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sdhB sdhB bioB bioB KSB67046.1 KSB67046.1 nirD nirD yheA yheA KSB66137.1 KSB66137.1 frdB frdB hcp hcp nsrR nsrR fhuF fhuF yadR yadR grxD grxD sufB sufB sufA sufA nuoE nuoE KSB63726.1 KSB63726.1 yfaE yfaE prpD prpD ilvD ilvD fdx fdx iscA iscA iscS iscS iscR iscR KSB58770.1 KSB58770.1 KSB58950.1 KSB58950.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa)
KSB67046.1HCP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
nirDInvolved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
yheABacterioferritin-associated ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (64 aa)
KSB66137.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
frdBPart of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (550 aa)
nsrRTranscriptional repressor NsrR; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa)
fhuFIron reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
yadRIron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa)
grxDGlutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa)
sufBWith SufCD activates cysteine desulfurase SufS; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
sufAFunctions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family. (122 aa)
nuoENADH dehydrogenase; Catalyzes the transfer of electrons from NADH to quinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
KSB63726.1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (908 aa)
yfaE2Fe-2S ferredoxin; Plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
prpD2-methylcitrate dehydratase; Functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (616 aa)
fdx2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
iscAIron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. (107 aa)
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. (404 aa)
iscRTranscriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (164 aa)
KSB58770.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BolA/IbaG family. (84 aa)
KSB58950.1Sulfite reductase; With AsrAC catalyzes the reduction of sulfite to hydrogen sulfide; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
Your Current Organism:
Salmonella enterica salamae
NCBI taxonomy Id: 1243604
Other names: S. enterica subsp. salamae serovar 56:z10:e,n,x str. 1369-73, Salmonella enterica subsp. salamae serovar 56:z10:e,n,x str. 1369-73, Salmonella enterica subsp. salamae serovar 56:z10:enx str. SA20011914
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