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| | tfb-2 | Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (316 aa) |
| | rad25 | Type III restriction protein res subunit; COG1061 DNA or RNA helicases of superfamily II. (642 aa) |
| | C495_01040 | COG0423 Glycyl-tRNA synthetase (class II). (258 aa) |
| | C495_01155 | Hypothetical protein. (300 aa) |
| | rpl3p | 50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (339 aa) |
| | rpl4lp | 50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (250 aa) |
| | rpl23 | 50S ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (84 aa) |
| | rpl2p | 50S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (240 aa) |
| | rps19p | 30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (140 aa) |
| | rpl22p | 50S ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (161 aa) |
| | rps3p | 30S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (313 aa) |
| | rpl29 | COG0255 Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (70 aa) |
| | rps17p | 30S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (144 aa) |
| | rpl14p | 50S ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa) |
| | rpl24p | 50S ribosomal protein L24P; Located at the polypeptide exit tunnel on the outside of the subunit. (118 aa) |
| | rps4e | COG1471 Ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (233 aa) |
| | rpl5p | 50S ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (178 aa) |
| | rps14P | 30S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (62 aa) |
| | rps8p | 30S ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6p | 50S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa) |
| | rpl32e | 50S ribosomal protein L32e; COG0468 RecA/RadA recombinase; Belongs to the eukaryotic ribosomal protein eL32 family. (241 aa) |
| | rpl19e | 50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (149 aa) |
| | rpl18p | 50S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (182 aa) |
| | rps5p | 30S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (217 aa) |
| | rpl30p | COG1841 Ribosomal protein L30/L7E. (155 aa) |
| | rpl15p | 50S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (166 aa) |
| | secY | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (485 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (211 aa) |
| | cmk | COG1102 Cytidylate kinase. (191 aa) |
| | truB | H/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (306 aa) |
| | tfb-3 | Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (310 aa) |
| | rps13p | 30S ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (173 aa) |
| | rps4p | 30S ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (173 aa) |
| | rps11p | 30S ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (249 aa) |
| | rpl18e | COG1727 Ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (117 aa) |
| | rpl13p | 50S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (149 aa) |
| | rps9p | COG0103 Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (132 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (64 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (59 aa) |
| | rps2P | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (265 aa) |
| | tmcA | Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (758 aa) |
| | rpl7ae | 50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (120 aa) |
| | rps28e | COG2053 Ribosomal protein S28E/S33; Belongs to the eukaryotic ribosomal protein eS28 family. (74 aa) |
| | rpl24e | 50S ribosomal protein L24E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL24 family. (106 aa) |
| | ndk | Mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (154 aa) |
| | rps8e | COG2007 Ribosomal protein S8E. (123 aa) |
| | ksgA | 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (280 aa) |
| | C495_02640 | DNA-directed RNA polymerase subunit F; COG1460 Uncharacterized protein conserved in archaea. (118 aa) |
| | rpl21e | COG2139 Ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (102 aa) |
| | ef1B | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa) |
| | C495_02680 | COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation. (59 aa) |
| | secE | Preprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (57 aa) |
| | C495_02855 | COG1813 Predicted transcription factor, homolog of eukaryotic MBF1. (174 aa) |
| | C495_02865 | COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (105 aa) |
| | tyrS | tyrosyl-tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (326 aa) |
| | rpl37e | 50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (58 aa) |
| | C495_03237 | Like-Sm ribonucleoprotein core; COG1958 Small nuclear ribonucleoprotein (snRNP) homolog. (75 aa) |
| | pelA | Translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (355 aa) |
| | eif2b | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (203 aa) |
| | eif1a | S1 IF1 family protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (83 aa) |
| | C495_04102 | COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain. (303 aa) |
