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| | GRFL_3627 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa) |
| | GRFL_3618 | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa) |
| | GRFL_3606 | Aldo-keto reductase family 1 member B10. (315 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (126 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (456 aa) |
| | GRFL_3529 | L-allo-threonine aldolase. (343 aa) |
| | GRFL_3525 | Cystathionine beta-synthase. (346 aa) |
| | GRFL_3524 | 2-amino-3-ketobutyrate coenzyme A ligase. (421 aa) |
| | GRFL_3510 | Alanine dehydrogenase. (387 aa) |
| | lpxC | N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (460 aa) |
| | GRFL_3495 | Hypothetical protein. (674 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa) |
| | hisB | Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (379 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (193 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (242 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (206 aa) |
| | GRFL_3471 | Succinylglutamate desuccinylase. (303 aa) |
| | GRFL_3441 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa) |
| | GRFL_3412 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (499 aa) |
| | GRFL_3339 | Histidine ammonia-lyase. (515 aa) |
| | GRFL_3334 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (365 aa) |
| | GRFL_3333 | 3-oxoacyl-[acyl-carrier protein] reductase. (199 aa) |
| | GRFL_3332 | Acyl carrier protein. (85 aa) |
| | GRFL_3331 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (393 aa) |
| | GRFL_3330 | 3-oxoacyl-[acyl-carrier protein] reductase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (351 aa) |
| | GRFL_3326 | (3R)-hydroxymyristoyl-[ACP] dehydratase. (122 aa) |
| | pfkA-2 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa) |
| | GRFL_3302 | Lactate dehydrogenase. (971 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | GRFL_3286 | Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit. (668 aa) |
| | GRFL_3265 | Bifunctional protein: zinc-containing alcohol dehydrogenase; Quinone oxidoreductase (NADPH:quinone reductase); Similar to arginate lyase; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (334 aa) |
| | GRFL_3243 | Aspartokinase; Belongs to the aspartokinase family. (444 aa) |
| | GRFL_3224 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (295 aa) |
| | GRFL_3223 | Serine acetyltransferase. (263 aa) |
| | GRFL_3205 | Cytosolic long-chain acyl-CoA thioester hydrolase family protein. (128 aa) |
| | GRFL_3202 | Succinate-semialdehyde dehydrogenase [NADP+]. (452 aa) |
| | GRFL_3196 | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | GRFL_3190 | Histidine ammonia-lyase. (510 aa) |
| | gcvT | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. (360 aa) |
| | GRFL_3183 | Carbapenem antibiotics biosynthesis protein carD. (399 aa) |
| | GRFL_3182 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (376 aa) |
| | GRFL_3177 | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (857 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (354 aa) |
| | GRFL_3135 | Metal-dependent hydrolases of the beta-lactamase superfamily I; PhnP protein. (195 aa) |
| | GRFL_3123 | Aminodeoxychorismate lyase. (281 aa) |
| | GRFL_3043 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (304 aa) |
| | GRFL_3041 | Fructose-bisphosphate aldolase class I. (353 aa) |
| | hisS | Histidyl-tRNA synthetase. (456 aa) |
| | GRFL_2959 | Acyl CoA thioester hydrolase family protein. (182 aa) |
| | GRFL_2931 | Long-chain-fatty-acid--CoA ligase. (592 aa) |
| | GRFL_2927 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa) |
| | GRFL_2925 | Gluconolactonase. (285 aa) |
| | GRFL_2863 | Propionyl-CoA carboxylase beta chain. (513 aa) |
| | GRFL_2862 | Pyruvate carboxyl transferase subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (482 aa) |
| | GRFL_2861 | Biotin carboxyl carrier protein. (161 aa) |
| | GRFL_2852 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (467 aa) |
| | GRFL_2848 | Outer membrane protein. (343 aa) |
| | GRFL_2842 | Succinate-semialdehyde dehydrogenase [NADP+]. (460 aa) |
| | GRFL_2730 | Oxidoreductase of aldo/keto reductase family, subgroup 1. (297 aa) |
| | GRFL_2680 | Hypothetical protein. (173 aa) |
| | GRFL_2672 | Putative poly(beta-D-mannuronate) O-acetylase; Belongs to the membrane-bound acyltransferase family. (475 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (237 aa) |
| | GRFL_2640 | Secreted enzyme, contains two amidohydrolase related domains. (991 aa) |
