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rps17p rps17p PhaC PhaC rpl24e rpl24e rps28e rps28e C494_00377 C494_00377 rps2P rps2P rps9p rps9p rps4p rps4p priS priS C494_00677 C494_00677 C494_00707 C494_00707 rps3ae rps3ae rpl37ae rpl37ae mre11 mre11 rad50 rad50 rplP0 rplP0 rpl12p rpl12p C494_01587 C494_01587 C494_01871 C494_01871 C494_02246 C494_02246 rpl15e rpl15e C494_02990 C494_02990 rps24e rps24e rps10p rps10p C494_03530 C494_03530 rpl40e rpl40e C494_03800 C494_03800 C494_04216 C494_04216 C494_04490 C494_04490 C494_04615 C494_04615 cdc6 cdc6 C494_05743 C494_05743 C494_05843 C494_05843 C494_05988 C494_05988 C494_06415 C494_06415 C494_06495 C494_06495 C494_06820 C494_06820 C494_06855 C494_06855 DndD DndD CyaB CyaB rbcL rbcL rfcL rfcL dnaJ dnaJ C494_07595 C494_07595 C494_08045 C494_08045 C494_08060 C494_08060 rps17E rps17E C494_08437 C494_08437 C494_08447 C494_08447 C494_08547 C494_08547 C494_08577 C494_08577 C494_08617 C494_08617 C494_08677 C494_08677 C494_09149 C494_09149 C494_09239 C494_09239 priL priL rpl31e rpl31e rps6e rps6e rps19e rps19e C494_10620 C494_10620 C494_10845 C494_10845 pdxS pdxS cetZ cetZ C494_11515 C494_11515 nop10 nop10 rpl44e rpl44e C494_13111 C494_13111 nth nth C494_13271 C494_13271 C494_14156 C494_14156 C494_14698 C494_14698 C494_15158 C494_15158 C494_15218 C494_15218 C494_15233 C494_15233 C494_15328 C494_15328 C494_15458 C494_15458 C494_15608 C494_15608 C494_15913 C494_15913 C494_16138 C494_16138 C494_16348 C494_16348 C494_16498 C494_16498 C494_16553 C494_16553 rpl21e rpl21e C494_16863 C494_16863 C494_16993 C494_16993 C494_17053 C494_17053 C494_17148 C494_17148 C494_17173 C494_17173 C494_17603 C494_17603 flpA flpA C494_17663 C494_17663 dbh dbh C494_17778 C494_17778 C494_18167 C494_18167 rps19p rps19p rps3p rps3p rpl29 rpl29 rps4e rps4e rpl6p rpl6p rpl32e rpl32e rpl19e rpl19e rpl18p rpl18p rps5p rps5p truB truB top6A top6A C494_18598 C494_18598 C494_18603 C494_18603 C494_18608 C494_18608 C494_18613 C494_18613 C494_18633 C494_18633 gvpA gvpA GvpN GvpN rps10 rps10 C494_18843 C494_18843 cetZ-2 cetZ-2 C494_18912 C494_18912 C494_18927 C494_18927 smc smc C494_19247 C494_19247 C494_19447 C494_19447 C494_20013 C494_20013 C494_20223 C494_20223 C494_20433 C494_20433
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rps17p30S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (144 aa)
PhaCpoly(R)-hydroxyalkanoic acid synthase subunit PhaC; COG3243 Poly(3-hydroxyalkanoate) synthetase. (490 aa)
rpl24e50S ribosomal protein L24E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL24 family. (109 aa)
rps28eCOG2053 Ribosomal protein S28E/S33; Belongs to the eukaryotic ribosomal protein eS28 family. (74 aa)
C494_00377Cell division control protein 6-like protein; Involved in regulation of DNA replication. (398 aa)
rps2PCOG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (267 aa)
rps9pCOG0103 Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rps4p30S ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (173 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (391 aa)
C494_00677COG1695 Predicted transcriptional regulators. (119 aa)
C494_00707HhH-GPD family protein; COG0177 Predicted EndoIII-related endonuclease. (270 aa)
rps3aeCOG1890 Ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (213 aa)
rpl37ae50S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. (86 aa)
mre11Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. (425 aa)
rad50Chromosome segregation protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily. (892 aa)
rplP0Acidic ribosomal protein P0; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (346 aa)
rpl12p50S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
C494_01587Chromosome segregation ATPase-like protein. (935 aa)
C494_01871Silent information regulator protein Sir2; COG0846 NAD-dependent protein deacetylases, SIR2 family. (256 aa)
C494_02246COG1378 Predicted transcriptional regulators. (252 aa)
rpl15eCOG1632 Ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (196 aa)
C494_02990Hypothetical protein. (230 aa)