| | rpl15e | COG1632 Ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (196 aa) |
| | C495_04412 | Thermosome; COG0459 Chaperonin GroEL (HSP60 family); Belongs to the TCP-1 chaperonin family. (553 aa) |
| | rtcA | RNA 3'-terminal-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (368 aa) |
| | rps27ae | COG1998 Ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (44 aa) |
| | rps24e | COG2004 Ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (103 aa) |
| | rps10p | 30S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | tuf | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (420 aa) |
| | proS | prolyl-tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (493 aa) |
| | prf1 | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (419 aa) |
| | argS | COG0018 Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (595 aa) |
| | rpl40e | COG1552 Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (298 aa) |
| | C495_05412 | COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family. (172 aa) |
| | serS | seryl-tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (458 aa) |
| | fusA | Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (728 aa) |
| | rps7 | 30S ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (202 aa) |
| | rps12P | 30S ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa) |
| | nusA | Transcription elongation factor NusA-like protein; Participates in transcription termination. Belongs to the NusA family. (147 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (399 aa) |
| | C495_05943 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (973 aa) |
| | C495_05948 | DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (609 aa) |
| | C495_05953 | COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit; Belongs to the RNA polymerase beta chain family. (526 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (75 aa) |
| | C495_05983 | Zinc finger protein; COG1326 Uncharacterized archaeal Zn-finger protein. (219 aa) |
| | rpl10e | COG0197 Ribosomal protein L16/L10E; Belongs to the universal ribosomal protein uL16 family. (176 aa) |
| | tfb | COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB. (108 aa) |
| | C495_06218 | COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB. (296 aa) |
| | C495_06288 | DEAD/DEAH box helicase; COG1199 Rad3-related DNA helicases. (723 aa) |
| | srp54 | Signal recognition particle protein Srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (460 aa) |
| | ftsY | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (436 aa) |
| | pfdA | Prefoldin subunit alpha; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. (148 aa) |
| | rplX | COG2157 Ribosomal protein L20A (L18A). (57 aa) |
| | eif6 | Translation initiation factor IF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (221 aa) |
| | rpl31e | COG2097 Ribosomal protein L31E; Belongs to the ribosomal protein L31e family. (92 aa) |
| | rpl39e | COG2167 Ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (50 aa) |
| | C495_06578 | NMD3 family protein; COG1499 NMD protein affecting ribosome stability and mRNA decay. (379 aa) |
| | taw2 | Hypothetical protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (385 aa) |
| | C495_06588 | Helicase c2; COG1199 Rad3-related DNA helicases. (606 aa) |
| | rrmJ | 23S rRNA methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (261 aa) |
| | tbp | Transcription factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (186 aa) |
| | C495_06868 | RNA methylase; COG1041 Predicted DNA modification methylase. (371 aa) |
| | pheS | COG0016 Phenylalanyl-tRNA synthetase alpha subunit. (526 aa) |
| | pheT | COG0072 Phenylalanyl-tRNA synthetase beta subunit. (588 aa) |
| | C495_06958 | COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; Belongs to the SUI1 family. (98 aa) |
| | C495_07008 | RIO-like kinase; COG1718 Serine/threonine protein kinase involved in cell cycle control. (291 aa) |
| | C495_07018 | COG1094 Predicted RNA-binding protein (contains KH domains). (185 aa) |
| | leuS | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (877 aa) |
| | hel308 | Ski2-like helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (784 aa) |
| | C495_07425 | Helicase c2; COG1199 Rad3-related DNA helicases. (755 aa) |
| | alaS | alanyl-tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (925 aa) |
| | eif1a-2 | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (96 aa) |
| | ileS | isoleucyl-tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1070 aa) |
| | trpS | tryptophanyl-tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). (526 aa) |
| | C495_08355 | DEAD/DEAH box helicase domain-containing protein; COG1204 Superfamily II helicase. (787 aa) |
| | C495_08450 | COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; Belongs to the SUI1 family. (97 aa) |
| | engB | GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation. (205 aa) |
| | C495_08560 | GTP-binding protein HSR1-like protein; COG1084 Predicted GTPase. (331 aa) |
| | C495_08715 | ATPase RIL; COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog. (604 aa) |
