(5 nodes) Synthesis and degradation of ketone bodies network (Pestalotiopsis fici)

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Your Input:
	PFICI_14097	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (460 aa)
	PFICI_13661	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
	PFICI_12821	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (527 aa)
	PFICI_11099	Pyruvate carboxyltransferase domain-containing protein. (601 aa)
	PFICI_09931	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)

Your Current Organism:

Pestalotiopsis fici

NCBI taxonomy Id: 1229662
Other names: P. fici W106-1, Pestalotiopsis fici W106-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PFICI_09931	PFICI_11099	W3WVM7	W3WTQ9	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate carboxyltransferase domain-containing protein.	0.928
PFICI_09931	PFICI_12821	W3WVM7	W3WRV8	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.902
PFICI_09931	PFICI_13661	W3WVM7	W3WPV1	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.914
PFICI_09931	PFICI_14097	W3WVM7	W3WN57	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.980
PFICI_11099	PFICI_09931	W3WTQ9	W3WVM7	Pyruvate carboxyltransferase domain-containing protein.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.928
PFICI_11099	PFICI_12821	W3WTQ9	W3WRV8	Pyruvate carboxyltransferase domain-containing protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.940
PFICI_11099	PFICI_13661	W3WTQ9	W3WPV1	Pyruvate carboxyltransferase domain-containing protein.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.931
PFICI_11099	PFICI_14097	W3WTQ9	W3WN57	Pyruvate carboxyltransferase domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.950
PFICI_12821	PFICI_09931	W3WRV8	W3WVM7	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.902
PFICI_12821	PFICI_11099	W3WRV8	W3WTQ9	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	Pyruvate carboxyltransferase domain-containing protein.	0.940
PFICI_12821	PFICI_13661	W3WRV8	W3WPV1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.952
PFICI_12821	PFICI_14097	W3WRV8	W3WN57	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.925
PFICI_13661	PFICI_09931	W3WPV1	W3WVM7	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.914
PFICI_13661	PFICI_11099	W3WPV1	W3WTQ9	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate carboxyltransferase domain-containing protein.	0.931
PFICI_13661	PFICI_12821	W3WPV1	W3WRV8	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.952
PFICI_13661	PFICI_14097	W3WPV1	W3WN57	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.988
PFICI_14097	PFICI_09931	W3WN57	W3WVM7	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.980
PFICI_14097	PFICI_11099	W3WN57	W3WTQ9	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Pyruvate carboxyltransferase domain-containing protein.	0.950
PFICI_14097	PFICI_12821	W3WN57	W3WRV8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.925
PFICI_14097	PFICI_13661	W3WN57	W3WPV1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.988