(63 nodes) Citrate cycle (TCA cycle) network (Colletotrichum gloeosporioides)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	CGLO_04005	MFS domain-containing protein. (518 aa)
	CGLO_18075	Uncharacterized protein. (190 aa)
	CGLO_13759	Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (265 aa)
	CGLO_13679	Transketolase. (59 aa)
	CGLO_15592	Major facilitator superfamily transporter. (521 aa)
	CGLO_16606	Uncharacterized protein. (489 aa)
	CGLO_14504	Uncharacterized protein. (778 aa)
	CGLO_14986	Malate dehydrogenase. (330 aa)
	CGLO_12584	Oxoglutarate dehydrogenase. (1042 aa)
	CGLO_17408	Uncharacterized protein. (369 aa)
	CGLO_02628	Glutathione-dependent formaldehyde-activating enzyme. (215 aa)
	CGLO_02494	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (808 aa)
	CGLO_16709	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (184 aa)
	CGLO_01387	Malate dehydrogenase. (333 aa)
	CGLO_00470	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (276 aa)
	CGLO_00556	Uncharacterized protein. (181 aa)
	CGLO_17859	Major facilitator superfamily transporter. (493 aa)
	CGLO_17465	2-oxoacid_dh domain-containing protein. (480 aa)
	CGLO_15305	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (409 aa)
	CGLO_14605	Transketolase. (125 aa)
	CGLO_14368	Major facilitator superfamily transporter. (490 aa)
	CGLO_16768	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (792 aa)
	CGLO_16801	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (1028 aa)
	CGLO_17618	Major facilitator superfamily transporter. (706 aa)
	CGLO_10519	Iso_dh domain-containing protein. (365 aa)
	CGLO_10186	Major facilitator superfamily transporter. (484 aa)
	CGLO_13647	Major facilitator superfamily transporter. (416 aa)
	CGLO_12470	Uncharacterized protein. (135 aa)
	CGLO_08182	Major facilitator superfamily transporter. (627 aa)
	CGLO_10746	Phosphoenolpyruvate carboxykinase. (561 aa)
	CGLO_09658	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (445 aa)
	CGLO_09466	MFS domain-containing protein. (272 aa)
	CGLO_10154	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (381 aa)
	CGLO_09158	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1196 aa)
	CGLO_08857	Uncharacterized protein. (448 aa)
	CGLO_05117	Major facilitator superfamily transporter. (528 aa)
	CGLO_07003	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1001 aa)
	CGLO_02506	GFA domain-containing protein. (137 aa)
	CGLO_05074	Ligase_CoA domain-containing protein. (554 aa)
	CGLO_12697	Citrate synthase; Belongs to the citrate synthase family. (463 aa)
	CGLO_06539	AARP2CN domain-containing protein. (814 aa)
	CGLO_10518	Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
	CGLO_06754	Major facilitator superfamily transporter. (485 aa)
	CGLO_07465	Citrate synthase; Belongs to the citrate synthase family. (528 aa)
	CGLO_07986	Major facilitator superfamily transporter. (599 aa)
	CGLO_04465	Lipoyl-binding domain-containing protein. (462 aa)
	CGLO_00469	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (644 aa)
	CGLO_00246	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (337 aa)
	CGLO_18084	Glutathione-dependent formaldehyde-activating enzyme. (122 aa)
	CGLO_17810	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (791 aa)
	CGLO_16951	Dihydrolipoyl dehydrogenase. (477 aa)
	CGLO_06182	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (453 aa)
	CGLO_05939	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (447 aa)
	CGLO_03814	MFS domain-containing protein. (493 aa)
	CGLO_03108	Major facilitator superfamily transporter. (633 aa)
	CGLO_06413	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (349 aa)
	CGLO_06036	Citrate synthase; Belongs to the citrate synthase family. (509 aa)
	CGLO_05938	Uncharacterized protein. (401 aa)
	CGLO_02528	Uncharacterized protein. (370 aa)
	CGLO_05205	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (377 aa)
	CGLO_04466	Oxoglutarate dehydrogenase. (1038 aa)
	CGLO_03040	Major facilitator superfamily transporter. (508 aa)
	CGLO_01996	Fumarate hydratase. (470 aa)

Your Current Organism:

Colletotrichum gloeosporioides

NCBI taxonomy Id: 1237896
Other names: C. gloeosporioides Cg-14, Colletotrichum gloeosporioides Cg-14

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGLO_00246	CGLO_00469	T0KV07	T0KUH0	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.953
CGLO_00246	CGLO_00470	T0KV07	T0L329	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.985
CGLO_00246	CGLO_00556	T0KV07	T0L3R2	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Uncharacterized protein.	0.976
CGLO_00246	CGLO_01387	T0KV07	T0L1M9	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Malate dehydrogenase.	0.883
CGLO_00246	CGLO_01996	T0KV07	T0M9Z8	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Fumarate hydratase.	0.941
CGLO_00246	CGLO_02494	T0KV07	T0KYN1	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.759
CGLO_00246	CGLO_02506	T0KV07	T0KNP7	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	GFA domain-containing protein.	0.464
CGLO_00246	CGLO_02528	T0KV07	T0M0R8	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Uncharacterized protein.	0.883
CGLO_00246	CGLO_02628	T0KV07	T0KYF6	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Glutathione-dependent formaldehyde-activating enzyme.	0.464
CGLO_00246	CGLO_04465	T0KV07	T0KU27	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Lipoyl-binding domain-containing protein.	0.961
CGLO_00246	CGLO_04466	T0KV07	T0M4A1	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Oxoglutarate dehydrogenase.	0.963
CGLO_00246	CGLO_05074	T0KV07	T0KQW4	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Ligase_CoA domain-containing protein.	0.967
CGLO_00246	CGLO_05205	T0KV07	T0M2F5	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.690
CGLO_00246	CGLO_05938	T0KV07	T0M0A0	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Uncharacterized protein.	0.691
CGLO_00246	CGLO_05939	T0KV07	T0LRC9	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.691
CGLO_00246	CGLO_06036	T0KV07	T0M026	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Citrate synthase; Belongs to the citrate synthase family.	0.860
CGLO_00246	CGLO_06182	T0KV07	T0LQS7	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.959
CGLO_00246	CGLO_06413	T0KV07	T0LZ86	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.782
CGLO_00246	CGLO_07465	T0KV07	T0LMC8	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Citrate synthase; Belongs to the citrate synthase family.	0.860
CGLO_00246	CGLO_08857	T0KV07	T0KF45	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Uncharacterized protein.	0.998