| | hisS | COG0124 Histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (432 aa) |
| | C495_08810 | Hypothetical protein; COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain. (198 aa) |
| | C495_08815 | COG2118 DNA-binding protein; Belongs to the PDCD5 family. (116 aa) |
| | rps19e | 30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (151 aa) |
| | rps6e | COG2125 Ribosomal protein S6E (S10); Belongs to the eukaryotic ribosomal protein eS6 family. (133 aa) |
| | eif2g | Translation initiation factor IF-2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa) |
| | C495_09010 | COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily. (130 aa) |
| | C495_09015 | COG1095 DNA-directed RNA polymerase, subunit E'. (189 aa) |
| | valS | valyl-tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (884 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (468 aa) |
| | eif5a | Translation initiation factor IF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (124 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (599 aa) |
| | C495_10384 | COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module. (152 aa) |
| | metG | methionyl-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (700 aa) |
| | C495_10774 | COG0459 Chaperonin GroEL (HSP60 family); Belongs to the TCP-1 chaperonin family. (514 aa) |
| | nop10 | H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (59 aa) |
| | C495_10794 | COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha). (266 aa) |
| | rps27e | COG2051 Ribosomal protein S27E. (57 aa) |
| | rpl44e | 50S ribosomal protein L44e; Binds to the 23S rRNA. (93 aa) |
| | tfe | Transcription factor TFIIE subunit alpha; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation [...] (174 aa) |
| | leuS-2 | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (919 aa) |
| | C495_12834 | Transcription termination factor Tfs; COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (102 aa) |
| | rps10 | 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (111 aa) |
| | C495_13014 | Hypothetical protein. (167 aa) |
| | rps3ae | COG1890 Ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (213 aa) |
| | rps15p | COG0184 Ribosomal protein S15P/S13E. (155 aa) |
| | pfdB | Prefoldin subunit beta; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. (131 aa) |
| | rpoP | DNA-directed RNA polymerase subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (44 aa) |
| | rpl37ae | 50S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. (86 aa) |
| | truD | tRNA pseudouridine synthase D; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (449 aa) |
| | rpl11p | 50S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (160 aa) |
| | rpl1P | 50S ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (210 aa) |
| | rplP0 | Acidic ribosomal protein P0; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (346 aa) |
| | rpl12p | 50S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (112 aa) |
| | tfb-7 | Transcription initiation factor TFB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (334 aa) |
| | C495_14342 | Hypothetical protein. (506 aa) |
| | C495_14367 | Type III restriction protein res subunit; COG1061 DNA or RNA helicases of superfamily II. (490 aa) |
| | grpE | GrpE protein HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of [...] (303 aa) |
| | dnaK | Molecular chaperone DnaK; Acts as a chaperone. (637 aa) |
| | dnaJ | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (387 aa) |
| | C495_14632 | Hypothetical protein. (279 aa) |
| | cmk-2 | COG1102 Cytidylate kinase. (202 aa) |
| | rps17E | COG1383 Ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (63 aa) |
| | srp19 | Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (93 aa) |
| | C495_15177 | H/ACA RNA-protein complex component Gar1; COG3277 RNA-binding protein involved in rRNA processing. (84 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (94 aa) |
| | C495_15637 | RNA-associated protein; COG1500 Predicted exosome subunit. (241 aa) |
| | C495_15723 | Pre-mRNA processing ribonucleoprotein, binding domain-containing protein; COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog. (202 aa) |
| | flpA | Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (213 aa) |
| | C495_15778 | Heat shock protein DnaJ domain protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. (401 aa) |
| | C495_15788 | Transcription termination factor Tfs; COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (109 aa) |
| | C495_15833 | COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily. (165 aa) |
| | C495_16273 | Protein synthesis factor GTP-binding protein; COG5258 GTPase. (551 aa) |
| | C495_16320 | Type III restriction protein res subunit; COG1061 DNA or RNA helicases of superfamily II. (289 aa) |
| | C495_16840 | Hypothetical protein. (443 aa) |
| | C495_16845 | COG1061 DNA or RNA helicases of superfamily II. (78 aa) |
| | C495_16990 | Hypothetical protein; COG0459 Chaperonin GroEL (HSP60 family); Belongs to the chaperonin (HSP60) family. (590 aa) |
