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| | C444_00310 | COG1499 NMD protein affecting ribosome stability and mRNA decay. (381 aa) |
| | rrmJ | 23S rRNA methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (263 aa) |
| | C444_00662 | SSU processome protein Utp24; COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily. (124 aa) |
| | eif2g | Translation initiation factor IF-2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (409 aa) |
| | rpl40e | COG1552 Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa) |
| | trm1 | N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (367 aa) |
| | rps27ae | COG1998 Ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (44 aa) |
| | rps24e | COG2004 Ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (102 aa) |
| | C444_02151 | COG1094 Predicted RNA-binding protein (contains KH domains). (182 aa) |
| | C444_02166 | COG1718 Serine/threonine protein kinase involved in cell cycle control. (311 aa) |
| | eif1a | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (95 aa) |
| | C444_02321 | COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; Belongs to the SUI1 family. (97 aa) |
| | rps12P | 30S ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa) |
| | rps7 | 30S ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (206 aa) |
| | fusA | Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (728 aa) |
| | tuf | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (421 aa) |
| | rps10p | 30S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa) |
| | rps6e | COG2125 Ribosomal protein S6E (S10); Belongs to the eukaryotic ribosomal protein eS6 family. (129 aa) |
| | C444_03047 | COG1881 Phospholipid-binding protein. (190 aa) |
| | rpl10e | COG0197 Ribosomal protein L16/L10E; Belongs to the universal ribosomal protein uL16 family. (177 aa) |
| | C444_03402 | GTP-binding protein; COG1084 Predicted GTPase. (331 aa) |
| | C444_03822 | ATPase RIL; COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog. (609 aa) |
| | rpl15e | COG1632 Ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (196 aa) |
| | C444_04082 | COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain. (302 aa) |
| | C444_04087 | Hypothetical protein. (410 aa) |
| | eif5a | Translation initiation factor IF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (126 aa) |
| | C444_04961 | Thermosome subunit alpha; COG0459 Chaperonin GroEL (HSP60 family); Belongs to the TCP-1 chaperonin family. (519 aa) |
| | rpl37ae | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. (102 aa) |
| | C444_05826 | Putative GTP-binding protein/protein synthesis factor; COG5258 GTPase. (543 aa) |
| | rpl3p | 50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (338 aa) |
| | rpl4lp | 50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (246 aa) |
| | rpl23 | 50S ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (85 aa) |
| | rpl2p | 50S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (240 aa) |
| | rps19p | 30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (140 aa) |
| | rpl22p | 50S ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (155 aa) |
| | rps3p | 30S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (310 aa) |
| | rpl29 | COG0255 Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (71 aa) |
| | rps17p | 30S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (112 aa) |
| | rpl14p | 50S ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa) |
| | rpl24p | 50S ribosomal protein L24P; Located at the polypeptide exit tunnel on the outside of the subunit. (120 aa) |
| | rps4e | COG1471 Ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (234 aa) |
| | rpl5p | 50S ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (177 aa) |
| | rps14 | 30S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (61 aa) |
| | rps8p | 30S ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6p | 50S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa) |
| | rpl32e | 50S ribosomal protein L32e; COG0468 RecA/RadA recombinase; Belongs to the eukaryotic ribosomal protein eL32 family. (241 aa) |
| | rpl19e | 50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (149 aa) |
| | rpl18p | 50S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (139 aa) |
| | rps5p | 30S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (212 aa) |
| | rpl30p | COG1841 Ribosomal protein L30/L7E. (154 aa) |
| | rpl15p | 50S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (165 aa) |
| | rps8e | COG2007 Ribosomal protein S8E. (123 aa) |
| | rps3ae | COG1890 Ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (213 aa) |
| | rps15p | COG0184 Ribosomal protein S15P/S13E. (156 aa) |
| | rpl12p | 50S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (115 aa) |
| | rplP0 | Acidic ribosomal protein P0; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (348 aa) |
| | rpl1P | 50S ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa) |
| | rpl11p | 50S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (162 aa) |
| | C444_06656 | Small GTP-binding protein; COG1163 Predicted GTPase. (369 aa) |
| | dphB | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (259 aa) |
| | eif1a-2 | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (87 aa) |
| | C444_09300 | RNA-associated protein; COG1500 Predicted exosome subunit. (242 aa) |
| | eif2b | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (134 aa) |
| | C444_10179 | Histone acetyltransferase, ELP3 family protein; COG1243 Histone acetyltransferase. (551 aa) |
| | pelA | Cell division protein pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (355 aa) |
| | flpA | Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (210 aa) |
| | C444_10694 | Nucleolar protein-like protein; COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog. (280 aa) |
| | C444_10744 | COG1881 Phospholipid-binding protein. (151 aa) |
| | rpl37e | 50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (57 aa) |
| | rps10 | 30S ribosomal protein S10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (110 aa) |
| | C444_11742 | ATP binding protein; COG2102 Predicted ATPases of PP-loop superfamily. (239 aa) |
| | C444_11762 | COG0144 tRNA and rRNA cytosine-C5-methylases; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (303 aa) |
| | C444_12062 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (348 aa) |
| | C444_13207 | COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation. (59 aa) |
| | ef1B | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa) |
| | rpl21e | COG2139 Ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa) |
| | C444_13612 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (327 aa) |
| | proS | prolyl-tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (484 aa) |
| | C444_13767 | COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain. (203 aa) |
| | ndk | Mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (154 aa) |
| | rpl24e | 50S ribosomal protein L24e/unknown domain fusion protein; Binds to the 23S rRNA. (110 aa) |
| | rps28e | COG2053 Ribosomal protein S28E/S33; Belongs to the eukaryotic ribosomal protein eS28 family. (75 aa) |
| | rpl7ae | 50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (120 aa) |
| | rps2P | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (272 aa) |
| | rps9p | COG0103 Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (132 aa) |
| | rpl13p | 50S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (145 aa) |
| | rpl18e | COG1727 Ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (116 aa) |
| | rps11p | 30S ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rps4p | 30S ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (171 aa) |
| | rps13p | 30S ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (177 aa) |
| | rps17E | COG1383 Ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (63 aa) |
| | srp19 | Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (92 aa) |
| | rpl44e | 50S ribosomal protein L44e; Binds to the 23S rRNA. (92 aa) |
| | rps27e | COG2051 Ribosomal protein S27E. (57 aa) |
| | eif2a | Translation initiation factor IF-2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (266 aa) |
| | thrS | COG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (642 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (298 aa) |
| | C444_15673 | UDP-glucose 4-epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases. (291 aa) |
| | C444_15883 | Hypothetical protein; COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module. (152 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (601 aa) |
| | rps19e | 30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (153 aa) |
| | prf1 | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (418 aa) |
| | srp54 | Signal recognition particle protein Srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (470 aa) |
| | ftsY | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (428 aa) |
| | rplX | COG2157 Ribosomal protein L20A (L18A). (57 aa) |
| | eif6 | Translation initiation factor IF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (221 aa) |
| | rpl31e | COG2097 Ribosomal protein L31E; Belongs to the ribosomal protein L31e family. (92 aa) |
| | rpl39e | COG2167 Ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (50 aa) |
| | C444_20521 | COG1383 Ribosomal protein S17E. (65 aa) |
| | secY-2 | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (489 aa) |
