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| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | C802_00015 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa) |
| | C802_00050 | Hypothetical protein. (244 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (396 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (493 aa) |
| | C802_00140 | Histidine ammonia-lyase. (507 aa) |
| | C802_00142 | 3-oxoacyl-[acyl-carrier protein] reductase. (242 aa) |
| | C802_00143 | 3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (409 aa) |
| | C802_00144 | Acyl carrier protein. (83 aa) |
| | C802_00147 | Hypothetical protein. (145 aa) |
| | C802_00149 | Hypothetical protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (576 aa) |
| | C802_00150 | Acyl carrier protein. (85 aa) |
| | C802_00151 | 3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (396 aa) |
| | C802_00152 | Hypothetical protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (317 aa) |
| | C802_00157 | 3R-hydroxymyristoyl ACP dehydrase. (125 aa) |
| | pfkA | 6-phosphofructokinase 3; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (336 aa) |
| | fabF | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (421 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | C802_00207 | Histidinol-phosphate transaminase. (349 aa) |
| | argS | arginyl-tRNA synthetase. (606 aa) |
| | C802_00219 | Serine O-acetyltransferase. (302 aa) |
| | C802_00242 | Hypothetical protein. (138 aa) |
| | C802_00324 | Gluconate 5-dehydrogenase. (267 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (330 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (944 aa) |
| | C802_00438 | Succinate CoA transferase. (497 aa) |
| | C802_00448 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. (148 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (430 aa) |
| | C802_00498 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (150 aa) |
| | C802_03256 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. (124 aa) |
| | dapB | Dihydrodipicolinate reductase; Belongs to the DapB family. (251 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (391 aa) |
| | C802_00616 | Hypothetical protein. (585 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (630 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa) |
| | C802_00674 | SufS family cysteine desulfurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (404 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (504 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (614 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | C802_00766 | Hypothetical protein. (87 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (503 aa) |
| | C802_00776 | Hypothetical protein. (171 aa) |
| | C802_00777 | Hypothetical protein. (510 aa) |
| | C802_00851 | O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase. (425 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (158 aa) |
| | C802_00943 | Hypothetical protein. (185 aa) |
| | C802_00944 | Argininosuccinate synthase. (402 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (322 aa) |
| | C802_00946 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (374 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa) |
| | C802_00962 | acetyl-CoA synthetase. (550 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | C802_00978 | N-acetylornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (321 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (219 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | C802_01072 | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (333 aa) |
| | fabZ | Bifunctional enzyme lpxC/fabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1234 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (416 aa) |
| | asnA | Aspartate-ammonia ligase. (346 aa) |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (263 aa) |
| | C802_01281 | N-acetylneuraminate lyase; Belongs to the DapA family. (304 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (447 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (576 aa) |
| | C802_01322 | L-asparaginase, type I. (347 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | C802_01325 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (331 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | C802_01351 | Hypothetical protein. (143 aa) |
| | C802_01353 | Hypothetical protein. (517 aa) |
| | mce | methylmalonyl-CoA epimerase. (137 aa) |
| | C802_01394 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (917 aa) |
| | C802_01398 | Hypothetical protein. (450 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa) |
| | C802_01403 | Shikimate 5-dehydrogenase. (246 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (600 aa) |
| | ilvB | Acetolactate synthase, large subunit, biosynthetic type. (565 aa) |
| | ilvN | Acetolactate synthase, small subunit. (184 aa) |
| | C802_01417 | Hypothetical protein. (246 aa) |
| | ilvC | Ketol-acid reductoisomerase. (347 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (875 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (346 aa) |
| | hisB | Histidine biosynthesis hisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (372 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (319 aa) |
