STRINGSTRING
C464_08695 C464_08695 C464_00484 C464_00484 C464_00954 C464_00954 pyrE pyrE C464_02545 C464_02545 carB carB udk udk tdk tdk tmk tmk pyrF pyrF C464_03861 C464_03861 cmk cmk ndk ndk C464_04718 C464_04718 thyA thyA pyrC pyrC C464_05465 C464_05465 C464_05975 C464_05975 C464_07100 C464_07100 C464_07710 C464_07710 C464_07715 C464_07715 C464_08320 C464_08320 C464_08590 C464_08590 C464_09492 C464_09492 tgtA tgtA C464_09597 C464_09597 cmk-2 cmk-2 C464_10898 C464_10898 C464_11373 C464_11373 surE surE pyrI pyrI pyrB pyrB C464_12367 C464_12367 C464_12470 C464_12470 C464_12475 C464_12475 C464_12870 C464_12870 dcd dcd C464_14230 C464_14230 surE-2 surE-2 C464_14335 C464_14335 pyrH pyrH C464_14480 C464_14480 pyrG pyrG upp upp C464_17062 C464_17062
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C464_08695Hypothetical protein; COG1611 Predicted Rossmann fold nucleotide-binding protein. (182 aa)
C464_00484Deoxyuridine 5'-triphosphate nucleotidohydrolase; COG0717 Deoxycytidine deaminase. (157 aa)
C464_00954Hypothetical protein. (49 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (184 aa)
C464_02545Metal dependent phosphohydrolase; COG1896 Predicted hydrolases of HD superfamily. (235 aa)
carBCOG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1073 aa)
udkCOG0572 Uridine kinase. (232 aa)
tdkCOG1435 Thymidine kinase. (213 aa)
tmkCOG0125 Thymidylate kinase. (197 aa)
pyrFCOG0284 Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (276 aa)
C464_03861Hypothetical protein. (46 aa)
cmkCOG1102 Cytidylate kinase. (192 aa)
ndkMulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (159 aa)
C464_04718COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases. (474 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (342 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (443 aa)
C464_05465COG0343 Queuine/archaeosine tRNA-ribosyltransferase. (327 aa)
C464_05975Transcription termination factor Tfs; COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (109 aa)
C464_07100Hypothetical protein; COG1645 Uncharacterized Zn-finger containing protein. (234 aa)
C464_07710COG0295 Cytidine deaminase. (134 aa)
C464_07715COG2820 Uridine phosphorylase. (272 aa)
C464_08320NAD operon protein. (307 aa)
C464_08590Orotate phosphoribosyltransferase-like protein; COG0856 Orotate phosphoribosyltransferase homologs; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (210 aa)
C464_09492CMP/dCMP deaminase zinc-binding protein; COG0590 Cytosine/adenosine deaminases. (172 aa)
tgtA7-cyano-7-deazaguanine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (492 aa)
C464_09597NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (148 aa)
cmk-2COG1102 Cytidylate kinase. (204 aa)
C464_10898Mut/nudix family protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (175 aa)
C464_11373Transcription factor TFIIS; COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS. (97 aa)
surESurvival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (264 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa)
pyrBCOG0540 Aspartate carbamoyltransferase, catalytic chain. (315 aa)
C464_12367Amidase, hydantoinase/carbamoylase family protein; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (436 aa)
C464_12470COG0209 Ribonucleotide reductase, alpha subunit. (562 aa)
C464_12475COG0208 Ribonucleotide reductase, beta subunit. (342 aa)
C464_12870Mut/nudix family protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (137 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (208 aa)
C464_14230COG2820 Uridine phosphorylase. (241 aa)
surE-2Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (289 aa)
C464_14335COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation. (59 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
C464_14480Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1051 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (539 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (225 aa)
C464_17062COG0717 Deoxycytidine deaminase. (142 aa)
Your Current Organism:
Halorubrum coriense
NCBI taxonomy Id: 1227466
Other names: H. coriense DSM 10284, Halorubrum coriense DSM 10284
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