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pyrE pyrE C464_01943 C464_01943 C464_01963 C464_01963 C464_02138 C464_02138 C464_02143 C464_02143 purL purL carB carB C464_03155 C464_03155 C464_03160 C464_03160 udk udk tdk tdk C464_03367 C464_03367 tmk tmk pyrF pyrF C464_04718 C464_04718 folD folD C464_04938 C464_04938 thyA thyA pyrC pyrC C464_05715 C464_05715 C464_06370 C464_06370 C464_06728 C464_06728 adk adk purK purK purE purE C464_07615 C464_07615 C464_07710 C464_07710 C464_07715 C464_07715 C464_07950 C464_07950 C464_07955 C464_07955 guaB guaB purM purM C464_09677 C464_09677 C464_10009 C464_10009 C464_10104 C464_10104 C464_10518 C464_10518 purA purA C464_10853 C464_10853 purS purS purQ purQ surE surE purD purD pyrI pyrI pyrB pyrB C464_11915 C464_11915 C464_11930 C464_11930 purF purF C464_12470 C464_12470 C464_12475 C464_12475 C464_13585 C464_13585 guaAA guaAA C464_14190 C464_14190 C464_14230 C464_14230 surE-2 surE-2 pyrH pyrH C464_14480 C464_14480 guaAB guaAB upp upp purT purT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (184 aa)
C464_01943COG0262 Dihydrofolate reductase. (187 aa)
C464_01963COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. (237 aa)
C464_02138Hypothetical protein. (122 aa)
C464_02143COG0695 Glutaredoxin and related proteins. (84 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (753 aa)
carBCOG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1073 aa)
C464_03155Hypothetical protein. (72 aa)
C464_03160COG2019 Archaeal adenylate kinase. (184 aa)
udkCOG0572 Uridine kinase. (232 aa)
tdkCOG1435 Thymidine kinase. (213 aa)
C464_03367COG0151 Phosphoribosylamine-glycine ligase. (436 aa)
tmkCOG0125 Thymidylate kinase. (197 aa)
pyrFCOG0284 Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (276 aa)
C464_04718COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases. (474 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa)
C464_04938COG0262 Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (191 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (342 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (443 aa)
C464_05715COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase. (355 aa)
C464_06370COG0518 GMP synthase - Glutamine amidotransferase domain. (235 aa)
C464_06728Ham1 family protein; COG0127 Xanthosine triphosphate pyrophosphatase. (221 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (207 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (373 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (202 aa)
C464_07615COG0518 GMP synthase - Glutamine amidotransferase domain. (237 aa)
C464_07710COG0295 Cytidine deaminase. (134 aa)
C464_07715COG2820 Uridine phosphorylase. (272 aa)
C464_07950COG0015 Adenylosuccinate lyase. (488 aa)
C464_07955COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. (534 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (495 aa)
purMCOG0150 Phosphoribosylaminoimidazole (AIR) synthetase. (348 aa)
C464_09677COG0223 Methionyl-tRNA formyltransferase. (244 aa)
C464_10009Adenine phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown. (189 aa)
C464_10104COG0516 IMP dehydrogenase/GMP reductase. (369 aa)
C464_10518Nucleotide kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (198 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (451 aa)
C464_10853COG0788 Formyltetrahydrofolate hydrolase. (326 aa)
purSPhosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (83 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (225 aa)
surESurvival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (264 aa)
purDCOG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (427 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa)
pyrBCOG0540 Aspartate carbamoyltransferase, catalytic chain. (315 aa)
C464_11915COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases. (108 aa)
C464_11930COG0212 5-formyltetrahydrofolate cyclo-ligase. (249 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (499 aa)
C464_12470COG0209 Ribonucleotide reductase, alpha subunit. (562 aa)
C464_12475COG0208 Ribonucleotide reductase, beta subunit. (342 aa)
C464_13585COG2233 Xanthine/uracil permeases. (509 aa)
guaAAGMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. (184 aa)
C464_14190COG2352 Phosphoenolpyruvate carboxylase. (900 aa)
C464_14230COG2820 Uridine phosphorylase. (241 aa)
surE-2Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (289 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
C464_14480Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1051 aa)
guaABGMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (305 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (225 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (398 aa)
Your Current Organism:
Halorubrum coriense
NCBI taxonomy Id: 1227466
Other names: H. coriense DSM 10284, Halorubrum coriense DSM 10284
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