| | bioA | Biotin synthase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (423 aa) |
| | bioC | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (214 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (409 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa) |
| | C802_01634 | Dihydrodipicolinate synthase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (310 aa) |
| | ansB | L-asparaginase, type II; Belongs to the asparaginase 1 family. (352 aa) |
| | C802_01641 | 6-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (478 aa) |
| | C802_01657 | Iron-sulfur cluster-binding protein. (455 aa) |
| | C802_01658 | Hypothetical protein. (195 aa) |
| | C802_01671 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (397 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | C802_01703 | Hypothetical protein. (232 aa) |
| | C802_01711 | Hypothetical protein. (263 aa) |
| | C802_01727 | Hypothetical protein. (220 aa) |
| | C802_01829 | GMP synthase (glutamine-hydrolyzing) domain-containing protein. (435 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase A; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | C802_01854 | Hypothetical protein. (176 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (646 aa) |
| | C802_01897 | O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase. (428 aa) |
| | C802_01917 | KamA family protein. (703 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa) |
| | C802_01974 | Asparagine synthase (glutamine-hydrolyzing). (555 aa) |
| | C802_01975 | Glutamate synthase, NADH/NADPH, small subunit. (470 aa) |
| | C802_01976 | Glutamate synthase (NADPH/NADH) large chain. (1492 aa) |
| | glmS | Glucosamine-fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (614 aa) |
| | C802_01979 | Amidophosphoribosyltransferase. (627 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (358 aa) |
| | C802_01983 | Hypothetical protein. (153 aa) |
| | C802_01987 | Malonyl CoA-acyl carrier protein transacylase. (334 aa) |
| | C802_02033 | glutamine-tRNA ligase. (579 aa) |
| | C802_02050 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. (456 aa) |
| | C802_02074 | C_GCAxxG_C_C family protein. (186 aa) |
| | glsA | Glutaminase; Belongs to the glutaminase family. (320 aa) |
| | C802_02085 | Glutamate decarboxylase; Belongs to the group II decarboxylase family. (482 aa) |
| | C802_02086 | Threonine dehydratase. (108 aa) |
| | C802_02141 | Proline dehydrogenase/delta 1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (1144 aa) |
| | C802_02168 | Glycine dehydrogenase [decarboxylating]; Belongs to the GcvP family. (949 aa) |
| | C802_02169 | Hypothetical protein. (203 aa) |
| | C802_02177 | Hypothetical protein. (554 aa) |
| | uxuA-2 | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (392 aa) |
| | C802_02206 | Altronate hydrolase. (496 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1162 aa) |
| | C802_02225 | Hypothetical protein. (267 aa) |
| | uxaC | Uronate isomerase. (468 aa) |
| | C802_02232 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (317 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (442 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (496 aa) |
| | C802_02254 | Nucleotide sugar dehydrogenase. (449 aa) |
| | C802_02260 | Phosphoserine phosphatase SerB. (410 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (587 aa) |
| | C802_02300 | Acyl carrier protein. (74 aa) |
| | C802_02302 | 3-oxoacyl-[acyl-carrier protein] reductase. (240 aa) |
| | C802_02332 | Hypothetical protein. (172 aa) |
| | C802_02374 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | C802_02398 | O-succinylbenzoate synthase. (351 aa) |
| | pfp | Diphosphate-fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (547 aa) |
| | C802_02562 | Hypothetical protein. (295 aa) |
| | C802_02582 | PhnP protein. (258 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (344 aa) |
| | C802_02588 | 4-amino-4-deoxychorismate lyase. (197 aa) |
| | folD | FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (122 aa) |
| | C802_02627 | Long-chain acyl-CoA synthetase. (569 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (498 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (460 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa) |
| | C802_02674 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (511 aa) |
| | C802_02675 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (353 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | C802_02702 | Hypothetical protein. (339 aa) |
| | glyQS | glycine-tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (513 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | C802_02743 | methylmalonyl-CoA mutase, small subunit. (636 aa) |
| | C802_02759 | Radical SAM additional 4Fe4S-binding SPASM domain-containing protein. (502 aa) |
| | C802_02771 | Radical SAM additional 4Fe4S-binding SPASM domain-containing protein. (492 aa) |
| | C802_02787 | Branched-chain amino acid aminotransferase. (339 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa) |
| | C802_02803 | NAD-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | C802_02804 | Hypothetical protein. (985 aa) |