rps24eCOG2004 Ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (105 aa)
rps10p30S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
C494_03530Hypothetical protein. (347 aa)
rpl40eCOG1552 Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa)
C494_03800Cell division control protein 6-like protein; Involved in regulation of DNA replication. (399 aa)
C494_04216COG1378 Predicted transcriptional regulators. (267 aa)
C494_04490Hypothetical protein; COG0469 Pyruvate kinase. (279 aa)
C494_04615Transcription factor CBF/NF-Y/histone domain-containing protein; COG2036 Histones H3 and H4. (143 aa)
cdc6Cell division control protein 6; Involved in regulation of DNA replication. (376 aa)
C494_05743Replication factor C small subunit 2; COG0470 ATPase involved in DNA replication. (334 aa)
C494_05843Replication factor C small subunit; COG0470 ATPase involved in DNA replication. (1029 aa)
C494_05988Cell division control protein 6-like protein; Involved in regulation of DNA replication. (534 aa)
C494_06415Hypothetical protein; COG1215 Glycosyltransferases, probably involved in cell wall biogenesis. (407 aa)
C494_06495COG0206 Cell division GTPase. (381 aa)
C494_06820Phosphoesterase RecJ domain-containing protein; COG1226 Kef-type K+ transport systems, predicted NAD-binding component. (482 aa)
C494_06855Hypothetical protein; COG0419 ATPase involved in DNA repair. (650 aa)
DndDDNA sulfur modification protein DndD; COG0419 ATPase involved in DNA repair. (686 aa)
CyaBAdenylyl cyclase CyaB; COG1437 Adenylate cyclase, class 2 (thermophilic). (181 aa)
rbcLRibulose bisophosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (416 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (495 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (387 aa)
C494_07595Hypothetical protein; COG2219 Eukaryotic-type DNA primase, large subunit. (347 aa)
C494_08045Phosphoesterase RecJ domain-containing protein; COG0618 Exopolyphosphatase-related proteins. (334 aa)
C494_08060Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. (229 aa)
rps17ECOG1383 Ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (63 aa)
C494_08437ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (419 aa)
C494_08447Cell division control protein 6; Involved in regulation of DNA replication. (400 aa)
C494_08547Mrr restriction system protein-like protein; COG1715 Restriction endonuclease. (454 aa)
C494_08577ATPase; COG1672 Predicted ATPase (AAA+ superfamily). (471 aa)
C494_08617Orc1-type DNA replication protein; Involved in regulation of DNA replication. (463 aa)
C494_08677SMC domain-containing protein; COG0419 ATPase involved in DNA repair. (987 aa)
C494_09149ATPase associated with various cellular activities AAA 3; COG0714 MoxR-like ATPases. (324 aa)
C494_09239Small GTP-binding protein; COG1084 Predicted GTPase. (331 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (360 aa)
rpl31eCOG2097 Ribosomal protein L31E; Belongs to the ribosomal protein L31e family. (92 aa)
rps6eCOG2125 Ribosomal protein S6E (S10); Belongs to the eukaryotic ribosomal protein eS6 family. (133 aa)
rps19e30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (151 aa)
C494_10620COG1715 Restriction endonuclease. (452 aa)
C494_10845ATPase; COG0714 MoxR-like ATPases. (317 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (302 aa)
cetZTubulin/FtsZ GTPase; Involved in cell shape control; Belongs to the CetZ family. (392 aa)
C494_11515Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (410 aa)
nop10H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (59 aa)
rpl44e50S ribosomal protein L44e; Binds to the 23S rRNA. (93 aa)
C494_13111Phosphoesterase RecJ domain-containing protein; COG1226 Kef-type K+ transport systems, predicted NAD-binding component. (499 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
C494_13271Glycosyl transferase family protein. (163 aa)
C494_14156Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (444 aa)
C494_14698Transcriptional regulator, TrmB; COG1378 Predicted transcriptional regulators. (268 aa)
C494_15158Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (286 aa)
