STRINGSTRING
C494_00377 C494_00377 priS priS topA topA mre11 mre11 rad50 rad50 C494_01182 C494_01182 taw1 taw1 C494_02850 C494_02850 mutL mutL mutS-2 mutS-2 cca cca C494_04610 C494_04610 C494_04615 C494_04615 C494_04620 C494_04620 C494_04785 C494_04785 cdc6 cdc6 C494_05330 C494_05330 polC polC C494_05743 C494_05743 C494_05843 C494_05843 polB polB C494_05988 C494_05988 C494_06260 C494_06260 C494_06605 C494_06605 rfcL rfcL C494_07310 C494_07310 C494_07515 C494_07515 C494_07520 C494_07520 C494_07640 C494_07640 lig lig C494_08437 C494_08437 C494_08447 C494_08447 C494_08712 C494_08712 C494_08832 C494_08832 C494_08967 C494_08967 priL priL pcn pcn taw2 taw2 radA radA C494_11515 C494_11515 tgtA tgtA rnhB rnhB C494_12040 C494_12040 C494_12686 C494_12686 C494_13361 C494_13361 C494_14156 C494_14156 C494_14748 C494_14748 C494_15158 C494_15158 C494_16138 C494_16138 C494_16658 C494_16658 C494_16713 C494_16713 C494_16823 C494_16823 C494_16993 C494_16993 dbh dbh radB radB C494_19247 C494_19247 fen fen C494_20013 C494_20013 C494_20413 C494_20413
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C494_00377Cell division control protein 6-like protein; Involved in regulation of DNA replication. (398 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (391 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (828 aa)
mre11Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. (425 aa)
rad50Chromosome segregation protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily. (892 aa)
C494_01182COG0417 DNA polymerase elongation subunit (family B). (1346 aa)
taw1tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (344 aa)
C494_02850COG0012 Predicted GTPase, probable translation factor. (399 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (730 aa)
mutS-2DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (877 aa)
ccatRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (467 aa)
C494_04610COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. (342 aa)
C494_04615Transcription factor CBF/NF-Y/histone domain-containing protein; COG2036 Histones H3 and H4. (143 aa)
C494_04620Replication factor A; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (483 aa)
C494_04785Cell division control protein/MCM family protein; COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family. (1172 aa)
cdc6Cell division control protein 6; Involved in regulation of DNA replication. (376 aa)
C494_05330Thermosome; COG0459 Chaperonin GroEL (HSP60 family); Belongs to the TCP-1 chaperonin family. (557 aa)
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1719 aa)
C494_05743Replication factor C small subunit 2; COG0470 ATPase involved in DNA replication. (334 aa)
C494_05843Replication factor C small subunit; COG0470 ATPase involved in DNA replication. (1029 aa)
polBDNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (522 aa)
C494_05988Cell division control protein 6-like protein; Involved in regulation of DNA replication. (534 aa)
C494_06260Hef nuclease; COG1111 ERCC4-like helicases. (810 aa)
C494_06605OB-fold tRNA/helicase-type nucleic acid binding-protein; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (282 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (495 aa)
C494_07310Hypothetical protein; COG1938 Archaeal enzymes of ATP-grasp superfamily. (246 aa)
C494_07515COG0417 DNA polymerase elongation subunit (family B). (951 aa)
C494_07520Family B DNA-directed DNA polymerase; COG0593 ATPase involved in DNA replication initiation. (192 aa)
C494_07640Hypothetical protein; COG1948 ERCC4-type nuclease. (145 aa)
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (579 aa)
C494_08437ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (419 aa)
C494_08447Cell division control protein 6; Involved in regulation of DNA replication. (400 aa)
C494_08712Helicase; COG0553 Superfamily II DNA/RNA helicases, SNF2 family. (585 aa)
C494_08832Hypothetical protein. (82 aa)
C494_08967OB-fold tRNA/helicase-type nucleic acid binding-protein; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (238 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (360 aa)
pcnDNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
taw2Hypothetical protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (383 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (343 aa)
C494_11515Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (410 aa)
tgtA7-cyano-7-deazaguanine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (493 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (227 aa)
C494_12040PUA domain containing protein; COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit. (198 aa)
C494_12686tRNA 2'-O-methylase; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (182 aa)
C494_13361Hypothetical protein; COG1938 Archaeal enzymes of ATP-grasp superfamily. (250 aa)
C494_14156Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (444 aa)
C494_14748Phosphate regulatory protein-like protein; COG0704 Phosphate uptake regulator. (353 aa)
C494_15158Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (286 aa)
C494_16138Cell division control protein 6; Involved in regulation of DNA replication. (400 aa)
C494_16658COG1491 Predicted RNA-binding protein. (196 aa)
C494_16713Hypothetical protein; Involved in DNA damage repair. (433 aa)
C494_16823COG1796 DNA polymerase IV (family X). (583 aa)
C494_16993Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (410 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (419 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (235 aa)
C494_19247Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (427 aa)
fenFlap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (325 aa)
C494_20013Cell division control protein 6-like protein; Involved in regulation of DNA replication. (353 aa)
C494_20413Hypothetical protein. (693 aa)
Your Current Organism:
Natronorubrum bangense
NCBI taxonomy Id: 1227500
Other names: N. bangense JCM 10635, Natronorubrum bangense JCM 10635
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