| | GRFL_2639 | Hypothetical protein. (439 aa) |
| | GRFL_2630 | Acetylornithine aminotransferase (ACOAT); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (394 aa) |
| | GRFL_2626 | Shikimate 5-dehydrogenase I alpha. (241 aa) |
| | GRFL_2621 | Cystathionine gamma-lyase. (382 aa) |
| | hutI | Imidazolonepropionase. (419 aa) |
| | GRFL_2617 | Formiminoglutamase; Belongs to the arginase family. (327 aa) |
| | GRFL_2614 | Transcriptional regulator, MarR family. (152 aa) |
| | GRFL_2613 | Metal-dependent hydrolase. (271 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (425 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (509 aa) |
| | GRFL_2581 | Aromatic-L-amino-acid decarboxylase. (454 aa) |
| | GRFL_2575 | Fructose-bisphosphate aldolase class I. (59 aa) |
| | GRFL_2574 | Fructose-bisphosphate aldolase class I. (220 aa) |
| | GRFL_2563 | Fumarylacetoacetate hydrolase family protein. (204 aa) |
| | GRFL_2560 | Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (446 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa) |
| | GRFL_2548 | Fumarylacetoacetase. (429 aa) |
| | GRFL_2535 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | GRFL_2509 | Methylcrotonyl-CoA carboxylase carboxyl transferase subunit. (542 aa) |
| | GRFL_2503 | Metal-dependent hydrolase; Belongs to the UPF0173 family. (226 aa) |
| | GRFL_2491 | N-acyl-L-amino acid amidohydrolase. (423 aa) |
| | GRFL_2490 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (530 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (808 aa) |
| | fabH-2 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (336 aa) |
| | GRFL_2427 | Cystathionine beta-synthase. (326 aa) |
| | GRFL_2416 | Hypothetical protein. (624 aa) |
| | GRFL_2399 | Asparagine synthetase [glutamine-hydrolyzing]. (569 aa) |
| | GRFL_2327 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (355 aa) |
| | GRFL_2302 | Glutamine synthetase type II, eukaryotic. (341 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (504 aa) |
| | GRFL_2211 | Delta-1-pyrroline-5-carboxylate dehydrogenase. (542 aa) |
| | GRFL_2197 | Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa) |
| | accD | Acetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (288 aa) |
| | GRFL_2189 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa) |
| | GRFL_2171 | Altronate hydrolase. (537 aa) |
| | uxaC-2 | Uronate isomerase. (467 aa) |
| | aroA | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (405 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (150 aa) |
| | GRFL_2123 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I beta; Chorismate mutase I. (363 aa) |
| | GRFL_2122 | Prephenate and/or arogenate dehydrogenase (unknown specificity). (294 aa) |
| | GRFL_2121 | Biosynthetic Aromatic amino acid aminotransferase alpha. (381 aa) |
| | GRFL_2120 | Prephenate dehydratase. (275 aa) |
| | GRFL_2116 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (317 aa) |
| | GRFL_2115 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (888 aa) |
| | GRFL_2114 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (317 aa) |
| | metZ | O-acetylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (387 aa) |
| | GRFL_2103 | Aspartokinase; Homoserine dehydrogenase. (1126 aa) |
| | GRFL_2102 | O-succinylhomoserine sulfhydrylase. (430 aa) |
| | GRFL_2095 | Threonine dehydratase, catabolic. (313 aa) |
| | GRFL_2080 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa) |
| | GRFL_2066 | Cysteine desulfurase. (360 aa) |
| | GRFL_2065 | Hypothetical protein. (152 aa) |
| | GRFL_2064 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | GRFL_2061 | Malonyl CoA-acyl carrier protein transacylase. (294 aa) |
| | GRFL_2031 | Aromatic-amino-acid aminotransferase. (396 aa) |
| | GRFL_2026 | 1-aminocyclopropane-1-carboxylate deaminase. (310 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (662 aa) |
| | GRFL_2022 | Phenylalanine-4-hydroxylase - Long. (585 aa) |
| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (844 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | GRFL_1966 | NADP-dependent malic enzyme. (761 aa) |
| | GRFL_1930 | UDP-glucose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (463 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (431 aa) |
| | asnS | Asparaginyl-tRNA synthetase. (480 aa) |
| | GRFL_1857 | L-asparaginase. (342 aa) |
| | GRFL_1840 | N-formylkynurenine (Aryl-) formamidase. (250 aa) |
| | GRFL_1834 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (463 aa) |
| | GRFL_1789 | Biosynthetic arginine decarboxylase. (464 aa) |
