STRINGSTRING
SFQ69318.1 SFQ69318.1 SFP69692.1 SFP69692.1 ruvC ruvC SFP72223.1 SFP72223.1 SFP75781.1 SFP75781.1 ligA ligA SFP95597.1 SFP95597.1 SFQ01449.1 SFQ01449.1 recR recR dinB dinB ruvB ruvB recA recA uvrB uvrB SFQ23863.1 SFQ23863.1 SFQ25293.1 SFQ25293.1 ruvA ruvA radA radA SFQ27460.1 SFQ27460.1 polA polA SFQ28861.1 SFQ28861.1 recF recF SFQ29760.1 SFQ29760.1 uvrC uvrC SFQ36787.1 SFQ36787.1 SFQ37354.1 SFQ37354.1 mfd mfd mutS mutS recG recG SFQ40124.1 SFQ40124.1 nth nth SFQ40534.1 SFQ40534.1 SFQ40625.1 SFQ40625.1 mutL mutL SFQ47654.1 SFQ47654.1 SFQ48455.1 SFQ48455.1 SFQ48468.1 SFQ48468.1 SFQ49285.1 SFQ49285.1 SFQ49519.1 SFQ49519.1 SFQ49968.1 SFQ49968.1 SFQ50828.1 SFQ50828.1 SFQ52756.1 SFQ52756.1 mutS2 mutS2 SFQ52880.1 SFQ52880.1 SFQ53323.1 SFQ53323.1 SFQ53356.1 SFQ53356.1 SFQ53369.1 SFQ53369.1 recO recO nfi nfi SFQ58546.1 SFQ58546.1 SFQ60101.1 SFQ60101.1 SFQ60156.1 SFQ60156.1 SFQ60625.1 SFQ60625.1 SFQ61295.1 SFQ61295.1 SFQ61312.1 SFQ61312.1 SFQ69033.1 SFQ69033.1 ung ung SFQ72551.1 SFQ72551.1 SFQ75942.1 SFQ75942.1 SFQ76487.1 SFQ76487.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFQ69318.1DNA polymerase (family 10). (578 aa)
SFP69692.1Spore photoproduct lyase. (373 aa)
ruvCHolliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (213 aa)
SFP72223.1DNA-3-methyladenine glycosylase II. (210 aa)
SFP75781.1PD-(D/E)XK nuclease superfamily protein. (997 aa)
ligADNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (701 aa)
SFP95597.1NIPSNAP protein. (229 aa)
SFQ01449.1Putative ATPase. (442 aa)
recRDNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (204 aa)
dinBDNA polymerase-4; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (359 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (352 aa)
recARecombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (371 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa)
SFQ23863.1DNA-3-methyladenine glycosylase; Belongs to the DNA glycosylase MPG family. (205 aa)
SFQ25293.1Cell surface protein SprA. (2464 aa)
ruvAHolliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
radADNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (465 aa)
SFQ27460.1Alkylated DNA repair dioxygenase AlkB. (203 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (963 aa)
SFQ28861.1Exodeoxyribonuclease-3. (264 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (370 aa)
SFQ29760.1Exonuclease RecJ. (579 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (611 aa)
SFQ36787.1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (847 aa)
SFQ37354.1ATP-dependent DNA helicase RecQ. (734 aa)
mfdTranscription-repair coupling factor (superfamily II helicase); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1137 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (937 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (698 aa)
SFQ40124.1A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. (360 aa)
nthDNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (225 aa)
SFQ40534.1Competence protein ComEA helix-hairpin-helix repeat region. (334 aa)
SFQ40625.1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (946 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (685 aa)
SFQ47654.1DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. (558 aa)
SFQ48455.1DNA polymerase V; Belongs to the peptidase S24 family. (157 aa)
SFQ48468.1DNA polymerase V. (431 aa)
SFQ49285.1Hypothetical protein. (172 aa)
SFQ49519.1DNA-3-methyladenine glycosylase I. (206 aa)
SFQ49968.1methylated-DNA-protein-cysteine methyltransferase related protein. (118 aa)
SFQ50828.1DNA-(apurinic or apyrimidinic site) lyase. (279 aa)
SFQ52756.1TIGR02757 family protein. (274 aa)
mutS2DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (814 aa)
SFQ52880.1ATP-dependent DNA helicase RecQ. (908 aa)
SFQ53323.1MutS domain V. (533 aa)
SFQ53356.1SOS response UmuD protein. Serine peptidase. MEROPS family S24; Belongs to the peptidase S24 family. (151 aa)
SFQ53369.1DNA polymerase V. (443 aa)
recODNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (240 aa)
nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (229 aa)
SFQ58546.1UV-damage endonuclease. (333 aa)
SFQ60101.1Putative DNA modification/repair radical SAM protein. (422 aa)
SFQ60156.1Probable DNA metabolism protein. (306 aa)
SFQ60625.1Endonuclease-3. (268 aa)
SFQ61295.1Hypothetical protein. (310 aa)
SFQ61312.1Helix-hairpin-helix motif-containing protein. (728 aa)
SFQ69033.1Endonuclease-3. (259 aa)
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (220 aa)
SFQ72551.1ApaG protein. (128 aa)
SFQ75942.1methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (163 aa)
SFQ76487.1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1009 aa)
Your Current Organism:
Siccationidurans arizonensis
NCBI taxonomy Id: 1227077
Other names: DSM 17870, Hymenobacter arizonensis, Hymenobacter arizonensis Reddy and Garcia-Pichel 2013, Hymenobacter sp. OR362-8, JCM 13504, S. arizonensis, strain OR362-8
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