STRINGSTRING
nfuA nfuA yadR yadR grxD grxD sufE sufE KSB65676.1 KSB65676.1 sufC sufC sufB sufB sufA sufA KSB64568.1 KSB64568.1 KSB61297.1 KSB61297.1 KSB59880.1 KSB59880.1 cyaY cyaY KSB59201.1 KSB59201.1 KSB58938.1 KSB58938.1 hscA hscA hscB hscB iscA iscA nifU nifU iscS iscS KSB58770.1 KSB58770.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nfuAFe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa)
yadRIron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa)
grxDGlutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa)
sufECysteine desufuration protein SufE; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa)
KSB65676.1With SufBC activates cysteine desulfurase SufS; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
sufCCysteine desulfurase; Part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
sufBWith SufCD activates cysteine desulfurase SufS; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
sufAFunctions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family. (122 aa)
KSB64568.1Cysteine sulfinate desulfinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
KSB61297.1DNA repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
KSB59880.1ferredoxin-NADP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
cyaYFrataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa)
KSB59201.1Antiporter; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (369 aa)
KSB58938.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
hscAChaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (616 aa)
hscBCo-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa)
iscAIron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. (107 aa)
nifUScaffolding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. (404 aa)
KSB58770.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BolA/IbaG family. (84 aa)
Your Current Organism:
Salmonella enterica salamae
NCBI taxonomy Id: 1243604
Other names: S. enterica subsp. salamae serovar 56:z10:e,n,x str. 1369-73, Salmonella enterica subsp. salamae serovar 56:z10:e,n,x str. 1369-73, Salmonella enterica subsp. salamae serovar 56:z10:enx str. SA20011914
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