| | pfkA-2 | 6-phosphofructokinase 2; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (326 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (288 aa) |
| | C802_02846 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa) |
| | C802_02856 | Isocitrate dehydrogenase, NADP-dependent. (381 aa) |
| | C802_02893 | Enoyl-[acyl-carrier protein] reductase I. (285 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (284 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (680 aa) |
| | C802_02947 | Radical SAM enzyme, rSAM/lipoprotein system protein. (358 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (140 aa) |
| | C802_02999 | Pyruvate kinase; Belongs to the pyruvate kinase family. (487 aa) |
| | argH | Argininosuccinate lyase. (446 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (505 aa) |
| | C802_03058 | Acetylornithine deacetylase. (354 aa) |
| | C802_03059 | Long-chain acyl-CoA synthetase. (601 aa) |
| | C802_03076 | Hypothetical protein. (356 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (356 aa) |
| | C802_03171 | Arginase; Belongs to the arginase family. (348 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (496 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa) |
| | C802_03280 | Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (924 aa) |
| | C802_03281 | Hypothetical protein. (618 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (275 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (820 aa) |
| | C802_03323 | Radical SAM additional 4Fe4S-binding SPASM domain-containing protein. (357 aa) |
| | C802_03339 | Hypothetical protein. (290 aa) |
| | C802_03345 | Glutamine synthetase. (500 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (317 aa) |
| | C802_03499 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (821 aa) |
| | C802_03536 | Threonine aldolase. (338 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (239 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisI | Histidine biosynthesis HisIE; In the N-terminal section; belongs to the PRA-CH family. (203 aa) |
| | C802_03551 | Aspartate kinase; Belongs to the aspartokinase family. (439 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (386 aa) |
| | C802_03565 | Long-chain acyl-CoA synthetase. (552 aa) |
| | C802_03586 | Hypothetical protein. (348 aa) |
| | C802_03607 | Hypothetical protein. (291 aa) |
| | C802_03609 | Hypothetical protein. (154 aa) |
| | C802_03617 | Hypothetical protein. (403 aa) |
| | ald | Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (363 aa) |
| | serS | serine-tRNA ligase. (424 aa) |
| | C802_03650 | Glutamate synthase (NADPH), homotetrameric. (765 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (361 aa) |
| | C802_03729 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (468 aa) |
| | C802_03774 | Hypothetical protein; Belongs to the membrane-bound acyltransferase family. (493 aa) |
| | C802_03786 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (761 aa) |
| | C802_03787 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (871 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (353 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa) |
| | C802_03823 | Fructose-bisphosphate aldolase, class I. (350 aa) |
| | C802_03824 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (409 aa) |
| | C802_03851 | Hypothetical protein. (92 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | C802_03977 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (316 aa) |
| | trpS | tryptophan-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (364 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (334 aa) |
| | hisS | histidyl-tRNA synthetase. (454 aa) |
| | C802_04074 | [FeFe] hydrogenase H-cluster radical SAM maturase HydE. (344 aa) |
| | hutH | Histidine ammonia-lyase. (498 aa) |
| | hutI | Imidazolonepropionase. (414 aa) |
| | C802_04092 | Glutamate formiminotransferase. (294 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (665 aa) |
| | C802_04104 | Hypothetical protein. (202 aa) |
| | C802_04145 | Hypothetical protein. (176 aa) |
| | C802_04193 | Hypothetical protein; Belongs to the membrane-bound acyltransferase family. (463 aa) |
| | C802_04194 | Acyl carrier protein. (80 aa) |
| | C802_04265 | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (436 aa) |
| | C802_04266 | 2-oxoisovalerate dehydrogenase E1 component. (677 aa) |
| | thrA | Aspartate kinase. (810 aa) |
| | C802_04275 | Putative homoserine kinase. (403 aa) |
| | C802_04276 | Threonine synthase. (433 aa) |
| | C802_04299 | Hypothetical protein. (257 aa) |
| | C802_04300 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (355 aa) |
| | C802_04301 | Hypothetical protein. (394 aa) |
| | C802_04302 | Prephenate dehydratase. (280 aa) |
| | C802_04333 | Hypothetical protein; Belongs to the UPF0597 family. (431 aa) |
| | C802_04354 | Hypothetical protein. (219 aa) |
| | C802_04370 | Fructose-1,6-bisphosphate aldolase, class II. (366 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (382 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa) |
| | C802_04407 | Hypothetical protein. (205 aa) |
| | asnS | asparaginyl-tRNA synthetase. (467 aa) |