| | GRFL_1788 | Agmatinase; Belongs to the arginase family. (292 aa) |
| | GRFL_1781 | Kynurenine formamidase, bacterial. (82 aa) |
| | GRFL_1780 | Kynurenine formamidase, bacterial. (151 aa) |
| | GRFL_1765 | Radical SAM. (352 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (362 aa) |
| | GRFL_1729 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (382 aa) |
| | GRFL_1727 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (207 aa) |
| | GRFL_1708 | Putative poly(beta-D-mannuronate) O-acetylase; Belongs to the membrane-bound acyltransferase family. (466 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (615 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (254 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | glyQS | Glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (514 aa) |
| | GRFL_1679 | Aspartokinase; Belongs to the aspartokinase family. (417 aa) |
| | GRFL_1677 | Hypothetical protein. (326 aa) |
| | GRFL_1669 | Seryl-tRNA synthetase. (423 aa) |
| | GRFL_1607 | 4-hydroxybutyrate coenzyme A transferase. (425 aa) |
| | GRFL_1553 | Cysteine desulfurase. (407 aa) |
| | GRFL_1552 | Cystathionine gamma-lyase. (380 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | GRFL_1514 | Fatty acid desaturase occurring in virulence cluster. (324 aa) |
| | GRFL_1508 | Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (517 aa) |
| | GRFL_1495 | Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa) |
| | GRFL_1492 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (417 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | GRFL_1487 | Amidophosphoribosyltransferase. (632 aa) |
| | GRFL_1478 | Methylglutaconyl-CoA hydratase. (254 aa) |
| | GRFL_1466 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (369 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa) |
| | GRFL_1455 | Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (444 aa) |
| | GRFL_1454 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (170 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (332 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (288 aa) |
| | GRFL_1394 | Beta-lactamase-like. (287 aa) |
| | GRFL_1382 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (108 aa) |
| | glnS | Glutaminyl-tRNA synthetase. (558 aa) |
| | gltX | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (498 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | GRFL_1331 | Acyl-CoA hydrolase. (170 aa) |
| | GRFL_1328 | Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (322 aa) |
| | GRFL_1292 | Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa) |
| | GRFL_1269 | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1134 aa) |
| | GRFL_1254 | Homogentisate 1,2-dioxygenase. (389 aa) |
| | GRFL_1253 | 4-hydroxyphenylpyruvate dioxygenase. (380 aa) |
| | GRFL_1251 | Tryptophan 2,3-dioxygenase. (324 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (543 aa) |
| | GRFL_1219 | Cysteine desulfurase, SufS subfamily; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (410 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (690 aa) |
| | aspS | Aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (583 aa) |
| | GRFL_1172 | Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa) |
| | GRFL_1132 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (310 aa) |
| | leuS | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (937 aa) |
| | GRFL_1130 | Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (366 aa) |
| | GRFL_1118 | Hypothetical protein. (294 aa) |
| | GRFL_1101 | Hypothetical protein; Belongs to the arginase family. (386 aa) |
| | lysS | Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (563 aa) |
| | GRFL_0958 | Glutamate synthase [NADPH] small chain. (486 aa) |
| | GRFL_0957 | Glutamate synthase [NADPH] large chain. (1507 aa) |
| | GRFL_0954 | Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (375 aa) |
| | GRFL_0953 | Glu/Leu/Phe/Val dehydrogenase family protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (408 aa) |
| | GRFL_0888 | Threonine dehydrogenase and related Zn-dependent dehydrogenases. (382 aa) |
| | GRFL_0858 | Hypothetical protein. (304 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (333 aa) |
| | GRFL_0838 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (557 aa) |
| | GRFL_0827 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII. (352 aa) |
| | gcvP | Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (949 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (370 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | argS | Arginyl-tRNA synthetase. (617 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa) |
