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hisF hisF C495_02790 C495_02790 hisH hisH hisG hisG hisI hisI hisA hisA hisB hisB hisE hisE C495_08915 C495_08915 C495_12545 C495_12545 C495_12704 C495_12704 hisC hisC hisD hisD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Your Input:
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa)
C495_02790COG1796 DNA polymerase IV (family X). (583 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (288 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (123 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (245 aa)
hisBCOG0131 Imidazoleglycerol-phosphate dehydratase. (195 aa)
hisECOG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (94 aa)
C495_08915COG1387 Histidinol phosphatase and related hydrolases of the PHP family. (260 aa)
C495_12545COG1012 NAD-dependent aldehyde dehydrogenases. (511 aa)
C495_12704Amine oxidase; COG1233 Phytoene dehydrogenase and related proteins. (430 aa)
hisCCOG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (379 aa)
hisDBifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
Your Current Organism:
Natronorubrum sulfidifaciens
NCBI taxonomy Id: 1230460
Other names: N. sulfidifaciens JCM 14089, Natronorubrum sp. AD2, Natronorubrum sulfidifaciens AD2, Natronorubrum sulfidifaciens JCM 14089
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