STRINGSTRING
C495_00595 C495_00595 C495_00895 C495_00895 C495_01055 C495_01055 C495_01790 C495_01790 priS priS C495_03272 C495_03272 C495_03822 C495_03822 C495_05497 C495_05497 C495_05663 C495_05663 C495_06193 C495_06193 C495_06213 C495_06213 pcn pcn priL priL ligA ligA polC polC polB polB rfc rfc dnaG dnaG rnhB rnhB C495_11659 C495_11659 fen fen C495_13466 C495_13466 C495_13656 C495_13656 rfcL rfcL lig lig C495_16345 C495_16345 C495_16495 C495_16495 C495_17212 C495_17212
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C495_00595Cobyrinic acid ac-diamide synthase; COG1192 ATPases involved in chromosome partitioning. (333 aa)
C495_00895Replication factor A; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (424 aa)
C495_01055Spo0A activation inhibitor; COG1192 ATPases involved in chromosome partitioning. (112 aa)
C495_01790COG0328 Ribonuclease HI. (197 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (391 aa)
C495_03272DNA replication factor Dna2; COG1112 Superfamily I DNA and RNA helicases and helicase subunits. (939 aa)
C495_03822DNA-directed DNA polymerase type II; COG0417 DNA polymerase elongation subunit (family B). (818 aa)
C495_05497Replication factor A; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (477 aa)
C495_05663OB-fold tRNA/helicase-type nucleic acid binding-protein; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (309 aa)
C495_06193Hypothetical protein; COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family. (1260 aa)
C495_06213Cell division control protein 21; COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family; Belongs to the MCM family. (1172 aa)
pcnDNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (359 aa)
ligANAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (694 aa)
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1719 aa)
polBDNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (518 aa)
rfcReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (329 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (468 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (219 aa)
C495_11659COG1403 Restriction endonuclease. (264 aa)
fenFlap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (325 aa)
C495_13466COG0417 DNA polymerase elongation subunit (family B). (1321 aa)
C495_13656COG3620 Predicted transcriptional regulator with C-terminal CBS domains. (179 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (494 aa)
ligATP-dependent DNA ligase I; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (563 aa)
C495_16345COG1192 ATPases involved in chromosome partitioning. (283 aa)
C495_16495OB-fold tRNA/helicase-type nucleic acid binding-protein; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (282 aa)
C495_17212Cobyrinic acid ac-diamide synthase; COG1192 ATPases involved in chromosome partitioning. (295 aa)
Your Current Organism:
Natronorubrum sulfidifaciens
NCBI taxonomy Id: 1230460
Other names: N. sulfidifaciens JCM 14089, Natronorubrum sp. AD2, Natronorubrum sulfidifaciens AD2, Natronorubrum sulfidifaciens JCM 14089
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