STRINGSTRING
ilvA ilvA AKG03821.1 AKG03821.1 thrB thrB AKG03875.1 AKG03875.1 AKG03876.1 AKG03876.1 ilvD ilvD AKG04612.1 AKG04612.1 AKG04613.1 AKG04613.1 eutB eutB leuD leuD leuC leuC leuB leuB leuA leuA ilvC ilvC AKG04751.1 AKG04751.1 AKG04752.1 AKG04752.1 ilvE ilvE AKG05742.1 AKG05742.1 AKG04926.1 AKG04926.1 AKG05059.1 AKG05059.1 AKG05161.1 AKG05161.1 AKG05255.1 AKG05255.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
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ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa)
AKG03821.1Acetolactate synthase; Belongs to the TPP enzyme family. (542 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa)
AKG03875.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
AKG03876.1Homoserine dehydrogenase. (432 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (564 aa)
AKG04612.1L-serine dehydratase, iron-sulfur-dependent subunit alpha. (289 aa)
AKG04613.1L-serine dehydratase, iron-sulfur-dependent subunit beta. (220 aa)
eutBHydroxyectoine utilization dehydratase EutB; Catalyzes the formation of 2-oxobutanoate from L-threonine; involved in ectoine utilization. (311 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa)
AKG04751.1Acetolactate synthase small subunit. (173 aa)
AKG04752.1Acetolactate synthase, large subunit, biosynthetic type. (576 aa)
ilvEBranched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (301 aa)
AKG05742.1Branched chain amino acid aminotransferase. (343 aa)
AKG04926.1Pyruvate oxidase; Catalyzes the formation of acetyl phosphate from pyruvate; Belongs to the TPP enzyme family. (571 aa)
AKG05059.1Glyoxal reductase. (274 aa)
AKG05161.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
AKG05255.12-hydroxy-acid oxidase. (465 aa)
Your Current Organism:
Salimicrobium jeotgali
NCBI taxonomy Id: 1230341
Other names: JCM 19758, KACC 16972, S. jeotgali, Salimicrobium jeotgali Choi et al. 2014, Salimicrobium sp. MJ3, strain MJ3
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