C494_15218Hypothetical protein; COG1672 Predicted ATPase (AAA+ superfamily). (317 aa)
C494_15233ATPase; COG1672 Predicted ATPase (AAA+ superfamily). (87 aa)
C494_15328Hypothetical protein. (419 aa)
C494_15458COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (234 aa)
C494_15608Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (401 aa)
C494_15913Kinetochore-Ndc80 complex, subunit Spc25; COG0419 ATPase involved in DNA repair. (652 aa)
C494_16138Cell division control protein 6; Involved in regulation of DNA replication. (400 aa)
C494_16348Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (303 aa)
C494_16498DNA methylase N-4/N-6 domain-containing protein; COG0863 DNA modification methylase. (350 aa)
C494_16553Metal dependent phosphohydrolase; COG1078 HD superfamily phosphohydrolases. (410 aa)
rpl21eCOG2139 Ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (102 aa)
C494_16863Hypothetical protein. (66 aa)
C494_16993Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (410 aa)
C494_17053H/ACA RNA-protein complex component Gar1; COG3277 RNA-binding protein involved in rRNA processing. (84 aa)
C494_17148Hypothetical protein. (554 aa)
C494_17173Hypothetical protein; COG1077 Actin-like ATPase involved in cell morphogenesis. (334 aa)
C494_17603Pre-mRNA processing ribonucleoprotein, binding domain-containing protein; COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog. (290 aa)
flpAFibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (214 aa)
C494_17663Heat shock protein DnaJ domain protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. (447 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (419 aa)
C494_17778DNA methylase N-4/N-6 domain-containing protein; COG0863 DNA modification methylase. (354 aa)
C494_18167Hypothetical protein. (300 aa)
rps19p30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (140 aa)
rps3p30S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (308 aa)
rpl29COG0255 Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (70 aa)
rps4eCOG1471 Ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (233 aa)
rpl6p50S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpl32e50S ribosomal protein L32e; COG0468 RecA/RadA recombinase; Belongs to the eukaryotic ribosomal protein eL32 family. (241 aa)
rpl19e50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (149 aa)
rpl18p50S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (182 aa)
rps5p30S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (216 aa)
truBH/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (306 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (363 aa)
C494_18598Gas vesicle protein GvpA; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. (100 aa)
C494_18603Gas vesicle synthesis protein GvpLGvpF. (301 aa)
C494_18608Gas vesicle K. (114 aa)
C494_18613Gas vesicle protein GVPa; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. (177 aa)
C494_18633Gas vesicle synthesis protein GvpLGvpF. (207 aa)
gvpAGas vesicle synthesis protein GvpA; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure. (101 aa)
GvpNGas vesicle protein GvpN; COG0714 MoxR-like ATPases. (345 aa)
rps1030S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (111 aa)
C494_18843Saccharopine dehydrogenase. (372 aa)
cetZ-2Tubulin/FtsZ GTPase; Involved in cell shape control; Belongs to the CetZ family. (360 aa)
C494_18912Phosphoesterase RecJ domain-containing protein; COG0618 Exopolyphosphatase-related proteins. (395 aa)
C494_18927Hypothetical protein. (102 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1194 aa)
C494_19247Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (427 aa)
C494_19447ATPase; COG0714 MoxR-like ATPases. (323 aa)
C494_20013Cell division control protein 6-like protein; Involved in regulation of DNA replication. (353 aa)
C494_20223AAA ATPase; COG0714 MoxR-like ATPases. (327 aa)
C494_20433ATPase AAA; COG0714 MoxR-like ATPases. (337 aa)
Your Current Organism:
Natronorubrum bangense
NCBI taxonomy Id: 1227500
Other names: N. bangense JCM 10635, Natronorubrum bangense JCM 10635
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