| | GRFL_0718 | Asparagine synthetase [glutamine-hydrolyzing]. (536 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (308 aa) |
| | cysS | Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (494 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (492 aa) |
| | glsA | Glutaminase; Belongs to the glutaminase family. (304 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (433 aa) |
| | kmo | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (454 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (293 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (876 aa) |
| | GRFL_0665 | Hypothetical protein. (91 aa) |
| | GRFL_0662 | Hypothetical protein. (203 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (232 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa) |
| | GRFL_0604 | Aldo/keto reductase. (284 aa) |
| | GRFL_0582 | 1-pyrroline-4-hydroxy-2-carboxylate deaminase; Belongs to the DapA family. (305 aa) |
| | GRFL_0581 | Ketoglutarate semialdehyde dehydrogenase. (499 aa) |
| | GRFL_0551 | Lysine ketoglutarate reductase (LKR); Saccharopine dehydrogenase. (386 aa) |
| | GRFL_0524 | Amidohydrolase family enzyme. (458 aa) |
| | GRFL_0521 | Hypothetical protein. (543 aa) |
| | GRFL_0515 | Protein secretion chaperonin CsaA. (113 aa) |
| | GRFL_0509 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (367 aa) |
| | GRFL_0501 | Hydroxymethylglutaryl-CoA lyase. (274 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | accA | Acetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | thrS | Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (658 aa) |
| | GRFL_0453 | Monomeric isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (743 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (269 aa) |
| | GRFL_0434 | Putative acetyltransferase. (162 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | GRFL_0422 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa) |
| | GRFL_0419 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (273 aa) |
| | GRFL_0406 | 3-hydroxybutyryl-CoA dehydrogenase. (296 aa) |
| | GRFL_0393 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (311 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (386 aa) |
| | uxaC | Uronate isomerase. (467 aa) |
| | GRFL_0262 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (630 aa) |
| | GRFL_0261 | Glyceraldehyde-3-phosphate dehydrogenase, putative. (525 aa) |
| | GRFL_0228 | O-succinylhomoserine sulfhydrylase. (422 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (331 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa) |
| | GRFL_0175 | Acetolactate synthase large subunit. (576 aa) |
| | GRFL_0174 | Acetolactate synthase small subunit. (179 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | ilvA | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa) |
| | GRFL_0171 | Hypothetical protein. (209 aa) |
| | GRFL_0170 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (319 aa) |
| | proC-2 | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (263 aa) |
| | GRFL_0167 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (377 aa) |
| | GRFL_0166 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (315 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (258 aa) |
| | GRFL_0164 | Acetylornithine deacetylase. (356 aa) |
| | argH | Argininosuccinate lyase. (423 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (372 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (204 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (460 aa) |
| | GRFL_0159 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (390 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (272 aa) |
| | GRFL_0146 | Ethanolamine ammonia-lyase light chain; Belongs to the EutC family. (249 aa) |
| | GRFL_0145 | Ethanolamine ammonia-lyase heavy chain. (454 aa) |
| | GRFL_0121 | Acyl carrier protein phosphodiesterase. (195 aa) |
| | GRFL_0105 | UDP-glucose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (446 aa) |
| | GRFL_0092 | 4-hydroxy-2-oxovalerate aldolase. (515 aa) |
| | GRFL_0084 | Hypothetical protein. (313 aa) |
| | GRFL_0062 | Aspartokinase; Homoserine dehydrogenase. (815 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa) |
| | GRFL_0060 | Threonine synthase. (432 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (383 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (257 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (663 aa) |
