STRINGSTRING
FOC1_g10016052 FOC1_g10016052 NCS6 NCS6 FOC1_g10014881 FOC1_g10014881 FOC1_g10016261 FOC1_g10016261 uba4 uba4 FOC1_g10008100 FOC1_g10008100 FOC1_g10014247 FOC1_g10014247 FOC1_g10010264 FOC1_g10010264 FOC1_g10000807 FOC1_g10000807 FOC1_g10005847 FOC1_g10005847 FOC1_g10013809 FOC1_g10013809 FOC1_g10013139 FOC1_g10013139 FOC1_g10008709 FOC1_g10008709 FOC1_g10010993 FOC1_g10010993 FOC1_g10014067 FOC1_g10014067 FOC1_g10014486 FOC1_g10014486 FOC1_g10007275 FOC1_g10007275 FOC1_g10000035 FOC1_g10000035 FOC1_g10009561 FOC1_g10009561 NCS2 NCS2 MEF1 MEF1 FOC1_g10011129 FOC1_g10011129 FOC1_g10000034 FOC1_g10000034 FOC1_g10010506 FOC1_g10010506 FOC1_g10010654 FOC1_g10010654
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
FOC1_g10016052Methyltransf_11 domain-containing protein. (300 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (388 aa)
FOC1_g10014881Uncharacterized protein. (267 aa)
FOC1_g100162612-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (453 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (448 aa)
FOC1_g100081002-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2; Belongs to the DPH1/DPH2 family. DPH2 subfamily. (536 aa)
FOC1_g10014247Elongator complex protein 5. (343 aa)
FOC1_g10010264Uncharacterized protein. (462 aa)
FOC1_g10000807Uncharacterized protein. (58 aa)
FOC1_g10005847Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (572 aa)
FOC1_g10013809Meiotically up-regulated protein 71 protein. (846 aa)
FOC1_g10013139Thiosulfate sulfurtransferase TUM1. (338 aa)
FOC1_g10008709Protein kti12. (374 aa)
FOC1_g10010993Allergen Asp f 7. (271 aa)
FOC1_g10014067WD repeat-containing protein 85 like protein. (408 aa)
FOC1_g10014486Diphthamide biosynthesis protein 3. (86 aa)
FOC1_g10007275Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1297 aa)
FOC1_g10000035Allergen Asp f 7. (235 aa)
FOC1_g10009561Uncharacterized protein. (354 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (389 aa)
MEF1Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (789 aa)
FOC1_g10011129Diphthine synthase. (287 aa)
FOC1_g10000034Allergen Asp f 7. (235 aa)
FOC1_g10010506RCC1 repeat-containing protein C10F6.04. (362 aa)
FOC1_g10010654Elongator complex protein 4. (378 aa)
Your Current Organism:
Fusarium oxysporum f. sp. cubense race 1
NCBI taxonomy Id: 1229664
Other names: F. oxysporum f. sp. cubense race 1
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