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glyA glyA argH argH C802_02846 C802_02846 C802_02787 C802_02787 asd asd metAA metAA C802_02675 C802_02675 C802_02674 C802_02674 leuD leuD leuC leuC leuA leuA folD folD C802_02562 C802_02562 C802_02374 C802_02374 C802_02332 C802_02332 C802_02260 C802_02260 C802_02086 C802_02086 C802_02074 C802_02074 carA carA C802_01976 C802_01976 C802_01975 C802_01975 C802_01974 C802_01974 C802_01854 C802_01854 C802_01727 C802_01727 C802_01703 C802_01703 panD panD C802_01634 C802_01634 dapF dapF dapL dapL ilvC ilvC ilvN ilvN ilvB ilvB ilvD ilvD C802_01398 C802_01398 C802_01394 C802_01394 trpB trpB trpD trpD C802_01325 C802_01325 trpF trpF trpA trpA C802_01281 C802_01281 asnA asnA C802_00978 C802_00978 proA proA proB proB proC proC C802_00946 C802_00946 argC argC C802_00944 C802_00944 C802_00943 C802_00943 argR argR argB argB dapB dapB C802_00242 C802_00242 C802_00219 C802_00219 C802_00015 C802_00015 dapA dapA serC serC C802_03058 C802_03058 C802_04302 C802_04302 C802_04301 C802_04301 C802_04299 C802_04299 C802_04276 C802_04276 thrA thrA C802_03977 C802_03977 C802_03650 C802_03650 lysA lysA C802_03551 C802_03551 C802_03499 C802_03499 C802_03345 C802_03345
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
argHArgininosuccinate lyase. (446 aa)
C802_02846Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa)
C802_02787Branched-chain amino acid aminotransferase. (339 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa)
C802_026753-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (353 aa)
C802_02674D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (511 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (460 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (498 aa)
folDFolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa)
C802_02562Hypothetical protein. (295 aa)
C802_02374Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa)
C802_02332Hypothetical protein. (172 aa)
C802_02260Phosphoserine phosphatase SerB. (410 aa)
C802_02086Threonine dehydratase. (108 aa)
C802_02074C_GCAxxG_C_C family protein. (186 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (358 aa)
C802_01976Glutamate synthase (NADPH/NADH) large chain. (1492 aa)
C802_01975Glutamate synthase, NADH/NADPH, small subunit. (470 aa)
C802_01974Asparagine synthase (glutamine-hydrolyzing). (555 aa)
C802_01854Hypothetical protein. (176 aa)
C802_01727Hypothetical protein. (220 aa)
C802_01703Hypothetical protein. (232 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa)
C802_01634Dihydrodipicolinate synthase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (310 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa)
dapLLL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (409 aa)
ilvCKetol-acid reductoisomerase. (347 aa)
ilvNAcetolactate synthase, small subunit. (184 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type. (565 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (600 aa)
C802_01398Hypothetical protein. (450 aa)
C802_01394Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (917 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (331 aa)
C802_01325Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (205 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa)
C802_01281N-acetylneuraminate lyase; Belongs to the DapA family. (304 aa)
asnAAspartate-ammonia ligase. (346 aa)
C802_00978N-acetylornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (321 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa)
C802_00946Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (374 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (322 aa)
C802_00944Argininosuccinate synthase. (402 aa)
C802_00943Hypothetical protein. (185 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (158 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa)
dapBDihydrodipicolinate reductase; Belongs to the DapB family. (251 aa)
C802_00242Hypothetical protein. (138 aa)
C802_00219Serine O-acetyltransferase. (302 aa)
C802_00015MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (356 aa)
C802_03058Acetylornithine deacetylase. (354 aa)
C802_04302Prephenate dehydratase. (280 aa)
C802_04301Hypothetical protein. (394 aa)
C802_04299Hypothetical protein. (257 aa)
C802_04276Threonine synthase. (433 aa)
thrAAspartate kinase. (810 aa)
C802_03977Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (316 aa)
C802_03650Glutamate synthase (NADPH), homotetrameric. (765 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (386 aa)
C802_03551Aspartate kinase; Belongs to the aspartokinase family. (439 aa)
C802_03499Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (821 aa)
C802_03345Glutamine synthetase. (500 aa)
Your Current Organism:
Bacteroides sartorii
NCBI taxonomy Id: 1235788
Other names: B. sartorii dnLKV3, Bacteroides sartorii dnLKV3
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