(21 nodes) Terpenoid backbone biosynthesis network (Pestalotiopsis fici)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PFICI_14449	Hexaprenyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (361 aa)
	PFICI_14651	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (226 aa)
	PFICI_14185	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (461 aa)
	PFICI_13524	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1155 aa)
	PFICI_14097	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (460 aa)
	PFICI_12628	Uncharacterized protein. (317 aa)
	PFICI_13661	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
	PFICI_12842	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (442 aa)
	PFICI_12069	Uncharacterized protein. (516 aa)
	PFICI_12068	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (516 aa)
	PFICI_08578	Abhydrolase_3 domain-containing protein. (288 aa)
	PFICI_08852	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (388 aa)
	PFICI_07492	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (363 aa)
	PFICI_09320	Alkyl transferase; Belongs to the UPP synthase family. (354 aa)
	PFICI_08307	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (358 aa)
	PFICI_07635	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	PFICI_06391	Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (399 aa)
	PFICI_04235	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (431 aa)
	PFICI_04845	Isopentenyl-diphosphate Delta-isomerase. (254 aa)
	PFICI_03485	Prenylcys_lyase domain-containing protein. (563 aa)
	PFICI_01895	Uncharacterized protein. (343 aa)

Your Current Organism:

Pestalotiopsis fici

NCBI taxonomy Id: 1229662
Other names: P. fici W106-1, Pestalotiopsis fici W106-1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PFICI_01895	PFICI_04845	W3XRC5	W3XAB6	Uncharacterized protein.	Isopentenyl-diphosphate Delta-isomerase.	0.659
PFICI_01895	PFICI_06391	W3XRC5	W3X5T7	Uncharacterized protein.	Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.937
PFICI_01895	PFICI_08307	W3XRC5	W3X3S4	Uncharacterized protein.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.937
PFICI_01895	PFICI_09320	W3XRC5	W3X260	Uncharacterized protein.	Alkyl transferase; Belongs to the UPP synthase family.	0.999
PFICI_01895	PFICI_12069	W3XRC5	W3WU61	Uncharacterized protein.	Uncharacterized protein.	0.925
PFICI_01895	PFICI_14185	W3XRC5	W3WKQ6	Uncharacterized protein.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.924
PFICI_01895	PFICI_14449	W3XRC5	W3WHX9	Uncharacterized protein.	Hexaprenyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.937
PFICI_03485	PFICI_07635	W3XHF0	W3X4K3	Prenylcys_lyase domain-containing protein.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.412
PFICI_03485	PFICI_08852	W3XHF0	W3WYZ0	Prenylcys_lyase domain-containing protein.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.611
PFICI_03485	PFICI_14185	W3XHF0	W3WKQ6	Prenylcys_lyase domain-containing protein.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.655
PFICI_04235	PFICI_04845	W3X8L0	W3XAB6	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Isopentenyl-diphosphate Delta-isomerase.	0.484
PFICI_04235	PFICI_08307	W3X8L0	W3X3S4	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.466
PFICI_04235	PFICI_08852	W3X8L0	W3WYZ0	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.670
PFICI_04235	PFICI_12068	W3X8L0	W3WV02	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.719
PFICI_04235	PFICI_12842	W3X8L0	W3WPW0	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.490
PFICI_04235	PFICI_13524	W3X8L0	W3WM89	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.562
PFICI_04235	PFICI_13661	W3X8L0	W3WPV1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.904
PFICI_04235	PFICI_14097	W3X8L0	W3WN57	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.984
PFICI_04235	PFICI_14651	W3X8L0	W3WIF2	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.984
PFICI_04845	PFICI_01895	W3XAB6	W3XRC5	Isopentenyl-diphosphate Delta-isomerase.	Uncharacterized protein.	0.659