subunit delta'. (381 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (352 aa)
recARecombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (371 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa)
ruvAHolliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
SFQ26056.1Helicase conserved C-terminal domain-containing protein. (992 aa)
radADNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (465 aa)
SFQ27559.1Hypothetical protein. (204 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (963 aa)
SFQ28798.1comF family protein. (233 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (370 aa)
SFQ29760.1Exonuclease RecJ. (579 aa)
recXRegulatory protein; Modulates RecA activity; Belongs to the RecX family. (168 aa)
SFQ33034.1Putative endonuclease; Belongs to the UPF0102 family. (119 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (611 aa)
SFQ36787.1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (847 aa)
SFQ37354.1ATP-dependent DNA helicase RecQ. (734 aa)
mfdTranscription-repair coupling factor (superfamily II helicase); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1137 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (937 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (698 aa)
SFQ40102.1Single-strand binding protein. (144 aa)
SFQ40625.1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (946 aa)
SFQ41689.1Magnesium chelatase family protein. (511 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (685 aa)
SFQ47654.1DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. (558 aa)
SFQ48590.1Helicase conserved C-terminal domain-containing protein. (941 aa)
SFQ51052.1Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (537 aa)
SFQ51763.1DNA polymerase-3 subunit epsilon. (240 aa)
mutS2DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (814 aa)
SFQ52880.1ATP-dependent DNA helicase RecQ. (908 aa)
SFQ53323.1MutS domain V. (533 aa)
SFQ53792.1ATP-dependent DNA helicase RecQ. (645 aa)
recODNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (240 aa)
dnaXDNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (685 aa)
SFQ68636.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (681 aa)
SFQ69200.1DNA polymerase III, alpha subunit. (1237 aa)
SFQ73041.1DNA polymerase-3 subunit epsilon. (203 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (847 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (518 aa)
SFQ76487.1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1009 aa)
SFQ76697.1Hypothetical protein. (324 aa)
SFQ76705.1Putative TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (330 aa)
SFQ79990.1Hypothetical protein. (1107 aa)
Your Current Organism:
Siccationidurans arizonensis
NCBI taxonomy Id: 1227077
Other names: DSM 17870, Hymenobacter arizonensis, Hymenobacter arizonensis Reddy and Garcia-Pichel 2013, Hymenobacter sp. OR362-8, JCM 13504, S. arizonensis, strain OR362-8
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